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Multifocal micronodular pneumocyte hyperplasia lacking typical clinical features of the tuberous sclerosis complex: a case report and literature review
BackgroundMultifocal micronodular pneumocyte hyperplasia (MMPH) is a rare pulmonary manifestation of the tuberous sclerosis complex (TSC) with...
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The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019
BackgroundThe coronavirus disease 2019 (COVID-19) has induced a worldwide epidemiological event with a high infectivity and mortality. However, the...
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COVID-19 autopsies of Istanbul
Background/aimsThe aim of this study is to share autopsy findings of COVID-19-positive cases and autopsy algorithms for safely handling of suspicious...
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Autopsy findings of pediatric COVID-19: a systematic review
BackgroundLittle is known how COVID-19 is affecting children. Autopsies help gain an understanding of the pathophysiology of new and develo**...
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Quercetin ameliorates acute lung injury in a rat model of hepatopulmonary syndrome
BackgroundCommon bile duct ligation (BDL) is a rat experimental model to induce biliary cirrhosis. Lung fibrosis and pulmonary vascular angiogenesis...
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A mammalian lung's immune system minimizes tissue damage by initiating five major sequential phases of defense
The mammalian lungs encounter several pathogens, but have a sophisticated multi-phase immune defense. Furthermore, several immune responses to...
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Oxidative stress and NF-KB/iNOS inflammatory pathway as innovative biomarkers for diagnosis of drowning and differentiating it from postmortem submersion in both fresh and saltwater in rats
BackgroundFinding a dead body in water raises an issue concerning determining the cause of death as drowning because of the complex pathophysiology...
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Transbronchial biopsies’ histopathological findings leading to successful late steroid therapy in Covid-19 acute respiratory failure
We present results from clinical, radiologic, gas exchange, lung mechanics, and fibre-optic bronchoscopy-guided transbronchial biopsies in a case of...
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Low let-7d microRNA levels in chick embryos enhance innate immunity against Mycoplasma gallisepticum by suppressing the mitogen-activated protein kinase pathway
Chick embryos are a valuable model for studying immunity and vaccines. Therefore, it is crucial to investigate the molecular mechanism of the Mycoplasm...
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COVID-19: a Disease with a Potpourri of Histopathologic Findings—a Literature Review and Comparison to the Closely Related SARS and MERS
Since the coronavirus disease 2019 (COVID-19) pandemic has hit the entire world, there is ample knowledge regarding its clinical course and...
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The pulmonary pathology of COVID-19
The lung is the main affected organ in severe coronavirus disease 2019 (COVID-19) caused by the novel coronavirus SARS-CoV-2, and lung damage is the...
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Lung tissue expression of epithelial injury markers is associated with acute lung injury severity but does not discriminate sepsis from ARDS
BackgroundAcute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in critically ill patients, and diffuse alveolar damage...
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Sputum characteristics of patients with severe COVID-19: report of two cases with immunocytochemical detection of SARS-CoV-2 spike protein
Patients with SARS-CoV-2 infection and with severe COVID-19 often have multiple coinfections, and their treatment is challenging. Here, we performed...
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The effect of tracheal occlusion in congenital diaphragmatic hernia in the nitrofen rat lung explant model
PurposeHere, we establish a tracheal occlusion (TO) model with rat lung explants in nitrofen-induced pulmonary hypoplasia in the congenital...
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SARS-CoV-2 spread to endocrine organs is associated with obesity: an autopsy study of COVID-19 cases
PurposeSARS-CoV-2 infection may be limited to the respiratory tract or may spread to multiple organs. Besides disease severity, factors associated...
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Pulmonary hypertension— a novel phenotypic hypothesis of Kabuki syndrome: a case report and literature review
BackgroundPediatric pulmonary hypertension (PH) is a serious and rare disease that is often derived from genetic mutations. Kabuki syndrome (KS) is a...
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Autopsy findings in COVID-19 infection-related death: a systematic review
IntroductionCoronavirus-19 disease (COVID-19) has been declared as pandemic by the World Health Organization (WHO) in March 2020. As of 28 November...
