Search
Search Results
-
RNA modification-mediated mRNA translation regulation in liver cancer: mechanisms and clinical perspectives
Malignant liver cancer is characterized by rapid tumour progression and a high mortality rate, whereas the molecular mechanisms underlying liver...
-
Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies
Hematologic malignancies are one of the most common cancers, and the incidence has been rising in recent decades. The clinical and molecular features...
-
Research Progress in Function and Regulation of E3 Ubiquitin Ligase SMURF1
Smad ubiquitylation regulatory factor 1 (Smurf1) is an important homologous member of E6-AP C-terminus type E3 ubiquitin ligase. Initially, Smurf1...
-
Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis
Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action of various physical, chemical and...
-
Bone marrow mesenchymal stem cell-derived exosomal microRNA-382 promotes osteogenesis in osteoblast via regulation of SLIT2
BackgroundOsteoporosis (OP) is a systemic skeletal disorder with increased bone fragility. Human bone marrow mesenchymal stem cells (hBMSCs) have...
-
N6-methyladenosine methyltransferases: functions, regulation, and clinical potential
N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and...
-
Aging impairs the osteocytic regulation of collagen integrity and bone quality
Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular mechanisms that establish and maintain bone quality,...
-
Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis
Osteoarthritis (OA) is a common chronic disabling disease that affects hundreds of millions of people around the world. The most important...
-
Regulation of VEGF-A expression and VEGF-A-targeted therapy in malignant tumors
Vascular endothelial growth factor A (VEGF-A), a highly conserved dimeric glycoprotein, is a key regulatory gene and a marker molecule of...
-
MiR-25 overexpression inhibits titanium particle-induced osteoclast differentiation via down-regulation of mitochondrial calcium uniporter in vitro
BackgroundMitochondrial calcium uniporter (MCU) is an important ion channel regulating calcium transport across the mitochondrial membrane. Calcium...
-
The crucial role of LncRNA MIR210HG involved in the regulation of human cancer and other disease
Long noncoding RNAs (lncRNAs) have evoked considerable interest in recent years due to their critical functions in the regulation of disease...
-
Regulation of Src tumor activity by its N-terminal intrinsically disordered region
The membrane-anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src...
-
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA methylation, chromatin...
-
Exploring the enigma: history, present, and future of long non-coding RNAs in cancer
Long noncoding RNAs (lncRNAs), which are more than 200 nucleotides in length and do not encode proteins, play crucial roles in governing gene...
-
Efficacy of Bioactive Compounds in the Regulation of Metabolism and Pathophysiology in Cardiovascular Diseases
Purpose of ReviewAn imbalance in reactive oxygen species (ROS) homeostasis can wreak damage to metabolic and physiological processes which can...
-
Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease that affects an estimated 300 million people worldwide, but...
-
-
DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression
Type 1 insulin-like growth factor receptor (IGF1R) plays an important role in cancer, however, posttranscriptional regulation such as N 6 -methyladenosi...
-
BHLHE41 inhibits bladder cancer progression via regulation of PYCR1 stability and thus inactivating PI3K/AKT signaling pathway
BackgroundThe basic helix-loop-helix family member e41 (BHLHE41) is frequently dysregulated in tumors and plays a crucial role in malignant...
-
The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis
Despite recent advances in therapeutic approaches, patients with MLL-rearranged leukemia still have poor outcomes. Here, we find that the RNA-binding...
