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Superior semicircular canal dehiscence postoperative outcomes: a case series of 350 repairs
BackgroundSuperior Semicircular Canal Dehiscence (SSCD) is a dehiscence of the otic capsule which normally lies over the superior semicircular canal....
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Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability
Reaction time variability (RTV), reflecting fluctuations in response time on cognitive tasks, has been proposed as an endophenotype for many...
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Phenotypic and ancestry-related assortative mating in autism
BackgroundPositive assortative mating (AM) in several neuropsychiatric traits, including autism, has been noted. However, it is unknown whether the...
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Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study
The aetiology of conduct problems involves a combination of genetic and environmental factors, many of which are inherently linked to parental...
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Identification of a novel risk factor for chronic wasting disease (CWD) in elk: S100G single nucleotide polymorphism (SNP) of the prion protein gene (PRNP)
Prion diseases are fatal and malignant infectious encephalopathies induced by the pathogenic form of prion protein (PrP Sc ) originating from benign...
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Sleep disturbances in ADHD: investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes
Sleep disturbances are common in attention deficit hyperactivity disorder (ADHD) and associated with poor outcomes. We tested whether, in children...
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Family-based analysis of the contribution of rare and common genetic variants to school performance in schizophrenia
Impaired cognition in schizophrenia is associated with worse functional outcomes. While genetic factors are known to contribute to variation in...
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Association analysis of miRNA-146a and miRNA-499 polymorphisms with rheumatoid arthritis: a case–control and trio-family study
Single nucleotide polymorphism is known to alter the expression and processing of miRNAs leading to a variety of diseases including rheumatoid...
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Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya
Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region...
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Examining the source of increased bipolar disorder and major depressive disorder common risk variation burden in multiplex schizophrenia families
Psychotic and affective disorders often aggregate in the relatives of probands with schizophrenia, and genetic studies show substantial genetic...
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Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems
Anxiety and depression (emotional disorders) are familial and heritable, especially when onset is early. However, other cross-generational studies...
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Missing Causality and Heritability of Autoimmune Hepatitis
BackgroundAutoimmune hepatitis has an unknown cause and genetic associations that are not disease-specific or always present. Clarification of its...
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Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations
The protein α-synuclein, a key player in Parkinson’s disease (PD) and other synucleinopathies, exists in different physiological conformations:...
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Novel polymorphisms in the prion protein gene (PRNP) and stability of the resultant prion protein in different horse breeds
Prion diseases are fatal neurodegenerative disorders in which the main pathogenic event is the conversion of the cellular prion protein (PrP C ) into...
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A multi-ancestry cerebral cortex transcriptome-wide association study identifies genes associated with smoking behaviors
Transcriptome-wide association studies (TWAS) have provided valuable insight in identifying genes that may impact cigarette smoking. Most of previous...
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Audiovestibular and vaccination complications of COVID-19
ObjectivesSince its first appearance in Wuhan December 2019, SARS-CoV2 virus received great attention due to its severe symptoms and high spread...
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Genetic structure of Aedes albopictus (Diptera: Culicidae) populations in China and relationship with the knockdown resistance mutations
BackgroundMosquito control is needed to prevent dengue fever, which is mainly spread by Aedes albopictus in China. Application of insecticides is...
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Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan
BackgroundCluster headache is a highly debilitating neurological disorder with considerable inter-ethnic differences. Genome-wide association studies...
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Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder
DDR1 has been linked to schizophrenia (SCZ) and bipolar disorder (BD) in association studies. DDR1 encodes 58 distinct transcripts, which can be...
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Couples and families’ resilience in facing sociocultural changes: “Co-maternity” and “Oedipus in law” in the Tunisian transitional context
When a nation has experienced state violence and political exploitation, relationships in families and between couples are severely strained....