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Salivary Duct Carcinoma Arising in a Warthin Tumor of the Parotid Gland: A Rare Case Report with Review of Literature and PD-L1 Expression
Warthin’s tumor is the second most common neoplasm of the parotid gland and consists of 2 components, including lymphoid stroma and glandular...
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Prognostic value and clinicopathological roles of the tumor immune microenvironment in salivary duct carcinoma
Salivary duct carcinoma (SDC) is an aggressive type of salivary gland carcinoma. Recently, immunotherapies targeting immune checkpoints, including...
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An Unusually Large Salivary Duct Cyst of Minor Salivary Gland-A Unique Case Report
The obstruction of salivary gland ducts causes salivary duct cysts (SDCs), and their occurrence is rare in minor salivary glands. A 25-year-old male...
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Loss of BAP1 Protein Expression by Immunohistochemistry in the Salivary Duct Carcinoma Component of an Intracapsular Carcinoma ex Pleomorphic Adenoma of the Parotid Gland
BackgroundBRCA1-associated protein 1 ( BAP1 ) is a tumor suppressor gene that is altered in a variety of neoplasms as well as in BAP1 tumor...
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Expression of Mucins in Different Entities of Salivary Gland Cancer: Highest Expression of Mucin-1 in Salivary Duct Carcinoma
Therapeutic options for advanced salivary gland cancer (SGC) are rare. Therefore, it was the aim of this study to investigate the extent and...
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Identification of novel prognostic and predictive biomarkers in salivary duct carcinoma via comprehensive molecular profiling
Molecular targets and predictive biomarkers for prognosis in salivary duct carcinoma (SDC) have not been fully identified. We conducted comprehensive...
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Prognostic models for estimating survival of salivary duct carcinoma: a population-based study
PurposeIn a large salivary duct carcinoma (SDC) cohort, we aimed to investigate the clinical factors influencing their survival outcomes and to...
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Oncocytoid Variant of High-Grade Salivary Duct Carcinoma: A Potential Diagnostic Pitfall. A Report on Two Patients
Salivary duct carcinoma (SDC) is an uncommon and aggressive salivary malignancy. The oncocytoid variant of salivary duct carcinoma (OSDC) has only...
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Pure Apocrine Intraductal Carcinoma of Salivary Glands: Reassessment of Molecular Underpinnings and Behavior
BackgroundIntraductal carcinoma (IDC) of the salivary glands is a confounding entity, our understanding of which continues to evolve. At least four...
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Expression of CD5 in salivary gland tumors: an ancillary marker for carcinoma showing thymus-like differentiation (CASTLE) of the major salivary gland
Recently, cases of carcinoma showing thymus-like differentiation (CASTLE) occurring in major salivary glands have been identified. To assess the...
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The extent of androgen receptor and HER2 expression allows for targeted therapy in most cases of salivary duct carcinoma: analysis of clinical and histopathological data in a tertiary care center
PurposeThe incidence of salivary duct carcinoma (SDC) seems to be underestimated due to inaccurate classification. Further, the frequency of SDC...
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Molecular Aspects of Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma of the Salivary Gland
BackgroundSalivary gland tumors (SGTs) are rare and highly heterogeneous lesions, making diagnosis a challenging activity. In addition, the small...
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Targeted molecular profiling of salivary duct carcinoma with rhabdoid features highlights parallels to other apocrine and discohesive neoplasms: which phenotype should drive classification?
BackgroundSalivary duct carcinoma with rhabdoid features (SDC-RF) is a recently-described salivary gland tumor that bears striking histologic...
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A Pitfall of the Androgen Deprivation Therapy for Salivary Duct Carcinoma: Hormonal Therapy-Induced Castrate-Resistant Prostate Cancer
IntroductionSalivary duct carcinoma (SDC) is a rare, high-grade salivary gland malignancy. Recently, targeting the androgen receptor (AR) is one of...
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Prognosis of primary breast salivary gland-type carcinoma: a propensity score-matching analysis with invasive carcinoma of no special type based on the SEER database for years 2010–2020
BackgroundPrimary breast salivary gland-type carcinoma has weak evidence to support its management due to its rare occurrence and limited data...
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A Subset of Salivary Intercalated Duct Lesions Harbors Recurrent CTNNB1 and HRAS Mutations: A Molecular Link to Basal Cell Adenoma and Epithelial-Myoepithelial Carcinoma?
BackgroundIntercalated duct lesions (IDLs) are benign salivary gland proliferations that resemble normal intercalated ducts and are subdivided into...
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Clinical Behavior and Molecular Insights of Secretory Carcinoma of Salivary Glands, a Single Center Experience
Objective: the study aimed to characterize the novel entity referred to as secretory carcinoma of the salivary glands. Methods: we comprehensively...
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Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry
BackgroundOncocytoid salivary tumors include several entities such as oncocytoma, Warthin tumor, secretory carcinoma (SC), salivary duct carcinoma...
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Complete response to alectinib in ALK-fusion metastatic salivary ductal carcinoma
The advent of next-generation sequencing (NGS) has allowed for the identification of novel therapeutic targets for patients with uncommon cancers. It...
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Salivary gland secretory carcinoma presenting as a cervical soft tissue mass: a case report
BackgroundSecretory carcinoma (SC) has been described as a distinct salivary gland tumor in the fourth edition of the World Health Organization (WHO)...
