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MiR-135a-5p suppresses trophoblast proliferative, migratory, invasive, and angiogenic activity in the context of unexplained spontaneous abortion
BackgroundSpontaneous abortions (SA) is amongst the most common complications associated with pregnancy in humans, and the underlying causes cannot...
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Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine
Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and...
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Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis
Accumulating evidences have suggested that extracellular vesicles (EVs) are crucial players in the pathogenesis of ischemic brain injury. This study...
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LncRNA differentiation antagonizing non-protein coding RNA promotes proliferation and invasion through regulating miR-135a/NLRP37 axis in pancreatic cancer
Background It is well-known that long-chain non-coding RNA (LncRNA) plays an important role in the development of tumor. DANCR, which is one crucial...
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Long Non-coding RNA Involved in the Pathophysiology of Atrial Fibrillation
BackgroundAtrial fibrillation (AF) is a prevalent and chronic cardiovascular disorder associated with various pathophysiological alterations,...
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Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems
Diabetes mellitus, a group of metabolic disorders characterized by high levels of blood glucose caused by insulin defect or impairment, is a major...
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The role and mechanism of epigenetics in anticancer drug-induced cardiotoxicity
Cardiovascular disease is the main factor contributing to the global burden of diseases, and the cardiotoxicity caused by anticancer drugs is an...
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Epigenetic Mechanisms Involved in Inflammaging-Associated Hypertension
Purpose of ReviewThis review summarizes the involvement of inflammaging in vascular damage with focus on the epigenetic mechanisms by which...
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Recent miRNA Research in Asthma
Purpose of ReviewThe study of microRNA in asthma has revealed a vibrant new level of gene regulation underlying asthma pathology. Several miRNAs have...
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Clinical applications of stem cell-derived exosomes
Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it...
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CCDC50, an essential driver involved in tumorigenesis, is a potential severity marker of diffuse large B cell lymphoma
Diffuse Large B Cell Lymphoma (DLBCL) is the most common form of blood cancer. Among the subtypes, the activated B-cell (ABC) subtype is typically...
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Lymphangiogenesis in gastric cancer: function and mechanism
Increased lymphangiogenesis and lymph node (LN) metastasis are thought to be important steps in cancer metastasis, and are associated with patient's...
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Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity,...
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Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in which the airways narrow or collapse during sleep, causing...
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Changes in RNA expression levels during antidepressant treatment: a systematic review
More than a third of patients treated with antidepressants experience treatment resistance. Furthermore, molecular pathways involved in...
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The Regulatory Role of miRNAs in Ethanol-induced TLR4 Activation and Neuroinflammation
Purpose of ReviewAlcohol is a neurotoxic compound and its abuse can induce brain damage and neurodegeneration. Evidence from the last decade...
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The Long Non-coding Road to Atherosclerosis
Purpose of ReviewTo summarize recent insights into long non-coding RNAs (lncRNAs) involved in atherosclerosis. Because atherosclerosis is the main...
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Identification of hub genes related to the progression of type 1 diabetes by computational analysis
BackgroundType 1 diabetes (T1D) is a serious threat to childhood life and has fairly complicated pathogenesis. Profound attempts have been made to...
