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Generation and application of immortalized sheep fetal fibroblast cell line
BackgroundPrimary sheep fetal fibroblasts (SFFCs) have emerged as a valuable resource for investigating the molecular and pathogenic mechanisms of...
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20 Years with SGBS cells - a versatile in vitro model of human adipocyte biology
20 years ago, we described a human cell strain derived from subcutaneous adipose tissue of an infant supposed to have Simpson-Golabi-Behmel Syndrome...
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Transcriptomic analysis of spleen B cell revealed the molecular basis of bursopentin on B cell differentiation
The bursa of Fabricius, the acknowledged humoral immune organ unique to birds, plays a vital role in B cell development. Bursopentin (BP5) derived...
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The Epstein–Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization
Epstein–Barr virus (EBV) immortalizes human B-lymphocytes and is implicated in the pathogenesis of lymphoid and epithelial cell malignancies. The EBV...
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The peculiar features, diversity and impact of citrulline-reactive autoantibodies
Since entering the stage 25 years ago as a highly specific serological biomarker for rheumatoid arthritis, anti-citrullinated protein antibodies...
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Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis
BackgroundRecent studies have investigated the role of Helicobacter pylori infection in the development of gastric mucosa-associated lymphoid tissue...
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Hitting Epstein Barr virus where it hurts: computational methods exploration for siRNA therapy in alleviating Epstein Barr virus-induced multiple sclerosis
Multiple sclerosis (MS), an intricate neurological disorder, continues to challenge our understanding of the pivotal interplay between the immune...
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Extraction and identification of exosomes from three different sources of human ovarian granulosa cells and analysis of their differential miRNA expression profiles
ObjectiveAs important functional cells in the ovary, ovarian granulosa cells are involved in the regulation of oocyte growth and development and play...
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Prevalence of Epstein Barr Virus and Herpes Simplex Virus Among Human Papillomavirus Negative Oral Cancer Patients: A Cross-Sectional Study from South India
The high incidence of oral carcinomas is due to its multifactorial etiology and the presence of various risk factors. Human Papillomavirus (HPV) has...
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Live attenuated VZV vaccination induces antitumor immunity in ATLL patients
Adult T cell leukemia/lymphoma (ATLL) is a CD4-positive peripheral T cell lymphoma caused by human T cell lymphotropic virus type 1 (HTLV-1)....
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Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas
Intraductal tubulopapillary neoplasm (ITPN) is a distinct precancerous lesion in the pancreas with unique clinical and molecular features. Although...
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The expression level of chicken telomerase reverse transcriptase in tumors induced by ALV-J is positively correlated with methylation and mutation of its promoter region
Avian leukosis virus subgroup J (ALV-J) can cause neoplastic diseases in poultry and is still widely prevalent in China. Chicken telomerase reverse...
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Polyploid giant cancer cells, stemness and epithelial-mesenchymal plasticity elicited by human cytomegalovirus
A growing body of evidence is recognizing human cytomegalovirus (HCMV) as a potential oncogenic virus. We hereby provide the first experimental in...
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Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
Cancer is one of the major diseases threatening human life and health worldwide. Epigenetic modification refers to heritable changes in the genetic...
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H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair
Chondrocyte differentiation is a critical process for endochondral ossification, which is responsible for long bone development and fracture repair....
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Harnessing innate immune pathways for therapeutic advancement in cancer
The innate immune pathway is receiving increasing attention in cancer therapy. This pathway is ubiquitous across various cell types, not only in...
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Salinomycin decreases feline sarcoma and carcinoma cell viability when combined with doxorubicin
BackgroundCancer is a significant health threat in cats. Chemoresistance is prevalent in solid tumors. The ionophore salinomycin has anti-cancer...
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Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry
Abdominal paragangliomas and pheochromocytomas (PPGLs) are rare neuroendocrine tumors of the infradiaphragmatic paraganglia and adrenal medulla,...
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Formalin-killed Propionibacterium acnes activates the aryl hydrocarbon receptor and modifies differentiation of SZ95 sebocytes in vitro
BackgroundAcne vulgaris is a common pilosebaceous disease associated with Propionibacterium acnes ( P. acnes ). Resolution of comedones may occur in...
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Tumor biomarkers for diagnosis, prognosis and targeted therapy
Tumor biomarkers, the substances which are produced by tumors or the body’s responses to tumors during tumorigenesis and progression, have been...
