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Anti-vinculin antibodies as a novel biomarker in Egyptian patients with systemic sclerosis
IntroductionSystemic sclerosis (SSc) is an autoimmune disorder that causes vasculopathy and scarring, most commonly in the lungs and skin, but it can...
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Heart Failure with Recovered Ejection Fraction in Patients with Vinculin Loss-of-function Variants
Predictors of myocardial recovery in heart failure (HF) are poorly understood. We explored if vinculin ( VCL ) variants are associated with myocardial...
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Anti-vinculin antibodies in scleroderma (SSc): a potential link between autoimmunity and gastrointestinal system involvement in two SSc cohorts
BackgroundSystemic sclerosis (SSc) is an autoimmune disorder and commonly presents with vascular system involvement and motility disorders in the...
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Increased talin–vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections
Talin and vinculin, both actin-cytoskeleton-related proteins, have been documented to participate in establishing bacterial infections, respectively,...
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The suppression of cell motility through the reduction of FAK activity and expression of cell adhesion proteins by hAMSCs secretome in MDA-MB-231 breast cancer cells
Breast cancer is a leading cause of death in women worldwide. Cancer therapy based on stem cells is considered as a novel and promising platform. In...
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T-cell and B-cell repertoire diversity are selectively skewed in children with idiopathic nephrotic syndrome revealed by high-throughput sequencing
BackgroundClinical studies suggest that the dysfunction of T cells and B cells may play an essential role in the pathogenesis of idiopathic nephrotic...
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Second-Generation Biomarker Testing for Irritable Bowel Syndrome Using Plasma Anti-CdtB and Anti-Vinculin Levels
BackgroundELISA testing for anti-CdtB and anti-vinculin can discriminate patients with irritable bowel syndrome with diarrhea (IBS-D) from those with...
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Effect of temporary freezing on postmortem protein degradation patterns
BackgroundA precise determination of time since death plays a major role in forensic routine. Currently available techniques for estimating the...
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Morphological changes and protein degradation during the decomposition process of pig cadavers placed outdoors or in tents—a pilot study
The delimitation of the postmortem interval (PMI) is of utmost importance in forensic science. It is especially difficult to determine the PMI in...
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Structure, signal transduction, activation, and inhibition of integrin αIIbβ3
Integrins are heterodimeric receptors comprising α and β subunits. They are expressed on the cell surface and play key roles in cell adhesion,...
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Identification of genes that promote PI3K pathway activation and prostate tumour formation
We have performed a functional in vivo mutagenesis screen to identify genes that, when altered, cooperate with a heterozygous Pten mutation to...
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Structure and function of the membrane microdomains in osteoclasts
The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an...
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A standard protocol for the analysis of postmortem muscle protein degradation: process optimization and considerations for the application in forensic PMI estimation
The analysis of postmortem protein degradation has become of large interest for the estimation of the postmortem interval (PMI). Although several...
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An MDM2 degrader for treatment of acute leukemias
In acute myeloid leukemia (AML), p53 tumor suppressor activity can be reduced due to enhanced expression of MDM2 which promotes the degradation of...
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A risk score model based on lipid metabolism-related genes could predict response to immunotherapy and prognosis of lung adenocarcinoma: a multi-dataset study and cytological validation
BackgroundLipid metabolism is a key factor in tumorigenesis and drug resistance, and models related to lipid metabolism have shown potential to...
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Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression
Histone deacetylase (HDAC) is a kind of protease that modifies histone to regulate gene expression, and is usually abnormally activated in tumors....
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Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer
BackgroundPeritoneal metastasis (PM) is an important factor contributing to poor prognosis in patients with gastric cancer (GC). Transcriptomic...
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USP54 is a potential therapeutic target in castration-resistant prostate cancer
BackgroundUSP54, a ubiquitin-specific protease in the deubiquitinase (DUB) family, facilitates the malignant progression of several types of cancer....
