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Structure–Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges
Indonesian marine natural products have been one of the most promising sources in the race to obtain potential drugs for cancer treatment. One of the...
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Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells
BackgroundMultifunctional thiosemicarbazones (TSCs) able to bind sigma receptors and chelate metals are considered as a promising avenue for the...
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In Vitro Study of the Cytotoxic and Immunotropic Effects of Molnupiravir and Favipiravir
The effects of the antiviral drugs molnupiravir and favipiravir on the viability of human embryonic lung cells and the production of cytokines by...
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Cytotoxic Activity of Perfluoroalkyl-Substituted Imidazoindazoles and Imidazobenzisoxazoles
The cytotoxic activity of perfluoroalkyl imidazoindazoles and imidazobenzisoxazoles with respect to MCF-7 (human breast carcinoma) and HepG2 cell...
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AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis
BackgroundDespite great advances in our understanding of the impact of cannabinoids on human organism, many of their properties still remain...
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In Vitro Evaluation of Antioxidant, Antimicrobial, Cytotoxic, Anti-Inflammatory, Anti-Aging, Enzyme Inhibition Potential, and HPLC Analysis of Traditionally Used Plant Delphinium Uncinatum Wall
Delphinium uncinatum Wall. (Ranunculaceae) is a native medicinal plant found on the sub-continent that is utilized to cure various human diseases....
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Macroporous Resin-Assisted Enrichment and Isolation of Antioxidant and Cytotoxic Phenolics from Penthorum chinense
Penthorum chinense Pursh, Penthoraceae, is a well-known functional food and an herbal remedy in traditional Chinese medicine with a long history of...
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Protection of the hematopoietic system against radiation-induced damage: drugs, mechanisms, and developments
Sometimes, people can be exposed to moderate or high doses of radiation accidentally or through the environment. Radiation can cause great harm to...
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In Vitro Antioxidant Activity of Asteriscus Graveolens (Forsk.) and Its Protective Effect on Doxorubicin-Induced Hepatotoxicity and Testicular Oxidative Damage in Rats
Asteriscus graveolens (Asteraceae) is a medicinal herb, used in Algeria to treat diabetes, hypertension, pain, fever, inflammation and...
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In Vitro Evaluation of Anti-Angiogenic Efficacy, Cell Migration Activity and Cell Survival Effect Against Hydrogen Peroxide-Induced Damage of Prunetin
Anti-angiogenic isoflavonoids are gaining attention as a novel approach in the prevention and treatment of tumor progression and metastasis. These...
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Enhancement of the Cytotoxic Effect of Doxorubicin on Tumor Cells Upon Exposure to Atmospheric Cold Plasma
The possibility of enhancing the cytotoxic effect of doxorubicin on tumor cells with the aid of additional exposure to atmospheric cold plasma is...
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Alkaloids from the Leaves of Annona crassiflora and Their Cytotoxic Activity
Aporphines are a class of alkaloids mostly reported in Magnoliids. The genus Annona , Annonaceae, presents great structural diversity of these...
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Cannabis Extracts and Their Cytotoxic Effects on Human Erythrocytes, Fibroblasts, and Murine Melanoma
Most of the pharmacological effects of Cannabis species have been attributed to their cannabinoid constituents, primarily Δ 9 -tetrahydrocannabinol and...
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Modulation of DNA damage response by targeting ATM kinase using newly synthesized di-phenoxy acetamide (DPA) analogs to induce anti-neoplasia
BackgroundImbalance and instability in the structure of the DNA have become major characteristics of cancer. In response to DNA damage, DNA damage...
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Evaluation of the Cytotoxic Effect of Thymol Loaded Albumin-Coated Fe3O4 Magnetic Nanoparticles on MDA-MB-231 Cell Line and the Expression of Autophagic MAP1LC3A Gene
Thymol has antioxidant, apoptotic, anti-cancer and, anti-inflammatory properties. In this study iron oxide nanoparticles were synthetized by chemical...
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Analysis of the Mechanisms of Action of a TSPO Ligand (GML-3 Compound) in a Model of Lipopolysaccharide-Induced Cell Damage
The ability of an 18-kDa translocator protein (TSPO) ligand, a pyrrolo[1,2- a ]pyrazine derivative, represented by N -butyl- N -methyl-1-phenylpyrrolo[1,2-
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Ameliorative Effect of Polysaccharide Rich Fraction from Eulophia herbacea Against Methotrexate Induced Liver Damage in Rats
The present study was aimed to investigate a protective effect of polysaccharide rich fraction from Eulophia herbacea Lindl. tubers against...
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Protective Activity of Cubebin from Syringa oblata Against CCl4-Induced Hepatic Damage in Mice
The purpose of this study was to evaluate the hepatoprotective activity of cubebin isolated from Syringa oblata Lindl., Oleaceae, on hepatic damage...
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Antitumor Effects of Annopurpuricin A, an Acetogenin from the Roots of Annona purpurea
Annona purpurea Moc. & Sessé ex Dunal, Annonaceae, is a plant species found in the Mexican Pacific coast. Based on ethnomedical information,...
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Thymol induces mitochondrial pathway-mediated apoptosis via ROS generation, macromolecular damage and SOD diminution in A549 cells
BackgroundThymol is a monoterpene phenol found in thyme species plants. The present study was carried out to investigate the effect of thymol and its...
