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Lymphangiogenesis in gastric cancer: function and mechanism
Increased lymphangiogenesis and lymph node (LN) metastasis are thought to be important steps in cancer metastasis, and are associated with patient's...
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Anti-lymphangiogenesis for boosting drug accumulation in tumors
The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant...
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Dual FGFR and VEGFR inhibition synergistically restrain hexokinase 2-dependent lymphangiogenesis and immune escape in intrahepatic cholangiocarcinoma
BackgroundTherapies for cholangiocarcinoma are largely limited and ineffective. Herein, we examined the role of the FGF and VEGF pathways in...
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The natural FGF-trap long pentraxin 3 inhibits lymphangiogenesis and lymphatic dissemination
The lymphatic vascular system represents a major route for dissemination of several solid tumors, including melanoma. Even though the members of the...
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Long noncoding RNA CLAN promotes lymphangiogenesis in the colorectal carcinoma
Metastasis is the main cause of colorectal cancer (CRC)-related death and lymph node plays a vital role in this process. Long noncoding RNAs...
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Anthracycline chemicals with anthracyclinone structure exert antitumor effects by inhibiting angiogenesis and lymphangiogenesis in a xenografted gastric tumor model
BackgroundIt is vital to screen or develop alternative therapeutic drugs with higher curative characteristics and fewer side effects for the clinical...
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The role of lymphangiogenesis in cardiovascular diseases and heart transplantation
Cardiac lymphangiogenesis plays an important physiological role in the regulation of interstitial fluid homeostasis, inflammatory, and immune...
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Intratumoral PDGFB gene predominantly expressed in endothelial cells is associated with angiogenesis and lymphangiogenesis, but not with metastasis in breast cancer
PurposePlatelet-derived growth factor B (PDGFB) is known to play essential roles in angiogenesis and lymphangiogenesis during development, and tumor...
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Evaluation of Lymphangiogenesis in Breast Carcinomas Using D2-40 Immunostain
Materials and MethodsSixty-five cases of carcinoma breast were studied. Various histological parameters were evaluated and subjected to...
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SERPINE2 is an oral cancer-promoting factor that induces angiogenesis and lymphangiogenesis
BackgroundLEM domain containing 1 (LEMD1) is a novel factor involved in the development of oral squamous cell carcinoma (OSCC). We previously...
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Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets
Lymphatic vessels, comprising the secondary circulatory system in human body, play a multifaceted role in maintaining homeostasis among various...
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The role of lymphatic vessels in corneal fluid homeostasis and wound healing
The cornea, essential for vision, is normally avascular, transparent, and immune-privileged. However, injuries or infections can break this...
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SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer
Lymph node (LN) metastasis is one of the predominant metastatic routes of non-small cell lung cancer (NSCLC) and is considered as a leading cause for...
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RAMP1 signaling in immune cells regulates inflammation-associated lymphangiogenesis
Calcitonin gene-related peptide (CGRP) regulates inflammation via signaling through receptor activity-modifying protein (RAMP) 1. Here, we...
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Toward Characterizing Lymphatic Vasculature in the Mammary Gland During Normal Development and Tumor-Associated Remodeling
Lymphatic vasculature has been shown to promote metastatic spread of breast cancer. Lymphatic vasculature, which is made up of larger collecting...
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Comparison of avascular lymph node fragment transplantation techniques to optimize lymphangiogenesis in the minipig model
BackgroundSecondary lymphoedema is a challenging pandemic. This condition may arise after oncologic resection of tumor-draining lymph nodes and/or...
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CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability
Lymph node (LN) metastasis is one of the most malignant clinical features in patients with cervical cancer (CCa). Understanding the mechanism of...
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Targeting angiogenesis and lymphangiogenesis in kidney disease
The kidney is permeated by a highly complex vascular system with glomerular and peritubular capillary networks that are essential for maintaining the...
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Inflammation, Lymphatics, and Cardiovascular Disease: Amplification by Chronic Kidney Disease
Purpose of ReviewKidney disease is a strong modulator of the composition and metabolism of the intestinal microbiome that produces toxins and...
