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Transcriptional regulation of NRF1 on metabotropic glutamate receptors in a neonatal hypoxic‑ischemic encephalopathy rat model
BackgroundNeonatal hypoxic-ischemic encephalopathy (HIE) is a kind of brain injury that causes severe neurological disorders in newborns....
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Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects
Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu 2 R and mGlu 3 R) in brains of schizophrenia patients...
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Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density
Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in stress and reward processing, both crucially impaired in...
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Diet-induced deficits in goal-directed control are rescued by agonism of group II metabotropic glutamate receptors in the dorsomedial striatum
Many overweight or obese people struggle to sustain the behavioural changes necessary to achieve and maintain weight loss. In rodents, obesogenic...
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Genetics of glutamate and its receptors in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by deficits in social interaction skills, impaired communication, and...
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Perineuronal nets are under the control of type-5 metabotropic glutamate receptors in the develo** somatosensory cortex
mGlu5 metabotropic glutamate receptors are highly functional in the early postnatal life, and regulate developmental plasticity of...
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Glutamate receptors in brain development
Brain development encompasses a number of processes including synaptogenesis, migration and synaptic plasticity. These activities are regulated by...
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Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu3) impairs postsynaptic plasticity and modulates affective behaviors
Clinical and translational studies suggest that prefrontal cortex (PFC) dysregulation is a hallmark feature of several affective disorders. Thus,...
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Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinence
Chronic alcohol use has important effects on the glutamate system. The metabotropic glutamate 5 (mGlu5) receptor has shown promise in preclinical...
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Parvalbumin interneuron mGlu5 receptors govern sex differences in prefrontal cortex physiology and binge drinking
Despite established sex differences in the prevalence and presentation of psychiatric disorders, little is known about the cellular and synaptic...
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Multiple serum anti-glutamate receptor antibody levels in clozapine-treated/naïve patients with treatment-resistant schizophrenia
BackgroundGlutamatergic function abnormalities have been implicated in the etiology of treatment-resistant schizophrenia (TRS), and the efficacy of...
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Loss of mGlu5 receptors in somatostatin-expressing neurons alters negative emotional states
Subtype 5 metabotropic glutamate receptors (mGlu 5 ) are known to play an important role in regulating cognitive, social and valence systems. However,...
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Glutamate imbalance in key structure of the default mode network in adults with attention-deficit/hyperactivity disorder
The default mode network (DMN) is atypically active in patients with ADHD, likely contributing to the inattention patterns observed in patients with...
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Restoring glutamate receptosome dynamics at synapses rescues autism-like deficits in Shank3-deficient mice
Shank3 monogenic mutations lead to autism spectrum disorders (ASD). Shank3 is part of the glutamate receptosome that physically links ionotropic NMDA...
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Gene variations of glutamate metabolism pathway and epilepsy
BackgroundEpilepsy is a paroxysmal disorder of the brain, caused by an imbalance of neuronal excitation and inhibition. Glutamate is the most...
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Study of influence of the glutamatergic concentration of [18F]FPEB binding to metabotropic glutamate receptor subtype 5 with N-acetylcysteine challenge in rats and SRM/PET study in human healthy volunteers
Altered glutamate signaling is thought to be involved in a myriad of psychiatric disorders. Positron emission tomography (PET) imaging with [ 18 F]FPEB...
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Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia
Dopamine (DA) and glutamate neurotransmission are strongly implicated in schizophrenia pathophysiology. While most studies focus on contributions of...
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Role of ATP in migraine mechanisms: focus on P2X3 receptors
Migraine is a major health burden worldwide with complex pathophysiology and multifarious underlying mechanisms. One poorly understood issue concerns...
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Glutamatergic Agents for the Treatment of Cocaine Use Disorder
Purpose of ReviewDisruptions in glutamate hemostasis have been implicated in cocaine use disorder (CUD). This manuscript reviews novel agents that...
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Glutamate and GABAA receptor crosstalk mediates homeostatic regulation of neuronal excitation in the mammalian brain
Maintaining a proper balance between the glutamate receptor-mediated neuronal excitation and the A type of GABA receptor (GABA A R) mediated inhibition...
