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Intoxication due to Δ9-tetrahydrocannabinol is characterized by disrupted prefrontal cortex activity
Neural states of impairment from intoxicating substances, including cannabis, are poorly understood. Cannabinoid 1 receptors, the main target of...
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Single-cell RNA-seq reveals the role of YAP1 in prefrontal cortex microglia in depression
BackgroundDepression is a complex mood disorder whose pathogenesis involves multiple cell types and molecular pathways. The prefrontal cortex, as a...
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Food stimuli decrease activation in regions of the prefrontal cortex related to executive function: an fNIRS study
PurposeOverweight/obese individuals show impairments in executive functions such as inhibitory control. However, the neural mechanisms underlying...
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Social experience in adolescence shapes prefrontal cortex structure and function in adulthood
During adolescence, the prefrontal cortex (PFC) undergoes dramatic reorganization. PFC development is profoundly influenced by the social...
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A zinc finger transcription factor enables social behaviors while controlling transposable elements and immune response in prefrontal cortex
The neurobiological origins of social behaviors are incompletely understood. Here we utilized synthetic biology approaches to reprogram the function...
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Perturbed iron biology in the prefrontal cortex of people with schizophrenia
Despite loss of grey matter volume and emergence of distinct cognitive deficits in young adults diagnosed with schizophrenia, current treatments for...
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Alteration of prefrontal cortex and its associations with emotional and cognitive dysfunctions in adolescent borderline personality disorder
The neurobiological mechanism of borderline personality disorder (BPD) in adolescents remains unclear. The study aimed to assess the alterations in...
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Functional connectivity between the amygdala and prefrontal cortex underlies processing of emotion ambiguity
Processing facial expressions of emotion draws on a distributed brain network. In particular, judging ambiguous facial emotions involves coordination...
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Effects of acute stress and depression on functional connectivity between prefrontal cortex and the amygdala
Stress is known to be a significant risk factor for the development of Major Depressive Disorder (MDD), yet the neural mechanisms that underlie this...
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Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex
Cognitive impairment is a core feature of schizophrenia, which is aggravated by antipsychotics-induced metabolic disturbance and lacks effective...
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Proteomic analysis of gene expression in the prefrontal cortex in infant rhesus macaques after multiple sevoflurane exposures
PurposeRepeated exposure of infant rhesus macaques to sevoflurane induces neurotoxicity and is associated with neurocognitive impairment in later...
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Prefrontal cortex astroglia modulate anhedonia-like behavior
Reductions of astroglia expressing glial fibrillary acidic protein (GFAP) are consistently found in the prefrontal cortex (PFC) of patients with...
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Effect of transcranial direct current stimulation with concurrent cognitive performance targeting posterior parietal cortex vs prefrontal cortex on working memory in schizophrenia: a randomized clinical trial
Working memory deficits are linked to irregularities in the dorsolateral prefrontal cortex (DLPFC) and the posterior parietal cortex (PPC) in...
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Xanomeline restores endogenous nicotinic acetylcholine receptor signaling in mouse prefrontal cortex
Cholinergic synapses in prefrontal cortex are vital for attention, but this modulatory system undergoes substantial pre- and post-synaptic...
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Fetal cannabidiol (CBD) exposure alters thermal pain sensitivity, problem-solving, and prefrontal cortex excitability
Thousands of people suffer from nausea with pregnancy each year. Nausea can be alleviated with cannabidiol (CBD), a primary component of cannabis...
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Pharmacogenetic activation of parvalbumin interneurons in the prefrontal cortex rescues cognitive deficits induced by adolescent MK801 administration
The cognitive symptoms of schizophrenia (SZ) present a significant clinical burden. They are treatment resistant and are the primary predictor of...
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A prefrontal cortex alpha/delta switch controls the transition from positive to negative affective states
Positive and negative emotional states in rats can be studied by investigating ultrasonic vocalizations (USVs). Positive affect in rats is indexed by...
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Astrocytes modulate cerebral blood flow and neuronal response to cocaine in prefrontal cortex
Cocaine affects both cerebral blood vessels and neuronal activity in brain. Cocaine can also disrupt astrocytes, which modulate neurovascular...
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The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions
Recent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear....
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Early-life prefrontal cortex inhibition and early-life stress lead to long-lasting behavioral, transcriptional, and physiological impairments
Early-life stress has been linked to multiple neurodevelopmental and neuropsychiatric deficits. Our previous studies have linked maternal...
