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Heme oxygenase 1 in erythropoiesis: an important regulator beyond catalyzing heme catabolism
Heme oxygenase 1 (HO-1), encoded by the HMOX-1 gene, is the main heme oxygenase that catalyzes the degradation of heme into iron, carbon monoxide,...
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Heme Oxygenase-1, Cardiac Senescence, and Myocardial Infarction: A Critical Review of the Triptych
PurposeHeme oxygenase-1 (HO-1) is a crucial enzyme in heme metabolism, facilitating the breakdown of heme into biliverdin, carbon monoxide, and free...
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Heme oxygenase-1 deficiency as an extremely rare cause of AA-type renal amyloidosis: Expanding the clinical features and review of the literature
Heme oxygenase-1 (HMOX-1) is an enzyme that regulates heme degradation. Antiinflammatory, antioxidant, and cytoprotective effects of HMOX-1 were also...
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Association between heme oxygenase one and sepsis development in patients with moderate-to-critical COVID-19: a single-center, retrospective observational study
BackgroundHeme oxygenase one (HO-1) is considered a poor prognostic factor for survival in patients with severe-to-critical coronavirus disease...
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Heme Oxygenase-1-Modified BMMSCs Activate AMPK–Nrf2–FTH1 to Reduce Severe Steatotic Liver Ischemia–Reperfusion Injury
BackgroundIschemia–reperfusion injury (IRI) is an important cause of graft dysfunction post-liver transplantation, where donor liver with severe...
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M2 tumor-associated macrophages resist to oxidative stress through heme oxygenase-1 in the colorectal cancer tumor microenvironment
M2 tumor-associated macrophages (M2-TAMs) promote cancer cell proliferation and metastasis in the TME. Our study aimed to elucidate the mechanism of...
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The dual role and mutual dependence of heme/HO-1/Bach1 axis in the carcinogenic and anti-carcinogenic intersection
IntroductionIn physiological concentrations, heme is nontoxic to the cell and is essential for cell survival and proliferation. Increasing...
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Importance of Heme Oxygenase-1 in Gastrointestinal Cancers: Functions, Inductions, Regulations, and Signaling
IntroductionColorectal cancer (CRC) is one of the important gastrointestinal tract tumors. Heme is mainly absorbed in the colon and...
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Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares
BackgroundHeme oxygenase-1 (HMOX1) catalyzes the metabolism of heme into carbon monoxide, ferrous iron, and biliverdin. Through biliverdin reductase,...
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The ethanolic extract of Curcuma longa grown in Korea exhibits anti-neuroinflammatory effects by activating of nuclear transcription factor erythroid-2-related factor 2/heme oxygenase-1 signaling pathway
BackgroundCurcuma longa has been used as spices, food preservative, coloring material, and traditional medicine. This plant also has long been used...
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Heme oxygenase-1 and neopterin plasma/serum levels and their role in diagnosing active and latent TB among HIV/TB co-infected patients: a cross sectional study
BackgroundTuberculosis (TB) diagnosis in the context of HIV co-infection remains challenging. Heme oxygenase 1 (HO-1) and neopterin have been...
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Heme-regulated inhibitor: an overlooked eIF2α kinase in cancer investigations
Heme-regulated inhibitor (HRI) kinase is a serine–threonine kinase, controlling the initiation of protein synthesis via phosphorylating α subunit of...
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Subjects with coronary artery disease and reduced ejection fraction have longer (GT)n repeats in the heme-oxygenase 1 gene promoter
Heme oxygenase (HO)-1 is a rate-limiting enzyme for degrading heme into carbon monoxide. Longer (GT) n repeat of the HO-1 gene (HMOX1) promoter has a...
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Serum heme oxygenase-1 measurement is useful for evaluating disease activity and outcomes in patients with acute respiratory distress syndrome and acute exacerbation of interstitial lung disease
BackgroundOxidative stress plays an important role in acute lung injury, which is associated with the development and progression of acute...
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Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier
The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model...
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Regulatory mechanisms of heme regulatory protein BACH1: a potential therapeutic target for cancer
A limited number of overexpressed transcription factors are associated with cancer progression in many types of cancer. BTB and CNC homology 1...
