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Development of a Simple Isocratic HPLC-UV Method for the Simultaneous Analysis of Repaglinide and Metformin Hydrochloride in Nanoemulsion Formulations and Commercial Tablets
This study was aimed to develop and validate an HPLC-UV method for simultaneous analysis of metformin HCl (MET HCl) and repaglinide (REP) in...
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Using the Design of Experiments for Development, Validation, and Optimization of HPLC-UV Assay of Tamoxifen Citrate in Polymeric Nanoparticles
A high-performance liquid chromatography method has been developed, optimized and validated as per ICH guidelines for the measurement of tamoxifen...
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Chemical Composition of the Essential Oil of Euphorbia guyoniana Boiss. et Reut.
To our knowledge, this study represents the first investigation into the chemical composition of the essential oil of Euphorbia guyoniana Boiss. et...
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Development and Validation of Stability Indicating RP-HPLC Method for Simultaneous Determination of Chlorthalidone and Amlodipine Besylate in Bulk and in Tablet Dosage Form
Rapid, simple, and novel isocratic reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed with stability, indicating...
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UHPLC Method for Quantification of Bioactive Components in Fenugreek Herbal Preparations
Trigonella foenum-graecum L., Fabaceae, also known as fenugreek, is a popular herb commonly used as a spice, flavoring, and medicinal agent. It is...
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Response Surface Optimised Bioanalytical Stability Indicating LC-UV Method for the Estimation of Emtricitabine and Efavirenz with Internal Standard
This work was aimed at the development of response surface optimised bioanalytical stability indicating the LC-UV method for the estimation of drugs...
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Development of a Bioanalytical Method by UHPLC-ESI-TQD-MS for the Quantification of Digoxin in Plasma
A bioanalytical method was developed and validated for digoxin. The method was extremely sensitive and without adduct formation by ultra-performance...
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Study of Organ Uptake of the New Hepatotropic Paramagnetic Contrast Agent, the Mn(II) Complex of 2-[2-Carboxymethyl-(4-Hexadecyloxyphenylcarbamoylmethyl)-Aminoethyl]-Aminoethyl-(4-Hexadecyloxyphenylcarbamoylmethyl)-Aminoacetic Acid (Mn-DTPA-GDOF), In Vivo in Some Experimental Models of Liver Damage in Rats
The results of studying magnetic resonance imaging (MRI) of rat liver performed with the original hepatotropic paramagnetic contrast agent (PMCA)...
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Simultaneous Analysis of Atorvastatin and Rosuvastatin by LC-MS: Development, Validation, and Application of the Proposed Method to Analysis of Atorvastatin Pharmacokinetics in Pakistani Population
The present work has been done as part of optimization procedures aimed at develo** a sensitive HPLC-MS method with good precision and accuracy for...
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Determination of Coumarins from Pterocaulon balansae by an Ultra-Fast Liquid Chromatography Method in Topical Applications
Coumarins from Pterocaulon balansae Chodat, Asteraceae, have received increasing attention due to their biological activities, especially for the...
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Recycling Preparative Liquid Chromatography, the Overlooked Methodology for the Purification of Natural Products
Frequently, preparative high-performance liquid chromatography separations of complex natural product mixtures by adsorption chromatography are...
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MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments
BackgroundSynthetic cathinones (SC) constitute the second most frequently abused class of new psychoactive substances. They serve as an alternative...
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Quantitative Determination of Methotrexate, 7-Hydroxymethotrexate, and Methotrexate Polyglutamates in Human Erythrocytes by High-Performance Liquid Chromatography with Mass Spectrometry
Methotrexate is the drug of choice for the treatment of rheumatoid arthritis. However, some patients have no or an insufficient effect if the...
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Novel Psoriasis Treatment: Development and Evaluation of a Thermo-Sensitive Pro-Penetrating Hydrogel Based on Coptis chinensis and Phellodendron amurense
Psoriasis is a chronic papulosquamous skin disease whose current treatments have severe side effects, which limits their long-term application....
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Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools
Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With...
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Danggui Buxue Tang Alleviates Antibiotic-Induced Intestinal Structural Disorders by Affecting Intestinal Bacterial Composition and Thus Bile Acid Metabolism
This work was aimed to explore the mechanism of Danggui Buxue Tang (DBT) in restoring intestinal disorder. For this purpose, an intestinal damage...
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Study of Chemical Composition, Anticholinesterase and Antioxidant Properties of Essential Oil and Ethanolic Extract from Thymus Numidicus Poiret, an Algerian Endemic Medicinal Plant
This study is aimed to evaluating the anticholinesterase and antioxidant properties of essential oil (EO) and ethanolic extract (EE) from Thymus...
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Seasonal Chemical Variability of Aloysia polystachya Leaves
The use of natural products as food ingredients requires adequate regulation and safety assessment for its legal commercialization. Aloysia polystachya ...
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Cordia dichotoma Fruits Aqueous Extracts Alleviates Depressive-Like Behavior in a Rat Model via Regulating Serotonergic Neurotransmitters
Depression is a common mental illness caused by the interaction of social, psychological, and physical factors. The number of people suffering from...
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A Method for Assay of Losartan, Its Active Metabolite E-3174, and Glibenclamide in Human Serum and Urine by HPLC-MS/MS
A simple, rapid, and reliable method for simultaneous assay of losartan, its active metabolite E-3174, and glibenclamide was developed and validated....
