Search
Search Results
-
Effects of pasteurization on osteopontin concentrations in human breastmilk
BackgroundOsteopontin (OPN) is an important breastmilk protein involved in infant intestinal, immunological, and brain development. However, little...
-
Osteopontin: A Novel Therapeutic Target for Respiratory Diseases
Osteopontin (OPN) is a multifunctional phosphorylated protein that is involved in physiological and pathological events. Emerging evidence suggests...
-
Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritis
BackgroundAnti-citrullinated protein/peptide antibodies (ACPAs) are present in patients at onset and have important pathogenic roles during the...
-
Osteopontin promotes infarct repair
Understanding how macrophages promote myocardial repair can help create new therapies for infarct repair. We aimed to determine what mechanisms...
-
Osteopontin is a prognostic circulating biomarker in patients with neuroendocrine neoplasms
PurposeOsteopontin (OPN), also called secreted phosphoprotein 1 (SPP1) is a matricellular glycoprotein whose expression is elevated in various types...
-
Circulating Osteopontin Predicts Clinical and Radiological Response in First-Line Treatment of Advanced Non-Small Cell Lung Cancer
PurposePembrolizumab-based regimens are conditioned by the expression of PD-L1, but durable response rate is limited by innate and acquired...
-
Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood–brain barrier in acute ischemic stroke
Blood–brain barrier (BBB) dysfunction, characterized by degradation of BBB junctional proteins and increased permeability, is a crucial...
-
A case of neurodegenerative Langerhans cell histiocytosis exhibiting high osteopontin in cerebrospinal fluid without specific radiological abnormalities
Neurodegenerative Langerhans cell histiocytosis (ND-LCH) manifests several years after onset of LCH, with progressive neurological symptoms and...
-
Serum osteopontin predicts the response to atezolizumab plus bevacizumab in patients with hepatocellular carcinoma
BackgroundCombination therapy with anti-programmed death-ligand 1 and anti-vascular endothelial growth factor (VEGF) antibodies has become the...
-
IER2-induced senescence drives melanoma invasion through osteopontin
Expression of the immediate-early response gene IER2 has been associated with the progression of several types of cancer, but its functional role is...
-
Osteopontin, osteoprotegerin and musculoskeletal ultrasound findings in first-degree relatives of rheumatoid arthritis: potential markers of preclinical disease
BackgroundFirst-degree relatives (FDRs) of rheumatoid arthritis (RA) patients are known to have increased risk of develo** the disease. The...
-
Inhibition of ERK1/2 signaling prevents bone marrow fibrosis by reducing osteopontin plasma levels in a myelofibrosis mouse model
Clonal myeloproliferation and development of bone marrow (BM) fibrosis are the major pathogenetic events in myelofibrosis (MF). The identification of...
-
The utility of serum osteopontin levels for predicting postoperative complications after colorectal cancer surgery
Background/AimOsteopontin (OPN) is a secretory glycoprotein, which is expressed not only in osteoblasts, but immune cells including macrophages and...
-
Reliability, stability during long-term storage, and intra-individual variation of circulating levels of osteopontin, osteoprotegerin, vascular endothelial growth factor-A, and interleukin-17A
BackgroundStudies in many populations have reported associations between circulating cytokine levels and various physiological or pathological...
-
Association of serum levels of osteopontin and osteoprotegerin with adverse outcomes after endovascular revascularisation in peripheral artery disease
BackgroundOsteoprotegerin (OPG) and osteopontin (OPN) are vascular calcification inhibitors with a known role in the atherosclerotic and inflammatory...
-
Alterations in the balance of sex hormones may affect rat prostatic inflammation and fibrosis, and osteopontin might be involved in this process
ObjectiveThis study aimed to investigate the effects of sex hormone imbalance on rat prostatic inflammation and fibrosis and identify the key...
-
Osteopontin promotes tumor growth and metastasis and GPX4-mediated anti-lipid peroxidation in triple-negative breast cancer by activating the PI3k/Akt/mTOR pathway
PurposeTriple-negative breast cancer (TNBC) features high aggressiveness, metastasis rate, drug resistance as well as poor prognosis. Osteopontin...
-
Osteopontin‐induced lncRNA HOTAIR expression is involved in osteoarthritis by regulating cell proliferation
BackgroundOsteopontin plays critical roles in osteoarthritis (OA) by regulating the functions of osteoclasts. It is known that osteopontin can induce...
-
Plasmatic osteopontin and vascular access dysfunction in hemodialysis patients: a cross-sectional, case–control study (The OSMOSIS Study)
Background and aimsDespite close follow-up of patients with native arteriovenous fistulas (AVFs), up to 10% experience thrombosis each year. The...
