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Application of transposon systems in the transgenesis of bovine somatic and germ cells
BackgroundSeveral DNA transposons including PiggyBac (PB), Slee** Beauty (SB), and Tol2 have been applied as effective means for of transgenesis...
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Frontier Technologies in Bovine Reproduction
This book details the frontier technologies in the area of bovine reproduction. It describes the importance and significance of different...
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Transgenic IDH2R172K and IDH2R140Q zebrafish models recapitulated features of human acute myeloid leukemia
Isocitrate dehydrogenase 2 ( IDH2 ) mutations occur in more than 15% of cytogenetically normal acute myeloid leukemia (CN-AML) but comparative studies...
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Current scenario and challenges ahead in application of spermatogonial stem cell technology in livestock
PurposeSpermatogonial stem cells (SSCs) are the source for the mature male gamete. SSC technology in humans is mainly focusing on preserving...
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SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility
Mesial temporal lobe epilepsy with hippocampal sclerosis and a history of febrile seizures is associated with common variation at rs7587026, located...
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In vivo characterization of a podocyte-expressed short podocin isoform
The most common genetic causes of steroid-resistant nephrotic syndrome (SRNS) are mutations in the NPHS2 gene, which encodes the cholesterol-binding,...
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Regulation of Cardiomyocyte Division During Cardiac Regeneration
Purpose of ReviewThis review explores efforts made over the previous three decades to determine mechanisms of cardiomyocyte cell division. Many...
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Monitoring Immune Cell Function Through Optical Imaging: a Review Highlighting Transgenic Mouse Models
Transgenic mouse models have facilitated research of human diseases and validation of therapeutic approaches. Inclusion of optical reporter genes...
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Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo
The RhoGEF TRIO is known to play a major role in neuronal development by controlling actin cytoskeleton remodeling, primarily through the activation...
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Evaluation of Nav1.8 as a therapeutic target for Pitt Hopkins Syndrome
Pitt Hopkins Syndrome (PTHS) is a rare syndromic form of autism spectrum disorder (ASD) caused by autosomal dominant mutations in the Transcription...
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Dosage sensitivity intolerance of VIPR2 microduplication is disease causative to manifest schizophrenia-like phenotypes in a novel BAC transgenic mouse model
Recent genome-wide association studies (GWAS) have identified copy number variations (CNVs) at chromosomal locus 7q36.3 that significantly contribute...
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Advances in the Molecular and Cellular Biology of Strongyloides spp.
Purpose of ReviewThis paper constitutes an update of recent studies on the general biology, molecular genetics, and cellular biology of Strongyloides ...
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Transintestinal cholesterol excretion in health and disease
Purpose of ReviewThe transintestinal cholesterol efflux (TICE) pathway is the second described route for plasma cholesterol fecal elimination. This...
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CRISPR/Cas9-edited triple-fusion reporter gene imaging of dynamics and function of transplanted human urinary-induced pluripotent stem cell-derived cardiomyocytes
PurposeTo investigate the post-transplantation behaviour and therapeutic efficacy of human urinary-induced pluripotent stem cell-derived...
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Chromosome-scale genome of the human blood fluke Schistosoma mekongi and its implications for public health
BackgroundSchistosoma mekongi is a human blood fluke causing schistosomiasis that threatens approximately 1.5 million humans in the world....
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Application of CRISPR-Cas9 based gene editing to study the pathogenesis of colon and liver cancer using organoids
Two breakthrough techniques that have totally revolutionized biology in last 1 decade are the discovery of genome editing tools and growing the stem...
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Zebrafish live imaging: a strong weapon in anticancer drug discovery and development
Develo** anticancer drugs is a complex and time-consuming process. The inability of current laboratory models to reflect important aspects of the...
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Collaboration between biomedical research and community-based primary health care actors in chronic disease management: a sco** review
BackgroundCollaboration between biomedical research and community-based primary health care actors is essential to translate evidence into clinical...
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Techniques for investigating lncRNA transcript functions in neurodevelopment
Long noncoding RNAs (lncRNAs) are sequences of 200 nucleotides or more that are transcribed from a large portion of the mammalian genome. While...
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