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Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases
Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A...
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A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice
BackgroundIA-0130 is a derivative of 3-(1,3-diarylallylidene)oxindoles, which is a selective estrogen receptor modulator (SERM). A previous study...
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Investigation of the Antinociceptive and Gastroprotective Potential of the Flavonoid Tricin and its Possible Mechanism of Action
Tricin is a flavonoid that occurs in monocotyledonous plants and exhibits a broad pharmacological spectrum, including anti-inflammatory and...
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Qualitative Analysis of Inquiries Received by FDA Regarding Conduct of Clinical Trials during the Covid-19 Public Health Emergency
BackgroundThis report describes the U.S. Food and Drug Administration (FDA) experience in establishing a dedicated mailbox, and in publishing related...
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Multi-layered metabolic effects of trehalose on the liver proteome in apoE-knockout mice model of liver steatosis
BackgroundMetabolic dysfunction-associated fatty liver disease has been well documented as a key independent risk factor for the development of...
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Use of Seamless Study Designs in Oncology Clinical Development– A Survey Conducted by IDSWG Oncology Sub-team
Seamless study designs have the potential to accelerate clinical development. The use of innovative seamless designs has been increasing in the...
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Patient and Public Perceptions in Canada About Decentralized and Hybrid Clinical Trials: “It’s About Time we Bring Trials to People”
BackgroundLittle is known about patient and the public perspectives on decentralized and hybrid clinical trials in Canada.
MethodsWe conducted an...
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Luteolin for neurodegenerative diseases: a review
Neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and multiple sclerosis affect millions of people...
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The effect of phencyclidine-mediated blockade of NMDA receptors in the early postnatal period on glutathione and sulfur amino acid levels in the rat brain as a potential causative factor of schizophrenia-like behavior in adulthood
BackgroundPhencyclidine, an NMDA receptor antagonist, is frequently used to model behavioral and neurochemical changes correlated with schizophrenia...
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β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo
Backgroundβ -carboline alkaloids exert a distinguished ability to impair cell growth and induce cell death in a variety of cancers and the evaluation...
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Harmonizing Quality Improvement Metrics Across Global Trial Networks to Advance Paediatric Clinical Trials Delivery
BackgroundDespite global efforts to improve paediatric clinical trials, significant delays continue in paediatric drug approvals. Collaboration...
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Challenges and opportunities of develo** small-molecule therapies for age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of vision loss in senior adults. The disease can be categorized into two types: wet AMD...
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Zuranolone in postpartum depression: a profile of its use in the USA
Zuranolone (ZURZUVAE ® ), an orally bioavailable neuroactive steroid and a selective, positive, allosteric modulator of both synaptic and extrasynaptic...
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The role of glucagon-like peptide-1/GLP-1R and autophagy in diabetic cardiovascular disease
Diabetes leads to a significantly accelerated incidence of various related macrovascular complications, including peripheral vascular disease and...
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In vitro biological evaluation of a novel folic acid-targeted receptor quantum dot−β−cyclodextrin carrier for C−2028 unsymmetrical bisacridine in the treatment of human lung and prostate cancers
BackgroundTraditional small-molecule chemotherapeutics usually do not distinguish tumors from healthy tissues. However, nanotechnology creates...
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Add or switch to systemics and biologics where topical paediatric hidradenitis suppurativa therapy fails
Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin condition that typically develops in adults but can rarely affect...
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Overdosage Section in US and EU Labeling
The Prescribing Information (PI) in the United States (US) and the Summary of Product Characteristics (SmPC) in the European Union (EU) are approved...
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The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver
BackgroundOur recent studies showed that prolonged administration of novel atypical antipsychotics affected the expression and activity of cytochrome...
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Anti-elastase, Anti-tyrosinase, and Anti-inflammatory Activities of Three Compounds Isolated from Psorospermum aurantiacum: In Silico and In Vitro Assays
The hexane fraction of Psorospermum aurantiacum Engl., Hypericaceae, was found to prevent photo aging in skin cells lines. Therefore, this research...
