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Assessing the Cntnap2 knockout rat prepulse inhibition deficit through prepulse scaling of the baseline startle response curve
Many neurodevelopmental disorders, including autism spectrum disorder (ASD), are associated with changes in sensory processing and sensorimotor...
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Intermittent theta-burst stimulation to the right dorsolateral prefrontal cortex may increase potentiated startle in healthy individuals
Repetitive transcranial magnetic stimulation (rTMS) treatment protocols targeting the right dlPFC have been effective in reducing anxiety symptoms...
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A midbrain-reticulotegmental circuit underlies exaggerated startle under fear emotions
Exaggerated startle has been recognized as a core hyperarousal symptom of multiple fear-related anxiety disorders, such as post-traumatic stress...
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Advances in hyperekplexia and other startle syndromes
Startle, a basic alerting reaction common to all mammals, is described as a sudden involuntary movement of the body evoked by all kinds of sudden and...
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Involvement of the thalamic reticular nucleus in prepulse inhibition of acoustic startle
Thalamic reticular nucleus (TRN) is a group of inhibitory neurons surrounding the thalamus. Due to its important role in sensory information...
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Emotional Processing and Maltreatment During Childhood as Factors of Vulnerability to Alcohol Abuse in Young Adults
Different studies suggest a strong association between childhood abuse and alcohol use disorders (AUDs). The modulation of the startle response has...
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Robust and replicable measurement for prepulse inhibition of the acoustic startle response
Measuring animal behavior in the context of experimental manipulation is critical for modeling, and understanding neuropsychiatric disease. Prepulse...
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Behavioral and brain reactivity to uncertain stress prospectively predicts binge drinking in youth
Prior studies show that individuals with alcohol use disorder exhibit exaggerated behavioral and brain reactivity to uncertain threats (U-threat). It...
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Stimulation of the ventromedial prefrontal cortex blocks the return of subcortically mediated fear responses
The ventromedial prefrontal cortex (vmPFC) mediates the inhibition of defensive responses upon encounters of cues, that had lost their attribute as a...
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Self-Reported and Physiological Reactions to Thin and Non-Thin Bodies: Understanding Motivational Processes Associated with Disordered Eating
BackgroundThe present study examined the relative roles of approach and avoidance motivation in eating pathology using a multi-method approach...
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Prospective longitudinal assessment of sensorimotor gating as a risk/resiliency factor for posttraumatic stress disorder
Little is understood about cognitive mechanisms that confer risk and resiliency for posttraumatic stress disorder (PTSD). Prepulse Inhibition (PPI)...
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Genetic variant reanalysis reveals a case of Sandhoff disease with onset of infantile epileptic spasm syndrome
BackgroundSandhoff disease (SD) i s an autosomal recessive lysosomal disease with clinical manifestations such as epilepsy, psychomotor retardation...
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Acute orexin antagonism selectively modulates anticipatory anxiety in humans: implications for addiction and anxiety
Research indicates that heightened anticipatory anxiety underlies several forms of psychopathology. Anticipatory anxiety can be reliably and...
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Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats
Psilocybin (a classic serotonergic psychedelic drug) has received appraisal for use in psychedelic-assisted therapy of several psychiatric disorders....
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Tics: neurological disorders determined by a deficit in sensorimotor gating processes
Tic related disorders affect 4–20% of the population, mostly idiopathic, can be grouped in a wide spectrum of severity, where the most severe end is...
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Time of exposure to social defeat stress during childhood and adolescence and redox dysregulation on long-lasting behavioral changes, a translational study
Traumatic events during childhood/early adolescence can cause long-lasting physiological and behavioral changes with increasing risk for psychiatric...
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Adolescent exposure to the Spice/K2 cannabinoid JWH-018 impairs sensorimotor gating and alters cortical perineuronal nets in a sex-dependent manner
The consumption of synthetic cannabinoids during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in...
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Attenuating human fear memory retention with minocycline: a randomized placebo-controlled trial
Pavlovian fear conditioning is widely used as a pre-clinical model to investigate methods for prevention and treatment of anxiety and stress-related...
