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mGlu2/3 receptor antagonists for depression: overview of underlying mechanisms and clinical development
Triggered by the ground-breaking finding that ketamine exerts robust and rapid-acting antidepressant effects in patients with treatment-resistant...
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Effects of the mGlu2/3 receptor agonist LY379268 on two models of disturbed auditory evoked brain oscillations in mice
Cognitive impairment is a core feature of schizophrenia and is poorly addressed by currently available medication. This is partly because the...
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Rapastinel alleviates the neurotoxic effect induced by NMDA receptor blockade in the early postnatal mouse brain
Rapastinel is a novel psychoactive substance that acts as an N-methyl-D-aspartate-receptor (NMDAR) agonist and triggers antidepressant- and...
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Pre- and postsynaptic signatures in the prelimbic cortex associated with “alcohol use disorder” in the rat
The transition to alcohol use disorder (AUD) involves persistent neuroadaptations in executive control functions primarily regulated by the medial...
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Trace Amine-Associated Receptor 1 as a Target for the Development of New Antipsychotics: Current Status of Research and Future Directions
Schizophrenia is a mental illness associated with an array of symptoms that often result in disability. The primary treatments for schizophrenia are...
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Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics
Psychedelics, also known as classical hallucinogens, have been investigated for decades due to their potential therapeutic effects in the treatment...
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The neuropsychopharmacology of acetyl-L-carnitine (LAC): basic, translational and therapeutic implications
Mitochondrial metabolism can contribute to nuclear histone acetylation among other epigenetic mechanisms. A central aspect of this signaling pathway...
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Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression
Therapeutic deficiencies with monoaminergic antidepressants invites the need to identify and develop novel rapid-acting antidepressants. Hitherto,...
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Assessment of Innovative Pharmacological Targets in Schizophrenia
Purpose of reviewSchizophrenia is a disorder with an approximate prevalence of 1% associated with great impairments in daily life functioning and...
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The mGlu2/3 antagonist LY-341,495 reverses the anti-dyskinetic and anti-psychotic effects of the mGlu2 activators LY-487,379 and LY-354,740 in the MPTP-lesioned marmoset
We have recently shown that activation of metabotropic glutamate 2 (mGlu 2 ) receptors through positive allosteric modulation and orthosteric...
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Operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2
Dorsal striatal manipulations including stimulation of dopamine release and activation of medium spiny neurons (MSNs) are sufficient to drive...
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G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the...
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Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status
The efficacy of standard antidepressants is limited for many patients with mood disorders such as major depressive disorder (MDD) and bipolar...
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Preventing incubation of drug craving to treat drug relapse: from bench to bedside
In 1986, Gawin and Kleber reported a progressive increase in cue-induced drug craving in individuals with cocaine use disorders during prolonged...
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Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia
According to the adenosine hypothesis of schizophrenia, the classically associated hyperdopaminergic state may be secondary to a loss of function of...
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Targeting Serotonin 5-HT2A Receptors to Better Treat Schizophrenia: Rationale and Current Approaches
Schizophrenia is a major mental illness associated with profound disability. Current treatments for schizophrenia (antipsychotics) all have a similar...
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Perinatal THC exposure via lactation induces lasting alterations to social behavior and prefrontal cortex function in rats at adulthood
Cannabis is the world’s most widely abused illicit drug and consumption amongst women during and surrounding the period of pregnancy is increasing....
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The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder
Purpose of the reviewThe abuse of opioids induces many terrible problems in human health and social stability. For opioid-dependent individuals,...
