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Pharmacological Aspects of the Use of Lipoic Acid (Review)
Lipoic (thioctic) acid (LA) [ R -5-(1,2-dithiolan-3-yl)pentanoic acid] is a natural compound that enters the human body with food. LA is used to treat...
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Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
Alpha-lipoic acid is an organic, sulfate-based compound produced by plants, humans, and animals. As a potent antioxidant and a natural dithiol...
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Antioxidant and Genoprotective Properties of α-Lipoic (Thioctic) Acid in Blood Serum Under X-Ray Exposure
α-Lipoic (thioctic) acid (ALA), which is used as a drug for the treatment of diabetic and alcoholic neuropathy and several other diseases, was found...
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Phytochemical Profiling and In Vitro Antioxidant, Antimicrobial, Cytotoxicity Effects of Some Glycyrrhiza Species from Turkey
Glycyrrhiza (licorice) species, known as “the grandfather of herbs” is one of the most popular medicinal plants used in traditional medicines and...
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Faecal Untargeted Metabolomics Analysis Elucidates the Antihyperglycaemic Effect of Surfactin in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Mice
Type 2 diabetes mellitus is accompanied by hyperglycaemia, liver dysfunction and intestinal dysbiosis. Bioactive peptides, as functional food,...
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Marine Bacteria from the Southeast Coast of Brazil as a Source of Insecticidal Compounds
Vector-borne diseases are public health concerns in equatorial, tropical, and subtropical regions. Controlling their vectors remains the main...
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Synthesis of Conjugates of the Alkaloids Cytisine and Lupinine
New potentially biologically active conjugates of the quinolizidine alkaloids cytisine and lupinine linked through succinic or glutaric acid were...
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Chemical Compositions and Antimutagenic Effects of Ethanolic Extracts of Stachys Thirkei and Stachys Annua subsp. Annua Using the Ames Assay
In this study, antimutagenic effects of ethanolic extracts of Stachys thirkei and Stachys annua subsp. annua belonging to Lamiaceae family that grow...
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Alpha lipoic acid and metformin alleviates experimentally induced insulin resistance and cognitive deficit by modulation of TLR2 signalling
BackgroundObesity is commonly found to be co-morbid with type 2 Diabetes Mellitus. In obese diabetic patients, TLR-2 receptor induced inflammation...
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Dereplication Analysis and Antitrypanosomal Potential of the Red Sea Sponge Amphimedon sp. Supported by Molecular Modelling
The present investigation was oriented to the discovery of chemical compounds from the Red Sea sponge Amphimedon sp., as a source of active agents...
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Synthesis and Cytotoxic Activity of a Series of Functionalized Maleopimarimides
New functionalized maleopimarimides were prepared. Their cytotoxicity against tumor cell lines (HeLa, HEp-2) was studied. Diterpenoids 6, 9 , and 10 ...
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Synthesis, Structure, and Properties of New Lupinine O-Acyl Derivatives
Acylation of the alkaloid lupinine produced O- cinnamoyllupinine and O- lipoyllupinine. The structure of O -cinnamoyllupinine was established by an...
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Bingel Cycloaddition of N-Maleopimarimide-Substituted Amino-Acid Chloromethylketones to Fullerene C60
Lipophilic conjugates of fullerene C 60 were prepared via Bingel [2+1]-cycloaddition of chloromethylketones based on N -maleopimarimide-substituted...
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Synthetic cannabinoids are substrates and inhibitors of multiple drug-metabolizing enzymes
Synthetic cannabinoids, a new class of psychoactive substances, are potent agonists of cannabinoid receptors, which mimic the psychoactive effects of...
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New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats
BackgroundDextran sulfate sodium (DSS)-induced colitis is the most widely used model that resembles ulcerative colitis (UC) in human with challenging...
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Population pharmacokinetic modelling of valproic acid and its selected metabolites in acute VPA poisoning
BackgroundValproic acid (VPA) is a first-line antiepileptic drug. It is used in the treatment of many different types of partial and generalized...
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Phytochemistry and antimicrobial activity of Campomanesia adamantium
Campomanesia adamantium (Cambess.) O. Berg., Myrtaceae, is a plant popularly used for its antiinflammatory, anti-diarrhoeal and urinary antiseptic...
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Effects of alpha-lipoic acid on expression of iron transport and storage proteins in BV-2 microglia cells
BackgroundThe antioxidant properties of alpha-lipoic acid (ALA) are associated with its ability to reduce iron in cells and tissues, which is partly...