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Dynamic evolution and mechanism of myocardial glucose metabolism in different functional phenotypes of diabetic cardiomyopathy — a study based on 18 F-FDG microPET myocardial metabolic imaging
PurposeTo use 18 F-FDG microPET dynamic imaging to preliminarily identify the changes of myocardial glucose metabolism corresponding to different...
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Longitudinal evaluation of five nasopharyngeal carcinoma animal models on the microPET/MR platform
PurposeWe longitudinally evaluated the tumour growth and metabolic activity of three nasopharyngeal carcinoma (NPC) cell line models (C666-1, C17 and...
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MicroPET imaging of bacterial infection with nitroreductase-specific responsive 18F-labelled nitrogen mustard analogues
PurposeBacterial infection and antibiotic resistance are serious threats to human health. This study aimed to develop two novel radiotracers, 18 F-NTR...
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Preclinical evaluation of [18F]SYN1 and [18F]SYN2, novel radiotracers for PET myocardial perfusion imaging
BackgroundPositron emission tomography (PET) is now an established diagnostic method for myocardial perfusion imaging (MPI) in coronary artery...
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Development of a novel 18F-labeled small molecule probe for PET imaging of mesenchymal epithelial transition receptor expression
AbstractThe mesenchymal epithelial transition factor (c-Met) is frequently overexpressed in numerous cancers and has served as a validated anticancer...
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Development and application of a fully automatic multi-function cassette module Mortenon M1 for radiopharmaceutical synthesis
IntroductionFunctions of existing automatic module systems for synthesis of radiopharmaceuticals mainly focus on the radiolabeling of small...
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Influence of the use of autogenous bone particles to close the access window after maxillary sinus floor augmentation: a micro‐computed tomography and positron emission tomography study in rabbits
AimThe purpose of this study was to evaluate using microCT and positron emission tomography (PET) analysis, the influence on bone healing of the...
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Synthesis, preclinical evaluation and pilot clinical translation of [68Ga]Ga-PMD22, a novel nanobody PET probe targeting CLDN18.2 of gastrointestinal cancer
PurposeClaudin18.2 (CLDN18.2) is a novel target for diagnosis and therapy of gastrointestinal cancer. This study aimed to evaluate the safety and...
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Ultrasensitive detection of uveal melanoma using [18F]AlF-NOTA-PRGD2 PET imaging
BackgroundUveal melanoma (UM) is the most common primary intraocular tumor in adults, and early detection is critical to improve the clinical outcome...
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Effect of Cyclosporin H on ischemic injury and neutrophil infiltration in cerebral infarct model of rats via PET imaging
BackgroundBrain ischemia–reperfusion injury is a complex process, and neuroinflammation is an important secondary contributing pathological event....
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Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model
BackgroundMicrotubules (MTs) are critical for cell structure, function, and survival. MT instability may contribute to Alzheimer’s disease (AD)...
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Comparative in vivo biodistribution of cells labelled with [89Zr]Zr-(oxinate)4 or [89Zr]Zr-DFO-NCS using PET
BackgroundIn vivo monitoring of cell biodistribution using positron emission tomography (PET) provides a quantitative non-invasive method to further...
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First-in-human validation of enzymolysis clearance strategy for decreasing renal radioactivity using modified [68Ga]Ga-HER2 Affibody
PurposeEnzymolysis clearance strategy, characterized by releasing the non-reabsorbable radioactive fragment under the specific cleavage of enzymes,...
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Radiosynthesis and Evaluation of a C-11 Radiotracer for Transient Receptor Potential Canonical 5 in the Brain
PurposeTRPC5 belongs to the mammalian superfamily of transient receptor potential (TRP) Ca 2+ -permeable cationic channels and it has been implicated...
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Evaluation of novel anti-CEACAM6 antibody-based conjugates for radioimmunotheranostics of pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a highly malignant solid tumor that lacks early diagnostic methods. Recently, targeted...
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In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS
BackgroundPerturbed functional coupling between the metabotropic glutamate receptor-5 (mGluR5) and N-methyl- d -aspartate (NMDA) receptor-mediated...
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Synthesis, preclinical, and initial clinical evaluation of integrin αVβ3 and gastrin-releasing peptide receptor (GRPR) dual-targeting radiotracer [68Ga]Ga-RGD-RM26-03
AbstractIntegrin receptor α v β 3 and gastrin-releasing peptide receptor (GRPR) expression of tumors could be detected using PET imaging with...
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Preliminary efficacy of [90Y]DOTA-biotin-avidin radiotherapy against non-muscle invasive bladder cancer
PurposeBladder cancer represents 3% of all new cancer diagnoses per year. We propose intravesical radionuclide therapy using the β-emitter 90 Y...
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Homodimeric peptide radiotracer [68Ga]Ga-NOTA-(TMVP1)2 for VEGFR-3 imaging of cervical cancer patients
PurposeVascular endothelial growth factor receptor 3 (VEGFR-3) plays a critical role in tumor lymphangiogenesis and metastasis, holding promise as a...
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A comparison of [18F]AlF- and 68Ga-labeled dual targeting heterodimer FAPI-RGD in malignant tumor: preclinical evaluation and pilot clinical PET/CT imaging
AbstractDue to the heterogeneity of tumors, strategies to improve the effectiveness of dual-targeting tracers in tumor diagnostics have been...
