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Cinnamic Acid Improves Glucose Uptake and Utilization with Concomitant Improvement of Redox and Bioenergetic Homeostasis, While Modulating Glucose-Lipid Metabolic Switch in Isolated Psoas Muscle
The antidiabetic properties of cinnamic acid was investigated in isolated psoas muscles from Sprague Dawley male rats, by studying its ability to...
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Targeting dysregulated lipid metabolism in the tumor microenvironment
The reprogramming of lipid metabolism and its association with oncogenic signaling pathways within the tumor microenvironment (TME) have emerged as...
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Neuroendocrine microRNAs linked to energy homeostasis: future therapeutic potential
The brain orchestrates whole-body metabolism through an intricate system involving interneuronal crosstalk and communication. Specifically, a key...
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Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
BackgroundThe use of amphotericin B (AmB) in the therapy of systemic mycosis is associated with strong side effects, including nephrotoxicity, and...
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Lipid-lowering drugs and cancer: an updated perspective
Statins and non-statin medications used for the management of dyslipidemia have been shown to possess antitumor properties. Since the use of these...
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Essential phospholipids impact cytokine secretion and alter lipid-metabolizing enzymes in human hepatocyte cell lines
BackgroundEssential phospholipids (EPL) are hepatoprotective.
MethodsThe effects on interleukin (IL)-6 and -8 secretion and on certain...
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2-Geranyl-1-methoxyerythrabyssin II alleviates lipid accumulation and inflammation in hepatocytes through AMPK activation and AKT inhibition
A growing proportion of the global adult and pediatric populations are currently affected by nonalcoholic steatohepatitis (NASH), leading to rising...
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Tartary Buckwheat Flavonoids Relieve Non-alcoholic Fatty Liver Disease by Inhibiting Lipid Accumulation, Inflammation, and Regulating Intestinal Flora
Non-alcoholic fatty liver disease is characterized by liver damage and steatosis, which is often accompanied by inflammation. Tartary buckwheat...
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Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism
BackgroundNon-alcoholic steatohepatitis (NASH) is a progressive subtype of non-alcoholic fatty liver disease (NAFLD) that is closely related to...
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Quercetin-3-O-rutinoside from Moringa oleifera Downregulates Adipogenesis and Lipid Accumulation and Improves Glucose Uptake by Activation of AMPK/Glut-4 in 3T3-L1 Cells
Natural product-based therapeutic alternatives have drawn immense interest to deal with growing incidence of metabolic disorders. Rutin (quercetin-3- O ...
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Effect of statins on lipid metabolism-related microRNA expression in HepG2 cells
BackgroundStatins are potent cholesterol-lowering drugs that prevent cardiovascular events. microRNAs (miRNAs) modulate the expression of genes...
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Pharmacogenomics of statins: lipid response and other outcomes in Brazilian cohorts
Statins are inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in cholesterol biosynthesis, that are highly effective in reducing...
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Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism
Metabolic disturbances in the brain are assumed to be early changes involved in the pathogenesis of depression, and these alterations may be...
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The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is a persistent metabolic disorder marked by deficiencies in insulin secretion and/or function, affecting various...
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Oleuropein as a Therapeutic Agent for Non-alcoholic Fatty Liver Disease During Hepatitis C
Hepatitis C is defined as an infection of hepatocytes by the hepatitis C virus that affects hepatocellular signaling pathways and can lead to...
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Linalool Mitigated High-Fat Diet–Induced Non-alcoholic Fatty Liver Disease by Regulating the Intestinal-Hepatic Axis via TGF-β/NF-kB/TLR4/ZO-1 Pathway
Non-alcoholic fatty liver disease is a persistent state and frequently accompanied by inflammation and disruption of the energy balance at the...
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Zerumbone-Loaded Nanostructured Lipid Carrier Gel Facilitates Wound Healing in Rats
Zerumbone, a natural lipophilic compound from Zingiber zerumbet (L.) Roscoe ex Sm., Zingiberaceae, has anti-inflammatory effects. The study...
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Interplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression
Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming an increasingly pressing global health challenge, with increasing...
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Hygrophila auriculata Improves Insulin Resistance by Reducing Oxidative Stress, Membrane Stabilization and Increasing Hepatic Heat Shock Protein 70 (Hsp70) Expression
The present study aimed to evaluate the effect of the methanolic extract of Hygrophila auriculata (Schumach.) Heine, Acanthaceae, in obesity-induced...
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Non-alcoholic fatty liver disease and liver secretome
Metabolism of carbohydrates and lipids and protein degradation occurs in the liver and contributes to the body's homeostasis by secreting a variety...
