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Synthesis and Evaluation of New 5,15-Diarylporphyrin Derivatives for Photodynamic Therapy
Two new 5,15-diarylporphyrin derivatives ( L1 and L2 ) were designed and synthesized and their anti-esophageal cancer effects as photosensitizers were...
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Synthesis of Quinoxaline Derivatives as Intermediates to Obtain Erdafitinib
As an important member of multi-nitrogen heterocyclic compounds, quinoxalines have various biological activities which are widely used in chemistry,...
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Synthesis and Neurotropic Activity of Novel Condensed Cyclopentanopyrido[3',2':4,5]-Thieno[3,2-D]Pyrimidine Derivatives
2-Oxo-2,5,6,7-tetrahydro-3-cyano-1 H -cyclopenta[ b ]pyridine was used as the starting point to develop an accessible synthesis of condensed...
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Design, Synthesis and Antifungal Activity of Phloroglucinol Derivatives
Phloroglucinols of Dryopteris fragrans (L.) Schott plant show strong antifungal activity. In previous work, we isolated a wide range of...
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Design and Synthesis of New Series of 2-Oxo-2H-Selenopyrano[2,3-b]Quinoline-3-Carboxylates and Evaluation of Their Antibacterial Activity
In the present work, newly designed ethyl 2-oxo-2 H -selenopyrano[2, 3- b ]quinoline-3-carboxylates (4a–4f) were synthesized by reaction of...
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Synthesis and Analgesic Activity of 4,10-Bis((±)-5-Benzoyl-2,3-Dihydro-1hpyrrolo[1,2-a]Pyrrole-1-Carbonyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazatetracyclo[5,5,03,11,05,9]Dodecane
A method of preparing the potential analgesic substance 4,10-bis((±)-5-benzoyl-2,3-dihydro-1 H -pyrrolo-[1,2- a ]pyrrole-1-carbonyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0...
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Synthesis, Cytotoxic Activity and Molecular Docking Studies of New Condensed Thieno[2,3-d]Pyrimidines as Antitumor Agents
A series of twenty molecules based on thienopyrimidine nucleus fused with 5-, 6-, and 7-membered lactam rings as well as triazole were synthesized...
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Synthesis, Structure Elucidation and Antimicrobial Properties of New Bis-1,3,4-Oxadiazole Derivatives
Four new 1,3,4-bis-oxadiazole derivatives were synthesized, two of them bearing quaternary ammonium salts. The newly synthesized...
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Synthesis and Investigation of Antidiabetic Response of New Coumarin Derivatives Against Streptozotocin Induced Diabetes in Experimental Rats
A new series of coumarin analogs ( 1a – 1g ) were designed and synthesized. The chemical structures of all compounds were elucidated by IR, 1 H NMR, 13 C...
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Microwave-Assisted Synthesis, In Vivo Anti-Inflammatory and In Vitro Anti-Oxidant Activities, and Molecular Docking Study of New Substituted Schiff Base Derivatives
In view of considerable interest in the design and synthesis of new heterocyclic compounds with promising biological activities for medical and...
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Synthesis and Biological Activity of 2-Mercapto-7,10-Dimethyl-3H-Spiro[Benzo[H]Quinazoline-5,1′-Cyclopentane]-4(6H)-One from Ethyl 4′-Amino-5′,8′-Dimethyl-1′H-Spiro[Cyclopentane-1,2′-Naphthalene]-3′-Carboxylate
A synthetic method for 7,10-dimethyl-2-thioxo-2,3-dihydro-1 H -spiro[benzo[ h ]quinazoline-5,1′-cyclopentane]- 4(6 H )-one from ethyl...
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Novel hybrids of drug with bioactive heterocycles for enhancing biological activity
A novel series of aceclofenac hybridised with 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles were designed using molecular hybridization approach and...
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A One-Pot and Efficient Synthesis of Zoledronic Acid Starting from Tert-butyl Imidazol-1-yl Acetate
A one-pot synthesis of zoledronic acid in high yield is described. The procedure involves a non-aqueous ester cleavage of the tert -butyl...
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Synthesis and Neurotropic Activity of New Pyrimido[4′,5′:4,5]Thieno[2,3-b]Quinoline Derivatives
New methods for preparing pyrimido[4′,5′:4,5]thieno[2,3- b ]quinoline derivatives based on 3-cyanohexahydro-2-quinoline were developed. The neurotropic...
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Fluorinated pyrrole incorporated 2-thiazolyl hydrazone motifs: a new class of antimicrobial and anti tuberculosis agents
In aim of obtaining novel bio-active compounds, a new series of fluorinated 1-(4-(aryl)thiazol-2-yl)-2-((1-(aryl)-2,5-dimethyl-1 H -pyrrol-3-yl)methylen...
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Synthesis of 16β-Methylpregn-4,9(11)-Diene-17α-Ol-3,20-Dione From 9α-Hydroxyandrostenedione
An efficient synthesis of 16β-methyl-pregn-4,9(11)-diene-17α-ol-3,20-dione from 9α-hydroxyandrostenedione via its ∆ 9 -analog has been developed....
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Alternative Road for Synthesis of 16α,17α-Epoxy-Pregn-4,9(11)-Dien-21-Ol-3,20-Dione From 9α-Hydroxy-Androstenedione
An alternative efficient road for the synthesis of 16α,17α-epoxy-pregn-4,9(11)-dien-21-ol-3,20-dione from 9α-hydroxy-androst-4-ene-3,17-dione via its...
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Synthesis and biological evaluation of 2′-substituted-4′-selenoribofuranosyl pyrimidines as antitumor agents
AbstractThe 2′-substituted-4′-selenoribofuranosyl pyrimidines 3a – 3j were synthesized from D-ribose and assayed for anticancer activity. The 2′-azido...
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Alternative Road for Synthesis of 16α,17α-Epoxy-Pregn-4,9(11)-Dien-21-ol-3,20-Dione from 9α-Hydroxy-Androstenedione
An alternative efficient road for the synthesis of 16α,17α-epoxy-pregn-4,9(11)-dien-21-ol-3,20-dione from 9α-hydroxy-androst-4-ene-3,17-dione via its...
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Synthesis and Anticonvulsive Activity of 7-Amino-Substituted Cyclopenta[4′,5′]-pyrido[3′,2′:4,5]furo[3,2-d]pyrimidines
Methods for the synthesis of new cyclopenta[4′,5′]pyrido[3′,2′:4,5]furo[3,2- d ]pyrimidine derivatives based on 3-oxo-derivatives of cyclopenta[ c ]pyridi...