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Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk
Psychiatric and obstetric diseases are growing threats to public health and share high rates of co-morbidity. G protein-coupled receptor signaling...
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Autism-associated biomarkers: test–retest reliability and relationship to quantitative social trait variation in rhesus monkeys
BackgroundRhesus monkeys ( Macaca mulatta ) exhibit pronounced individual differences in social traits as measured by the macaque Social...
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Microarray evidence that 8-cell human embryos express some hormone family members including oxytocin
ObjectiveThis study is to discover hormone pathways active in early cleaving human embryos.
MethodsA list of 152 hormones and receptors were...
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Effects on gene expression and behavior of untagged short tandem repeats: the case of arginine vasopressin receptor 1a (AVPR1a) and externalizing behaviors
Genome-wide association studies (GWAS) of complex, heritable, behavioral phenotypes have yielded an incomplete accounting of the genetic influences....
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Gene expression analyses on multi-target mode of action of black cohosh in menopausal complaints – a pilot study in rodents
PurposeThis study aimed at assessing gene expression profiles in hippocampus and hypothalamus of ovariectomized (OVX) rats with or without treatment...
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Eagle eyed or bird brained?
The importance of the visual system to birds for behaviours from feeding, mate choice, flying, navigation and determination of seasons, together with...
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DNA methylation landscape in pregnancy-induced hypertension: progress and challenges
Gestational hypertension (PIH), especially pre-eclampsia (PE), is a common complication of pregnancy. This condition poses significant risks to the...
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Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors, with many GPCRs having crucial roles in endocrinology and...
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Childhood stress impairs social function through AVP-dependent mechanisms
Impaired social function is a core feature of many psychiatric illnesses. Adverse experiences during childhood increase risk for mental illness,...
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Biological principles for music and mental health
Efforts to integrate music into healthcare systems and wellness practices are accelerating but the biological foundations supporting these...
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Social interaction following prepubertal stress alters prefrontal gene expression associated with cell signalling and oligodendrocytes
Early-life adversity is associated with an increased risk of psychopathology, including mood disorders, later in life. Early-life stress affects...
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Corticotropin releasing hormone receptor CRHR1 gene is associated with tianeptine antidepressant response in a large sample of outpatients from real-life settings
Polymorphisms of genes involved in the hypothalamic–pituitary–adrenocortical (HPA) axis have been associated with response to several antidepressant...
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CDK6 is upregulated and may be a potential therapeutic target in enzalutamide-resistant castration-resistant prostate cancer
BackgroundAndrogen deprivation therapy (ADT) is still the first-line treatment of prostate cancer (PCa). However, after a certain period of therapy,...
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Genetics of structural and functional brain changes in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurological and developmental disorder characterized by social impairment and restricted interactive and...
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Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder which has strong genetic basis. Despite the rapidly rising...
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Recent Advances in the Pharmacological Management of Behavioral Disturbances Associated with Autism Spectrum Disorder in Children and Adolescents
Autism spectrum disorder (ASD) is a heterogeneous neuropsychiatric condition affecting an estimated one in 36 children. Youth with ASD may have...
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Effects of oxytocin and arginine vasopressin on the proliferation and differentiation of a serotonergic cell line
The neuropeptides oxytocin and arginine vasopressin (AVP) are involved in the regulation of social behavior and cognition. The current study analyzed...
