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Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology
The latest findings in iron metabolism and the newly uncovered process of ferroptosis have paved the way for new potential strategies in...
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Effective delivery of anti-PD-L1 siRNA with human heavy chain ferritin (HFn) in acute myeloid leukemia cell lines
Because of the high biocompatibility, self-assembly capability, and CD71-mediated endocytosis, using human heavy chain ferritin (HFn) as a...
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Novel mitochondria-targeting compounds selectively kill human leukemia cells
Acute myeloid leukemia (AML) is a heterogeneous group of aggressive hematological malignancies commonly associated with treatment resistance, high...
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A novel anticancer quinolone, (R)-WAC-224, has anti-leukemia activities against acute myeloid leukemia
Approximately 60%–80% of patients who achieve complete remission eventually relapse after conventional chemotherapy and have poor prognoses despite...
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Transgenic IDH2R172K and IDH2R140Q zebrafish models recapitulated features of human acute myeloid leukemia
Isocitrate dehydrogenase 2 ( IDH2 ) mutations occur in more than 15% of cytogenetically normal acute myeloid leukemia (CN-AML) but comparative studies...
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TIF1β activates leukemic transcriptional program in HSCs and promotes BCR::ABL1-induced myeloid leukemia
TIF1β/KAP1/TRIM28, a chromatin modulator, both represses and activates the transcription of genes in normal and malignant cells. Analyses of datasets...
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Evaluation of human T-cell leukemia virus in vitro diagnostics using plasma specimens collected in Japan
BackgroundIn vitro diagnostics (IVDs) for primary detection test/screening of human T-cell leukemia virus (HTLV) have recently been updated to...
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Low doses of IFN-γ maintain self-renewal of leukemia stem cells in acute myeloid leukemia
Conventional therapies for acute myeloid leukemia (AML) often fail to eliminate the disease-initiating leukemia stem cell (LSC) population, leading...
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Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression
TNF receptor associated factor 6 (TRAF6) is an E3 ubiquitin ligase that has been implicated in myeloid malignancies. Although altered TRAF6...
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Obesity and Leukemia: Biological Mechanisms, Perspectives, and Challenges
Purpose of ReviewTo examine the epidemiological data on obesity and leukemia; evaluate the effect of obesity on leukemia outcomes in childhood acute...
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t(1;4) translocation in a child with acute lymphoblastic leukemia: a case report
BackgroundAcute lymphoblastic leukemia is the most common childhood cancer, with an 80% frequency in children between 1 and 10 years old. The outcome...
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XPO1 inhibition displays anti-leukemia efficacy against DNMT3A-mutant acute myeloid leukemia via downregulating glutathione pathway
Acute myeloid leukemia (AML) patients with DNA methyltransferase 3A (DNMT3A) mutation display poor prognosis, and targeted therapy is not available...
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The landscape of RNA-chromatin interaction reveals small non-coding RNAs as essential mediators of leukemia maintenance
RNA constitutes a large fraction of chromatin. Spatial distribution and functional relevance of most of RNA-chromatin interactions remain unknown. We...
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Salvage hematopoietic stem cell transplantation for patients with higher leukemia burden in relapsed or refractory acute myeloid leukemia: a ten-year study
Patients with relapsed and refractory acute myeloid leukemia (R-R AML), especially those in non-remission (NR) have a poor prognosis after allogeneic...
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A complex interplay of intra- and extracellular factors regulates the outcome of fetal- and adult-derived MLL-rearranged leukemia
Infant and adult MLL1/KMT2A -rearranged (MLLr) leukemia represents a disease with a dismal prognosis. Here, we present a functional and proteomic...
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Metabolic dependencies of acute myeloid leukemia stem cells
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy primarily driven by an immature population of AML cells termed leukemia stem...
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Nanotechnology in leukemia: diagnosis, efficient-targeted drug delivery, and clinical trials
Leukemia is a group of malignant disorders which affect the blood and blood-forming tissues in the bone marrow, lymphatic system, and spleen. Many...
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Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia
The chromatin-associated AAA+ ATPases Tip48 and Tip49 are the core components of various complexes implicated in diverse nuclear events such as DNA...
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Research Progress on the Use of Metformin in Leukemia Treatment
Metformin is a first-line drug in the clinical treatment of type 2 diabetes. Its main molecular mechanism involves the activation of adenosine...
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Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency
GATA1 plays a critical role in differentiation, proliferation, and apoptosis during erythropoiesis. We developed a Gata1 knock-down allele ( Gata1.05 )...
