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Genetic variations in tumor-suppressor miRNA-encoding genes and their target genes: focus on breast cancer development and possible therapeutic strategies
MicroRNAs (miRNAs) negatively affect gene expression by binding to their specific mRNAs resulting in either mRNA destruction or translational...
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Differential expression profiling of onco and tumor-suppressor genes from major-signaling pathways in Wilms’ tumor
PurposeWilms’ tumor is the most-frequent malignant-kidney tumor in children under 3–4 years of age and is caused by genetic alterations of oncogenes...
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The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes
Epigenetic regulators are frequently mutated in hematological malignancies including acute myeloid leukemia (AML). Thus, the identification and...
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Investigation of the effects of the royal jelly on genomic demethylation and tumor suppressor genes in human cancer cells
Royal jelly is a gelatinous nutrient secretion produced by the mandibular glands of young worker honey bees and has a critical role in honey bee...
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CUL4B functions as a tumor suppressor in KRAS-driven lung tumors by inhibiting the recruitment of myeloid-derived suppressor cells
Lung cancer is the leading cause of cancer-related death worldwide. KRAS mutations are the most common oncogenic alterations found in lung cancer....
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Significance of promoter methylation of multiple tumor suppressor genes in hepatocellular carcinoma
BackgroundMethylation of the promoter at CpG islands is a mechanism of silencing tumor suppressor genes and therefore enhances cancer progression....
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Tumor-infiltrating monocytic myeloid-derived suppressor cells contribute to the development of an immunosuppressive tumor microenvironment in gastric cancer
BackgroundGastric cancer (GC) is characterized by an immunosuppressive and treatment-resistant tumor immune microenvironment (TIME). Here, we...
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3′untranslated regions of tumor suppressor genes evolved specific features to favor cancer resistance
Cancer-related genes have evolved specific genetic and genomic features to favor tumor suppression. Previously we reported that tumor suppressor...
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Genome-wide CRISPR knockout screening identified G protein pathway suppressor 2 as a novel tumor suppressor for uveal melanoma metastasis
PurposeUveal melanoma (UM) is the most common intraocular malignant tumor in adults. Due to the lack of effective treatments for metastatic UM, the...
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A Comprehensive Bioinformatic Analysis Identifies a Tumor Suppressor Landscape of the MEG3 lncRNA in Breast Cancer
Breast cancer (BC) is the leading cause of cancer mortality in women and a major risk to world health. Therefore, effective strategies are required...
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Lysine metabolism is a novel metabolic tumor suppressor pathway in breast cancer
The International Agency for Research on Cancer determined that obesity is the primary preventable cause of breast cancer. The nuclear receptor...
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CPLX2 is a novel tumor suppressor and improves the prognosis in glioma
BackgroundGlioma is a type of malignant cancer that affect the central nervous system. New predictive biomarkers have been investigated in recent...
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Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion
Paradoxically, tumor development and progression can be inhibited and promoted by the immune system. After three stages of immune editing, namely,...
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A novel LINC00478 serves as a tumor suppressor in endometrial carcinoma progression
BackgroundLong noncoding RNAs (lncRNAs) are involved in the pathogenesis and progression of various cancers, but their roles in endometrial cancer...
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Tumor suppressor p53 modulates activity-dependent synapse strengthening, autism-like behavior and hippocampus-dependent learning
Synaptic potentiation underlies various forms of behavior and depends on modulation by multiple activity-dependent transcription factors to...
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Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer: Integrating Bioinformatics Analysis with Experimental Confirmation
ObjectiveTo uncover the mechanisms underlying the development of colorectal cancer (CRC), we applied bioinformatic analyses to identify key genes and...
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TMPRSS2 is a tumor suppressor and its downregulation promotes antitumor immunity and immunotherapy response in lung adenocarcinoma
BackgroundTMPRSS2, a key molecule for SARS-CoV-2 invading human host cells, has an association with cancer. However, its association with lung cancer...
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Distinct power of bone marrow microRNA signatures and tumor suppressor genes for early detection of acute leukemia
BackgroundAcute leukemia involving lymphocytic and myeloid cells is cancer with a high mortality rate. Swift and timely diagnosis might be a...
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Germline variants in the Von Hippel-Lindau tumor suppressor gene in Cuban patients
BackgroundVon Hippel-Lindau (VHL) syndrome is an autosomal dominantly inherited disorder that predisposes to multiple neoplasms. Patients may develop...
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Bioinformatics-based screening and analysis of the key genes involved in the influence of antiangiogenesis on myeloid-derived suppressor cells and their effects on the immune microenvironment
This study aimed to screen differentially expressed genes (DEGs) involved in the influence of antiangiogenic therapy on myeloid-derived suppressor...
