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Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma
There is a critical need to identify new therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Transcriptional co-regulators...
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ERBB2 Targeting Reveals a Significant Suppression of Tumorigenesis in Murine Endometrial Cancer with Pten Mutation
Endometrial cancer is the most common gynecologic malignancy. PTEN is a negative regulator of PI3K signaling and is deficient in > 50% of primary...
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Multivalent adaptor proteins specifically target NK cells carrying a universal chimeric antigen receptor to ErbB2 (HER2)-expressing cancers
Chimeric antigen receptor (CAR)-engineered immune effector cells constitute a promising approach for adoptive cancer immunotherapy. Nevertheless,...
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Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy
The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits,...
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Epiregulin confers EGFR-TKI resistance via EGFR/ErbB2 heterodimer in non-small cell lung cancer
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective against non-small cell lung cancer (NSCLC) with EGFR -activating...
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Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition
Oesophageal adenocarcinoma (OAC) patients show poor survival rates and there are few targeted molecular therapies available. However, components of...
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Molecular insights of exercise therapy in disease prevention and treatment
Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the prevention and treatment of various diseases, the underlying...
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Insulin and the insulin receptor collaborate to promote human gastric cancer
BackgroundGastric adenocarcinoma is common and consequent mortality high. Presentation and mortality are increased in obese individuals, many of whom...
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BET-directed PROTACs in triple negative breast cancer cell lines MDA-MB-231 and MDA-MB-436
PurposeThis study aims to find whether the proliferation and migration of triple negative breast cancer (TNBC) cell lines can be reduced by treatment...
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A real-world study and network pharmacology analysis of EGFR-TKIs combined with ZLJT to delay drug resistance in advanced lung adenocarcinoma
ObjectiveThis study aimed to explore the efficacy and safety of combining epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)...
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Differential expression profiling of onco and tumor-suppressor genes from major-signaling pathways in Wilms’ tumor
PurposeWilms’ tumor is the most-frequent malignant-kidney tumor in children under 3–4 years of age and is caused by genetic alterations of oncogenes...
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ERRα: unraveling its role as a key player in cell migration
Cell migration is essential throughout the life of multicellular organisms, and largely depends on the spatial and temporal regulation of...
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To be, or not to be: the dilemma of immunotherapy for non-small cell lung cancer harboring various driver mutations
IntroductionLung cancer is one of primary cancer type with high incidence and mortality, non-small cell lung cancer (NSCLC) is the most common type...
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Driver and targetable alterations in Chinese patients with small bowel carcinoma
PurposeSmall bowel carcinoma (SBA) is a rare gastrointestinal cancer with a poor prognosis. Recent genomic profiling studies revealed that the...
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Protein lipidation in health and disease: molecular basis, physiological function and pathological implication
Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal...
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Investigation of HER2 I655V and PHB 3′UTR C > T polymorphisms in azoospermic infertile males
BackgroundMale infertility is a complex, multifactorial pathological condition with a highly heterogeneous phenotypic variation, from complete...
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AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors
The PI3K pathway is commonly activated in breast cancer, with PI3K-AKT pathway inhibitors used clinically. However, mechanisms that limit or enhance...
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Synchronous cancers of the stomach and esophagus in a patient with autoimmune gastritis and pernicious anemia: a case report and review of the literature
Type-A gastritis/autoimmune gastritis (AIG) has gained renewed attention due to declining Helicobacter pylori infection rates and increasing...
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HER2-Positive Metastatic Colorectal Cancer
Targeted treatment strategies are available for human epidermal growth factor receptor 2 (HER2)–positive (amplified and/or overexpressed) metastatic...
