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Effect of Formulation Parameters and Physiological Environment on Amlodipine Release Kinetics Encapsulated in Biodegradable Polymers and Optimized by Design Methodology
In this study, two polyelectrolytes, chitosan and propyl methyl cellulose carbonate, were associated by crosslinking with tripolyphosphate (TPP), to...
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Utilizing Solid-State NMR Spectroscopy to Assess Properties of Lyophilized Formulations
Solid-state nuclear magnetic resonance (NMR) spectroscopy (SSNMR) is a powerful analytical technique that can be utilized to study lyophilized...
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Therapeutic Proteins and Advanced Therapy Medicinal Products
This chapter is divided in two parts: Therapeutic proteins and Advanced Therapy Medicinal Products (ATMPs)....
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Host-Guest Complex of Cucurbituril with 5-Fluorouracil: Structural Study, Effect on Cytotoxicity, and Intracellular ROS Generation
Cucurbiturils are magnificent macrocycles that are used as precise molecules for the fabrication of supramolecular chemotherapeutic agents through...
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Physicochemical and Biopharmaceutical Studies of Solid Dispersions of Cinnarizine
Cinnarizine is an economically affordable drug that belongs to the calcium-channel blocker group and is widely used to treat cerebral diseases. It is...
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Biodegradable Long-Acting Injectables: Platform Technology and Industrial Challenges
Long-acting injectables have been used to benefit patients with chronic diseases. So far, several biodegradable long-acting platform technologies...
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Study of Impurity Profiles in Raw Materials and Tablets of Rutin and Its Production Process: Correlation Analysis
An HPLC-UV method with high sensitivity and good resolution, calculated by the principal component external standard method with correction factors...
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Ternary Solid Dispersion of Celecoxib Produced by the Solvent Method with Improved Solubility and Dissolution Properties
Celecoxib, the first cyclooxygenase-2 selective nonsteroidal anti-inflammatory drug, has a wide range of pharmacological effects, including...
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Application of a Magnetic Molecularly Imprinted Polymer for the Removal of Sulfanilamide as Major Impurity in Eye Drops (Sulfacetamide)
Magnetic molecularly imprinted polymers (MIPs) have been synthesized for the removal of sulfanilamide as a major impurity in the sulfacetamide eye...
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Potential Uses of Polysaccharides from Plant Exudates for Treating Gastrointestinal Diseases
Gum exudates are polysaccharides produced by the trunks and branches of plants as a defense mechanism against harmful agents. The easy extraction and...
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Preparation and In Vitro/Vivo Evaluation of New Celecoxib Solid Dispersions with Co-Carrier Containing Aerosil and Poloxamer 188
Solid dispersions (SDs) containing co-carrier were developed to improve in vitro dissolution and in vivo pharmacokinetics of celecoxib (CXB). Various...
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Recycling Preparative Liquid Chromatography, the Overlooked Methodology for the Purification of Natural Products
Frequently, preparative high-performance liquid chromatography separations of complex natural product mixtures by adsorption chromatography are...
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Challenges and Considerations in the Development of a High Protein Concentration Lyophilized Drug Product
The lyophilized high concentration protein drug products have the advantages of product stability suitable for ADC and other stability sensitive...
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QUALITY REQUIREMENTS FOR HERBAL DRUGS; ANALYTICAL METHODS
In the broadest sense, all plants that are used for healing purposes, based on either traditional use or scientific data, are referred to as...
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Quality of FDM 3D Printed Medicines for Pediatrics: Considerations for Formulation Development, Filament Extrusion, Printing Process and Printer Design
3d printing is capable of providing dose individualization for pediatric medicines and translating the precision medicine approach into practical...
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Advanced Formulation Approaches for Proteins
Proteins and peptides are highly desirable as therapeutic agents, being highly potent and specific. However, there are myriad challenges with...
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Extended-Release Tablets of Nitrofurantoin: An Old Antibiotic Carried in a New Formulation
Nitrofurantoin is an old antibiotic currently prescribed to treat urinary tract infections. High dosing frequency causes fluctuations in the drug...
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Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran
BackgroundIn predictions about hepatic clearance (CL H ), a number of studies explored the role of albumin and transporters in drug uptake by liver...
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Enhancing solubility and bioavailability of coenzyme Q10: formulation of solid dispersions using Soluplus® as a carrier
Improving the aqueous solubility of poorly soluble compounds have been a major issue in the pharmaceutical industry. In the present study, binary...
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Design and optimization various formulations of PEGylated niosomal nanoparticles loaded with phytochemical agents: potential anti-cancer effects against human lung cancer cells
BackgroundPhytochemicals and their derivatives are good options to improve treatment efficiency in cancer patients. Artemisinin (ART) and metformin...
