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FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development
Stem/progenitor cells differentiate into different cell lineages during organ development and morphogenesis. Signaling pathway networks and...
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Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development, tissue homeostasis, and cell...
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The role of wnt signaling in diabetes-induced osteoporosis
Osteoporosis, a chronic complication of diabetes mellitus, is characterized by a reduction in bone mass, destruction of bone microarchitecture,...
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Gastrodin inhibits prostate cancer proliferation by targeting canonical Wnt/β-catenin signaling pathway
Prostate cancer is an epithelial malignant tumor occurring in the prostate and is the most common malignant tumor in the male genitourinary system....
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Wnt/β-catenin signaling is a therapeutic target in anaplastic thyroid carcinoma
BackgroundAnaplastic thyroid carcinoma (ATC) is a highly aggressive malignancy that has consistently shown Wnt/β-catenin (canonical) signaling...
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Sevoflurane inhibits cholangiocarcinoma via Wnt/β-catenin signaling pathway
BackgroundCholangiocarcinoma (CCA) is a refractory malignancy derived from bile duct epithelial cells. This study aimed to explore the role and...
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YWHAG promotes colorectal cancer progression by regulating the CTTN-Wnt/β-catenin signaling axis
Colorectal cancer (CRC) ranks as the third most prevalent cancer type globally. Nevertheless, the fundamental mechanisms driving CRC progression...
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Targeting the IRE1α-XBP1s axis confers selective vulnerability in hepatocellular carcinoma with activated Wnt signaling
Liver-specific Ern1 knockout impairs tumor progression in mouse models of hepatocellular carcinoma (HCC). However, the mechanistic role of IRE1α in...
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Wnt/β-Catenin Signaling in Craniomaxillofacial Osteocytes
Purpose of ReviewThere is a growing appreciation within the scientific community that cells exhibit regional variation. Whether the variation is...
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A small molecule compound 759 inhibits the wnt/beta-catenin signaling pathway via increasing the Axin protein stability
Wnt/β-catenin signaling plays important role in cancers. Compound 759 is one of the compounds previously screened to identify inhibitors of the...
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Decreased expression of GEM in osteoarthritis cartilage regulates chondrogenic differentiation via Wnt/β-catenin signaling
BackgroundGEM (GTP-binding protein overexpressed in skeletal muscle) is one of the atypical small GTPase subfamily members recently identified as a...
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Biliary atresia: insights into mechanisms using a toxic model of the disease including Wnt and Hippo signaling pathways and microtubules
BackgroundMechanisms underlying bile duct injury in biliary atresia (BA) remain unclear and mechanisms of bile duct repair are unknown. This study...
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Wnt Signaling in Heart Development and Regeneration
Purpose of ReviewCardiovascular diseases are the leading cause of death worldwide, largely due to the limited regenerative capacity of the adult...
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WDR1 promotes prostate cancer progression through Wnt/β-catenin signaling
Prostate cancer (PCa) is the second most common cancer and the fifth leading cause of cancer-related death among men. A comprehensive understanding...
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Single-cell RNA-seq analysis reveals the Wnt/Ca2+ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration
BackgroundIncreasing studies have shown degeneration of nucleus pulposus cells (NPCs) as an critical part of the progression of intervertebral disc...
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ATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner
Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types, including osteoblast (OB) differentiation and function....
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LncRNA-NEAT1 blocks the Wnt/β-catenin signaling pathway by targeting miR-217 to inhibit trophoblast cell migration and invasion
ObjectiveThis study aimed to study the correlation between preeclampsia (PE) and lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1), and to...
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TGM2 accelerates migration and differentiation of BMSCs by activating Wnt/β-catenin signaling
BackgroundTransglutaminase 2 (TGM2) is a gene previously reported to be associated with the differentiation of bone marrow mesenchymal stem cells...
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Parathyroid hormone (1–34) retards the lumbar facet joint degeneration and activates Wnt/β-catenin signaling pathway in ovariectomized rats
PurposeFacet joint degeneration (FJD) is a major cause of low back pain. Parathyroid hormone (PTH) (1–34) is commonly used to treat osteoporosis....
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Urantide alleviates atherosclerosis-related liver and kidney injury via the Wnt/β-catenin signaling pathway in ApoE(−/−) mice
ObjectiveTo investigate the role of urantide in the prevention and treatment of atherosclerosis (AS)-related liver and kidney injury by antagonizing...
