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Homocysteine and mitochondrial quality control in diabetic retinopathy
BackgroundDiabetic retinopathy is a progressive disease, and one of the key metabolic abnormalities in the pathogenesis of diabetic retinopathy,...
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Homocysteine levels correlate with AVSS-RigiScan test parameters in men with erectile dysfunction
BackgroundAlthough elevated homocysteine levels have been shown to affect penile erection, the relationship between homocysteine and erection at the...
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Association of homocysteine with white matter dysconnectivity in schizophrenia
Several studies have shown white matter (WM) dysconnectivity in people with schizophrenia (SZ). However, the underlying mechanism remains unclear. We...
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Homocysteine serum levels correlate with the number of failed IVF cycles even when within normal range
IntroductionRepeated implantation failure is a common challenge in daily practice. Homocysteine and vitamin B12 have been associated with...
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High homocysteine is associated with idiopathic normal pressure hydrocephalus in deep perforating arteriopathy: a cross-sectional study
Background and objectiveThe pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) remain unclear. Homocysteine may...
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Hypertension and cystatin C account for sex differences in serum homocysteine levels in acute coronary syndrome subjects with normal serum creatinine
BackgroundHyperhomocysteinemia is one of cardiovascular disease risk factors and fasting homocysteine levels are significantly elevated in male...
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Folic acid supplementation on inflammation and homocysteine in type 2 diabetes mellitus: systematic review and meta-analysis of randomized controlled trials
BackgroundThe beneficial effects of folate have been observed under different conditions, but the available evidence on inflammation and reduction of...
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The effect of folic acid supplementation on damage caused by chronic cerebral hypo-perfusion in the hippocampus: the role of antioxidant agents and homocysteine
PurposeOxidative stress is known as the dominant factor in the damage caused by ischemia. Also, clinical studies have shown that the amount of folic...
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Association between homocysteine and coronary artery disease—trend over time and across the regions: a systematic review and meta-analysis
BackgroundThe association of homocysteine with coronary artery disease (CAD) has been explored previously with mixed findings. The present Systematic...
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The vicious circle between homocysteine, methyl group-donating vitamins and chronic levodopa intake in Parkinson’s disease
A biomarker for declined methylation capacity is elevation of homocysteine levels. They increase the risk for onset of vascular disease and...
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Homocysteine levels, genetic background, and cognitive impairment in Parkinson’s disease
BackgroundHyperhomocysteinemia is considered an independent risk factor for cognitive impairment.
ObjectiveTo study the correlation between...
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Higher serum homocysteine levels are associated with an increased risk of hemorrhagic transformation in patients with acute ischemic stroke
BackgroundHemorrhagic transformation (HT) is a common complication of acute ischemic stroke (AIS), and may develop into parenchyma hemorrhage (PH)....
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Homocysteine, vitamin B metabolites, dopamine-substituting compounds, and symptomatology in Parkinson’s disease: clinical and therapeutic considerations
Emerging studies suggest a correlation between elevated plasma homocysteine (hcy) levels and the risk of atherosclerosis, vascular disorders, and...
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Plasma metabolomic profile in orthostatic intolerance children with high levels of plasma homocysteine
BackgroundOrthostatic intolerance, which includes vasovagal syncope and postural orthostatic tachycardia syndrome, is common in children and...
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Follicular homocysteine as a marker of oocyte quality in PCOS and the role of micronutrients
PurposeDoes follicular homocysteine predict the reproductive potential of oocytes following FSH stimulation in PCOS women? Can it be modulated by...
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Changes in homocysteine and non-mercaptoalbumin levels after acute exercise: a crossover study
BackgroundAcute exercise is one factor that increases blood homocysteine levels, and elevated homocysteine levels cause oxidative stress. Albumin,...
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Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs
BackgroundEpilepsy is a neurological disease that requires long-term antiepileptic drugs (AEDs). The old generation of AEDs may affect serum...
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Prognostic implications of obstructive sleep apnea in patients with acute coronary syndrome stratified by homocysteine level: a prospective cohort study
BackgroundSporadic studies have examined the impact of OSA on ACS patients by homocysteine (Hcy) level. This study attempted to comprehensively...
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Association of osteoporosis and high serum homocysteine levels with intraoperative periprosthetic fracture during total hip arthroplasty: a propensity-score matching analysis
IntroductionIntraoperative periprosthetic fracture, one of the most frequent complications of total hip arthroplasty, is a very important factor that...
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Relationship of serum homocysteine and vitamin D with positive, negative, and extrapyramidal symptoms in schizophrenia: a case–control study in Iran
BackgroundSchizophrenia is a devastating condition characterized by frequent recurrences, cognitive decline, and emotional and functional...
