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Panax notoginseng alleviates oxidative stress through miRNA regulations based on systems biology approach
BackgroundHerbal medicine Sanqi (SQ), the dried root or stem of Panax notoginseng (PNS), has been reported to have anti-diabetic and anti-obesity...
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Comparative proteomic analysis of mustard lung as a complicated disease using systems biology approach
During Iraq-Iran conflict, chemical weapons, particularly SM gas, were used numerous times, whose aftereffects are still present. This study aimed to...
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A hybrid systems biology and systems pharmacology investigation of Zingerone’s effects on reconstructed human epidermal tissues
BackgroundAs individuals live longer, elderly populations can be expected to face issues. This pattern urges researchers to investigate the aging...
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Rituximab and Pyoderma Gangrenosum: An Investigation of Disproportionality Using a Systems Biology-Informed Approach in the FAERS Database
BackgroundStudies have found an increased risk of pyoderma gangrenosum associated with rituximab. The structural properties and...
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Applications of synthetic biology in medical and pharmaceutical fields
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful bioproperties. During the past decades, progresses have...
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A systems biology approach to pathogenesis of gastric cancer: gene network modeling and pathway analysis
BackgroundGastric cancer (GC) ranks among the most common malignancies worldwide. This study aimed to find critical genes/pathways in GC pathogenesis.
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Systems biology in cardiovascular disease: a multiomics approach
Omics techniques generate large, multidimensional data that are amenable to analysis by new informatics approaches alongside conventional statistical...
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The Critical Role of Biomarkers for Drug Development Targeting the Biology of Aging
Alzheimer’s disease is a devastating neurodegenerative disorder that poses a significant societal burden. Approval of anti-amyloid antibody therapies...
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Fourteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer
The fourteenth annual workshop of the European Network for Breast Development and Cancer (ENBDC) on Methods in Mammary Gland Biology and Breast Cancer ...
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Perturbed iron biology in the prefrontal cortex of people with schizophrenia
Despite loss of grey matter volume and emergence of distinct cognitive deficits in young adults diagnosed with schizophrenia, current treatments for...
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AlphaFold2 and its applications in the fields of biology and medicine
AlphaFold2 (AF2) is an artificial intelligence (AI) system developed by DeepMind that can predict three-dimensional (3D) structures of proteins from...
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RNA-binding proteins in cardiovascular biology and disease: the beat goes on
Cardiac development and function are becoming increasingly well understood from different angles, including signalling, transcriptional and...
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Telomere Biology Disorder: A Focus on Gastrointestinal and Hepatic Manifestations
Purpose of ReviewTelomere biology disorders (TBD) encompass several illnesses caused by underlying mutations in telomere maintenance leading to...
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Hallmark discoveries in the biology of Wilms tumour
The modern study of Wilms tumour was prompted nearly 50 years ago, when Alfred Knudson proposed the ‘two-hit’ model of tumour development. Since...
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The expanding incretin universe: from basic biology to clinical translation
Incretin hormones, principally glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1(GLP-1), potentiate meal-stimulated...
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The Mongolian Gerbil as a Useful Experimental Model in Reproductive Biology
Ultimately, the Mongolian gerbils ( Meriones unguiculatus ) have acquired a relevant role in biological and biomedical experiments alongside other...
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Exploring key molecular signatures of immune responses and pathways associated with tuberculosis in comorbid diabetes mellitus: a systems biology approach
BackgroundComorbid type 2 diabetes mellitus (T2DM) increases the risk for tuberculosis (TB) and its associated complications, although the...
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Bone Trans-omics: Integrating Omics to Unveil Mechanistic Molecular Networks Regulating Bone Biology and Disease
Purpose of ReviewRecent advancements in “omics” technologies and bioinformatics have afforded researchers new tools to study bone biology in an...
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Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)
BackgroundPatients with non-alcoholic fatty liver disease (NAFLD) may be more susceptible to coronavirus disease 2019 (COVID-19) and even more likely...
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Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development
The fast-develo** synthetic biology (SB) has provided many genetic tools to reprogram and engineer cells for improved performance, novel functions,...
