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Concomitant use of monoamine oxidase inhibitor and tyrosine in parenteral nutrition
Monoamine oxidase inhibitors (MAOIs) prevent the breakdown of tyramine in the body, and can cause a sudden increase in blood pressure with...
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Targeting monoamine oxidase A: a strategy for inhibiting tumor growth with both immune checkpoint inhibitors and immune modulators
Monoamine oxidase A (MAOA) is a membrane-bound mitochondrial enzyme present in almost all vertebrate tissues that catalyzes the degradation of...
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Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson’s disease
Parkinson’s disease is characterized by its distinct pathological features; loss of dopamine neurons in the substantia nigra pars compacta and...
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Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo
Variants within the monoamine oxidase A (MAO-A, MAOA ) and tryptophan hydroxylase 2 (TPH2 ) genes, the main enzymes in cerebral serotonin (5-HT)...
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High monoamine oxidase a expression predicts poor prognosis for prostate cancer patients
BackgroundMonoamine oxidase A (MAOA) is a mitochondrial enzyme that is involved in prostate tumorigenesis and cancer metastasis. The predictive power...
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Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer’s disease and related dementias
Reactive astrogliosis accompanies the two neuropathological hallmarks of Alzheimer’s disease (AD)—Aβ plaques and neurofibrillary tangles—and...
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Monoamine oxidase A-dependent ROS formation modulates human cardiomyocyte differentiation through AKT and WNT activation
During embryonic development, cardiomyocytes undergo differentiation and maturation, processes that are tightly regulated by tissue-specific...
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Prescription Pattern of Monoamine Oxidase B Inhibitors Combined with Levodopa: A Retrospective Observational Analysis of Italian Healthcare Administrative Databases
BackgroundParkinson’s disease is still incurable, and several factors are considered when defining pharmacological therapy.
Objective ... -
Monoamine oxidase binding not expected to significantly affect [18F]flortaucipir PET interpretation
Purpose[ 18 F]-labeled positron emission tomography (PET) radioligands permit in vivo assessment of Alzheimer’s disease biomarkers, including...
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Age-related increase of monoamine oxidase B in amyloid-negative cognitively unimpaired elderly subjects
ObjectiveMonoamine oxidase B (MAO-B) is highly abundant in reactive astrocytes and upregulated in neuroinflammatory processes. However, the...
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Effects of monotherapy with a monoamine oxidase B inhibitor on motor symptoms in Parkinson’s disease are dependent on frontal function
BackgroundMonotherapy with monoamine oxidase B (MAO-B) inhibitors enhances the level of endogenous dopamine in treatment for Parkinson’s disease (PD)...
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Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function
We have recently identified a pool of intracellular β 1 adrenergic receptors (β 1 ARs) at the sarcoplasmic reticulum (SR) crucial for cardiac function....
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Site-activated multi target iron chelators with acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitory activities for Alzheimer’s disease therapy
The first class of site-activated chelators with dual inhibition of acetyl-cholinesterase (AChE) and monoamine oxidase (MAO), rationally designed for...
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Monoamine Oxidase Inhibitors (MAOIs) in Psychiatric Practice: How to Use them Safely and Effectively
Monoamine oxidase inhibitors (MAOIs) were among the first licensed pharmacological treatments for patients with depression but over time have fallen...
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Associations of age, sex, sexual abuse, and genotype with monoamine oxidase a gene methylation
Epigenome-wide studies report higher methylation among women than men with decreasing levels with age. Little is known about associations of sex and...
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The trace amine theory of spontaneous hypertension as induced by classic monoamine oxidase inhibitors
The classic monoamine oxidase inhibitors (MAOIs) tranylcypromine (TCP) and phenelzine (PLZ) are powerful antidepressants that come with an equally...
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Recent advances on the role of monoamine oxidases in cardiac pathophysiology
Numerous physiological and pathological roles have been attributed to the formation of mitochondrial reactive oxygen species (ROS). However, the...
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Association between monoamine oxidase A promoter polymorphism and the risk of sudden infant death syndrome: a meta-analysis
IntroductionThe etiology of sudden infant death syndrome (SIDS) remains an unsolved problem. The aim of this meta-analysis is to investigate the...
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Common network effect-patterns after monoamine reuptake inhibition in dissociated hippocampus cultures
The pharmacological treatment of major depressive disorder with currently available antidepressant drugs is still unsatisfying as response to...