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The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation
The innate immune response is the main pathophysiological process of ocular surface diseases exposed to multiple environmental stresses. The...
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Gene polymorphisms of molecules of the cGAS-STING signalling pathway are associated with AML in Chinese patients
PurposeThe aim of this study was to explore the relationships between single-nucleotide polymorphisms (SNPs) of crucial molecules in the cGAS-STING...
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Phase separation in cGAS-STING signaling
Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes....
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Investigating the effects of PTEN mutations on cGAS-STING pathway in glioblastoma tumours
BackgroundPTEN is a tumour suppressor gene and well-known for being frequently mutated in several cancer types. Loss of immunogenicity can also be...
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Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway
The mitotic MTH1 inhibitor TH1579 is a dual inhibitor that inhibits mitosis and incorporation of oxidative DNA damage and leads to cancer-specific...
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Experimental congenital diaphragmatic hernia features an alteration of DNA sensing targets cGAS and STING
BackgroundThe pathogenesis of congenital diaphragmatic hernia (CDH) depends on multiple factors. Activation of the DNA-sensing...
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Role of the cGAS–STING pathway in systemic and organ-specific diseases
Cells are equipped with numerous sensors that recognize nucleic acids, which probably evolved for defence against viruses. Once triggered, these...
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PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer
BackgroundColorectal cancer (CRC) lacks established biomarkers or molecular targets for predicting or enhancing radiation response....
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Carbon ion irradiation induces DNA damage in melanoma and optimizes the tumor microenvironment based on the cGAS–STING pathway
PurposesIncreased number of studies reveal the crucial role of the Cyclic GMP–AMP synthase/stimulator of interferon genes (cGAS/STING) pathway in...
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Role of the cGAS-STING pathway in regulating the tumor-immune microenvironment in dMMR/MSI colorectal cancer
Deficient mismatch repair (dMMR)/microsatellite instability (MSI) colorectal cancer (CRC) has high immunogenicity and better prognosis compared with...
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Cytosolic mtDNA–cGAS–STING axis contributes to sepsis-induced acute kidney injury via activating the NLRP3 inflammasome
BackgroundNLRP3 inflammasome activation is significantly associated with sepsis-induced acute kidney injury (S-AKI). Cytosolic DNA derived from...
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The tumor cell-intrinsic cGAS–STING pathway is associated with the high density of CD8+ T cells after chemotherapy in esophageal squamous cell carcinoma
BackgroundChemotherapy has the potential to induce CD8 + T-cell infiltration in the tumor microenvironment (TME) and activate the anti-tumor immune...
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African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-β pathway activation by degrading TBK1
African swine fever virus (ASFV) is an important pathogen causing acute infectious disease in domestic pigs and wild boars that seriously endangers...
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Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases
BackgroundThere is increasing evidence for the role of inflammation in the pathogenesis of mitochondrial diseases (MDs). However, the mechanisms...
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An overview of the crosstalk between YAP and cGAS-STING signaling in non-small cell lung cancer: it takes two to tango
The cyclic GMP-AMP synthase (cGAS)—stimulator of interferon genes (STING) pathway is recognized as a main mediator bridging innate and adaptive...
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The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages
BackgroundHBV infection can result in severe liver diseases and is one of the primary causes of liver cell carcinoma-related mortality. Liuwei Wuling...
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African swine fever virus MGF360-11L negatively regulates cGAS-STING-mediated inhibition of type I interferon production
The type I interferon (IFN-I) signaling pathway is an important part of the innate immune response and plays a vital role in controlling and...
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A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway
Pseudomonas aeruginosa infection continues to be a major threat to global public health, and new safe and efficacious vaccines are needed for...
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Targeting the DNA damage response enhances CD70 CAR-T cell therapy for renal carcinoma by activating the cGAS-STING pathway
Chimeric antigen receptor T-cell (CAR-T) therapy has shown tremendous success in eradicating hematologic malignancies. However, this success has not...
