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Incidental hypertransaminasemia in children—a stepwise approach in primary care
Children with elevated liver enzymes are occasionally discovered through laboratory work-up from different clinical scenarios. Although the majority...
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Unconjugated bilirubin as a state marker in patients with schizophrenia in acute episode: an Egyptian study
BackgroundThere is a substantial body of evidence linking unconjugated bilirubin to schizophrenia. Most of the earlier research has found a...
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The potential immuno-stimulating effect of curcumin, piperine, and taurine combination in hepatocellular carcinoma; a pilot study
BackgroundThis is a phase II clinical trial to investigate the immunotherapeutic effect of Curcumin, Piperine, and Taurine (CPT) combination in...
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Hyperthyroxinemia at birth: a cause of idiopathic neonatal hyperbilirubinemia?
BackgroundSome neonates develop idiopathic hyperbilirubinemia (INHB) requiring phototherapy, yet with no identifiable causes. We searched for an...
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The frequency, clinical course, and health related quality of life in adults with Gilbert’s syndrome: a longitudinal study
BackgroundGilbert syndrome (GS) is an autosomal recessive inherited disorder of bilirubin glucuronidation which has not been investigated in Egypt....
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Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients
IntroductionBecause of the high mortality of invasive fungal infections (IFIs), appropriate exposure to antifungals appears to be crucial for...
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How to apply clinical cases and medical literature in the framework of a modified “failure mode and effects analysis” as a clinical reasoning tool – an illustration using the human biliary system
BackgroundClinicians use various clinical reasoning tools such as Ishikawa diagram to enhance their clinical experience and reasoning skills. Failure...
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Advances in sepsis-associated liver dysfunction
Recent studies have revealed liver dysfunction as an early event in sepsis. Sepsis-associated liver dysfunction is mainly resulted from systemic or...
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Therapeutic hepatocyte transplant for inherited metabolic disorders: functional considerations, recent outcomes and future prospects
The applications, outcomes and future strategies of hepatocyte transplantation (HTx) as a corrective intervention for inherited metabolic disease...
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Considerations in the Pharmacologic Treatment and Prevention of Neonatal Sepsis
The management of neonatal sepsis is challenging owing to complex developmental and environmental factors that contribute to inter-individual...
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Predictors of significant jaundice in late preterm infants
ObjectivesTo study ( i ) the incidence and course of jaundice, and ( ii ) the predictors of ‘significant jaundice’ in late preterm infants.
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Pharmacokinetic Optimization of Antiretroviral Therapy in Pregnancy
Antiretroviral therapy suppresses replication of HIV allowing restoration and/or preservation of the immune system. Providing combination...
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Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice
Trabectedin is a novel anticancer drug active against soft tissue sarcomas. Trabectedin is a substrate for P-glycoprotein (P-gp), which is encoded by mdr1a/1b...
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Screening Newborns for Galactosemia Using Total Body Galactose Oxidation to CO2 in Expired Air
Classic galactosemia is caused by impaired galactose-1-phosphate uridyltransferase (GALT EC 2.7.712). If discovered and treated within the first days...
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Safety and Toxicity of Sulfadoxine/Pyrimethamine
Plasmodium falciparum infection during pregnancy is strongly associated with maternal anaemia and low birth weight, contributing to substantial...
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A Randomized, Triple-Blind, Placebo-Controlled Trial of Prophylactic Oral Phenobarbital to Reduce the Need for Phototherapy in G6PD-Deficient Neonates
OBJECTIVE:Decreased conjugation is probably more important than hemolysis for causing jaundice in G6PD-deficient neonates. The role of enzyme...
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Adverse drug reactions, transcription factors and transcriptomics
It is currently believed that most idiosyncratic adverse drug reactions arise because of enzymatic modification of the parent drug structure to...