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Maternal Uterine Artery Adenoviral Vascular Endothelial Growth Factor (Ad.VEGF-A165) Gene Therapy Normalises Fetal Brain Growth and Microglial Activation in Nutrient Restricted Pregnant Guinea Pigs
Fetal growth restriction (FGR) is associated with uteroplacental insufficiency, and neurodevelopmental and structural brain deficits in the infant....
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Effects of Gestational Hypoxia on PGC1α and Mitochondrial Acetylation in Fetal Guinea Pig Hearts
Chronic intrauterine hypoxia is a significant pregnancy complication impacting fetal heart growth, metabolism, and mitochondrial function,...
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Chronic Hypoxia Inhibits Respiratory Complex IV Activity and Disrupts Mitochondrial Dynamics in the Fetal Guinea Pig Forebrain
Mitochondrial dysfunction is an underlying cause of childhood neurological disease secondary to the crucial role of mitochondria in proper...
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Fetal neurosurgery
Among fetal surgical procedures, neurosurgery stands out due to the number of cases and the possibility of develo** new procedures that can be...
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Neuroprotective effects of maternal melatonin administration in early-onset placental insufficiency and fetal growth restriction
BackgroundEarly-onset fetal growth restriction (FGR) is associated with adverse outcomes. We hypothesised that maternal melatonin administration will...
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A DIO2 missense mutation and its impact on fetal response to PRRSV infection
BackgroundPorcine reproductive and respiratory syndrome virus 2 (PRRSV-2) infection during late gestation substantially lowers fetal viability and...
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Nicotinamide Riboside, an NAD + Precursor, Protects Against Cardiac Mitochondrial Dysfunction in Fetal Guinea Pigs Exposed to Gestational Hypoxia
Gestational hypoxia inhibits mitochondrial function in the fetal heart and placenta contributing to fetal growth restriction and organ dysfunction....
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Sex-Selective Increase of IGF-2 Expression in the Hypoxic Guinea Pig Placenta of Growth-Restricted Fetuses
Chronic hypoxia can cause fetal growth restriction (FGR) through placental dysfunction. Insulin-like growth factors (IGFs), such as IGF-2, play a...
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Embryonic mouse medial neocortex as a model system for studying the radial glial scaffold in fetal human neocortex
Neocortex is the evolutionarily newest region in the brain, and is a structure with diversified size and morphology among mammalian species. Humans...
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Sexual dimorphisms in brain gene expression in the growth-restricted guinea pig can be modulated with intra-placental therapy
BackgroundFetal responses to adverse pregnancy environments are sex-specific. In fetal guinea pigs (GPs), we assessed morphology and messenger RNA...
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Cerebroprotective actions of hydrogen sulfide in the epileptic brain in newborn pigs
BackgroundNeonatal epileptic seizures cause postictal dysregulation of cerebral blood flow. Hydrogen sulfide (H 2 S), a mediator with vasodilator and...
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The acceptability and feasibility of a randomised trial exploring approaches to managing impacted fetal head during emergency caesarean section: a qualitative study
BackgroundCaesarean sections (CS) account for 26% of all births in the UK, of which at least 5% are done at full dilatation, in the second stage of...
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Fetal lung development via quantitative biomarkers from diffusion MRI and histological validation in rhesus macaques
ObjectiveTo demonstrate sensitivity of diffusion-weighted MRI (DW-MRI) to pulmonary cellular-space changes during normal in utero development using...
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Fetal hypoxia and apoptosis following maternal porcine reproductive and respiratory syndrome virus (PRRSV) infection
BackgroundMechanisms of fetal death following maternal PRRSV2 infection remain uncharacterized, although hypoxia from umbilical cord lesions and/or...
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The cavernous carotid inferolateral trunk and persistent primitive maxillary arteries: analysis of dissected arterially injected fetal specimens and high-resolution micro-CT of the dog’s anastomotic arteries
PurposeThe presence of a persistent primitive maxillary artery is described in the literature dealing with the development of the cavernous carotid...
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Brain-derived neurotrophic factor protects serotonergic neurons against 3,4-methylenedioxymethamphetamine (“Ecstasy”) induced cytoskeletal damage
3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) use has been linked to persistent alterations of the brain serotonergic (5-HT) system in animal...
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Organ Fabrication: Progress and Hurdles to Overcome
Purpose of reviewAlthough technological advancements in the genetic modification of pigs have renewed the interest in experiments involving the...
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Impairment in neurocognitive function following experimental neonatal guinea pig cytomegalovirus infection
BackgroundCytomegalovirus (CMV) is a leading infectious cause of neurologic deficits, both in the settings of congenital and perinatal infection, but...
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Perinatal compromise affects development, form, and function of the hippocampus part two; preclinical studies
AbstractThe hippocampus is a vital brain structure deep in the medial temporal lobe that mediates a range of functions encompassing emotional...
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Early cleaving embryos result in blastocysts with increased aspartate and glucose consumption, which exhibit different metabolic gene expression that persists in placental and fetal tissues
ObjectivesUsing time-lapse microscopy, previous research has shown that IVF mouse embryos that cleave earlier at the first division (‘fast’) develop...
