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Simplification of Complex Insulin Regimens with IdegLira in People with Type 2 Diabetes: Literature Review and Clinical Recommendations
IntroductionThis study developed a simple algorithm based on clinical results described in medical literature and which allows one to simplify...
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One hundred years of insulin therapy
At the time of its first clinical application 100 years ago, insulin was presented as the cure for people with diabetes mellitus. That transpired to...
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Expert Opinion on the Therapeutic Use of the Fixed-Ratio Combination of Insulin Glargine 100 U/mL and Lixisenatide: a Central/Eastern European Perspective
The fixed-ratio combination (FRC) of a basal insulin and a GLP-1 receptor agonist (GLP-1 RA) has proven to be an effective therapeutic approach....
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Saxagliptin/Dapagliflozin: A Review in Type 2 Diabetes Mellitus
Saxagliptin/dapagliflozin fixed-dose combination tablets (Qtern ® ) are indicated in the EU for the improvement of glycaemic control in adults with...
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Dietary saturated fat/cholesterol, but not unsaturated fat or starch, induces C-reactive protein associated early atherosclerosis and ectopic fat deposition in diabetic pigs
BackgroundDiabetes is thought to accelerate cardiovascular disease depending on the type of diet. This study in diabetic subjects was performed to...
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Fixed Combination Trandolapril/Verapamil Sustained-Release
AbstractIn well designed studies in patients with mild to moderate hypertension, combinations of the sustained-release (SR) formulation of the...
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Alteration of the counterregulatory hormones in the conscious rat after protein-energy restriction
We have recently reported that in rats submitted to protein-energy restriction early in life, an increased insulin efficiency upon the whole-body...
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Pulsatile intravenous insulin replacement in streptozotocin-diabetic rats is more efficient than continuous delivery: effects on glycaemic control, insulin-mediated glucose metabolism and lipolysis
Short-term exposure of tissues to pulses of insulin generally leads to an enhancement of insulin action. We have investigated the possible beneficial...
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Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy
Postprandial glucagon-like peptide-1 (GLP-1), pancreatic glucagon, and insulin were measured in 27 tumor-free patients 43 months (median) after total...
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Effect of nicotinamide treatment on the residual insulin secretion in Type 1 (insulin-dependent) diabetic patients
In vivo and in vitro experiments have shown that nicotinamide enhances the regeneration of rat B cells. Nicotinamide has been administered to human...
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Advances in insulin therapy for insulin-dependent diabetic children
During the last two decades new forms of insulin and a better understanding of the physiological insulin secretion profile have led to great changes...
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Cholinergic stimulation of insulin release from cloned B-cell lines HIT-T15 and RINm5F
Acetylcholine stimulated the release of insulin from cultured HIT-T15 and RINm5F cells in the absence of glucose confirming that the insulin response...
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Effect of storage temperature of insulin on pharmacokinetics and pharmacodynamics of insulin mixtures injected subcutaneously in subjects with Type 1 (insulin-dependent) diabetes mellitus
These studies were undertaken to assess the influence of storage temperature of insulin vials on pharmacokinetics and pharmacodynamics of a mixture...
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Insulin autoantibodies are associated with islet cell antibodies; their relation to insulin antibodies and B-cell function in diabetic children
Blood was drawn from 74 children, 3–16 years old, at diagnosis of Type 1 (insulin-dependent) diabetes and before the first insulin injection. Insulin...