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Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer’s disease in mice
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with cognitive dysfunction as its major clinical symptom. However, there is no...
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Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancer
BackgroundCetuximab, a monoclonal antibody targeting epidermal growth factor receptor (EGFR), is effective for RAS wild-type metastatic colorectal...
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In-vivo inhibition of neutral endopeptidase 1 results in higher absorbed tumor doses of [177Lu]Lu-PP-F11N in humans: the lumed phase 0b study
BackgroundA new generation of radiolabeled minigastrin analogs delivers low radiation doses to kidneys and are considered relatively stable due to...
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Neutral endopeptidase depletion decreases colon cancer cell proliferation and TGF-β1 synthesis in indirect co-cultures with normal colon fibroblasts
PurposeAlthough recent studies have suggested that neutral endopeptidase (NEP) is implicated in the regulation of colon cancer (CC) cell growth and...
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Effect of Qinbai Qingfei Concentrated Pellets on substance P and neutral endopeptidase of rats with post-infectious cough
BackgroundIn recent years, it has been reported that Qinbai Qingfei Concentrated Pellet (QQCP) has the effect of relieving cough and reducing sputum....
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Pyroptosis -related potential diagnostic biomarkers in steroid-induced osteonecrosis of the femoral head
PurposeSteroid-induced necrosis of the femoral head (SONFH) is a refractory orthopedic hip disease occurring in young and middle-aged people, with...
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The glycoproteomics of hawk and caiman tears
BackgroundGlycoproteins are important tear components that participate in the stability of the ocular surface. However, the glycopeptides that are...
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Establishment of FAP-overexpressing Cells for FAP-targeted Theranostics
ObjectiveFibroblast activation protein (FAP) has been widely studied and exploited for its clinical applications. One of the difficulties in...
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Identification and characterization of RSIY-11, a novel seminal peptide derived from semenogelin-1, which acts as a neutral endopeptidase inhibitor modulating sperm motility
PurposeBased on prior reports demonstrating that neutral endopeptidase (NEP) inhibitors increase sperm motility, the goal of our studies was to...
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The putative pleiotropic functions of meprin β in gastric cancer
BackgroundThe gastric microbiome and inflammation play a key role in gastric cancer (GC) by regulating the immune response in a complex manner and by...
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Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson’s disease
Gut dysbiosis contributes to Parkinson’s disease (PD) pathogenesis. Gastrointestinal disturbances in PD patients, along with gut leakage and...
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Imlifidase as a Potential Treatment for Antibody-Mediated Rejection
Purpose of ReviewAntibody-mediated rejection (ABMR) is implicated as the leading cause of late kidney allograft failure. Current therapies...
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C/EBPβ/AEP signaling couples atherosclerosis to the pathogenesis of Alzheimer’s disease
Atherosclerosis (ATH) and Alzheimer’s disease (AD) are both age-dependent inflammatory diseases, associated with infiltrated macrophages and vascular...
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Construction of a prognostic model for autophagy in Wilm's tumor
BackgroundWilm's tumor (WT) is one of the most common childhood urological tumors, ranking second in the incidence of pediatric abdominal tumors. The...
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Whole-exome sequencing revealed a novel homozygous missense variant in OSGEP gene: a case report of Galloway–Mowat syndrome in Iran
Galloway–Mowat syndrome is a rare autosomal-recessive genetic disorder that is characterized by variety of complications such as neurological...
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Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon cancer
BackgroundThe most common cause of death for colon cancer patients is liver metastasis.
MethodsAll the data enrolled in this study were downloaded...
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Network analysis of plasma proteomes in affective disorders
The conventional differentiation of affective disorders into major depressive disorder (MDD) and bipolar disorder (BD) has insufficient biological...
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Role of ferroptosis-related genes in coronary atherosclerosis and identification of key genes: integration of bioinformatics analysis and experimental validation
BackgroundCoronary atherosclerosis (CA) is the most common type of atherosclerosis. However, the inherent pathogenesis and mechanisms of CA are...
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Machine learning and molecular subtype analyses provide insights into PANoptosis-associated genes in rheumatoid arthritis
BackgroundPANoptosis represents a newly identified form of programmed cell death that plays a significant role in the autoimmune diseases. Rheumatoid...
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Mechanism exploration of Osteoking in the treatment of lumbar disc herniation based on network pharmacology and molecular docking
ObjectiveLumbar disc herniation (LDH) is a common spinal surgical disease. Low back and leg pain caused by LDH is the main factor leading to...
