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Metastasis from follicular lymphoma to an ovarian mature teratoma: a case report of tumor-to-tumor metastasis
BackgroundTumor-to-tumor metastasis (TTM) is a rare but well-established phenomenon where histologically distinct tumors metastasize within each...
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Metastasis infiltrating tumor to meningioma: a case report
BackgroundThere have been many reports of tumor-to-tumor metastasis, in which cancer metastasizes directly into meningiomas. However, metastasis...
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Tumor-to-tumor spread: a case report and literature review of renal cell carcinoma metastasis into thyroid cancer
Tumor-to-tumor metastasis is a rare, yet important entity. Patients with a history of renal cell carcinoma (RCC) may have tumor deposits to the...
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Tumor-derived cell-free DNA and circulating tumor cells: partners or rivals in metastasis formation?
The origin of metastases is a topic that has sparked controversy. Despite recent advancements, metastatic disease continues to pose challenges. The...
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New insights into the correlations between circulating tumor cells and target organ metastasis
Organ-specific metastasis is the primary cause of cancer patient death. The distant metastasis of tumor cells to specific organs depends on both the...
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Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis
Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset of cancer patients. A better understanding of CTCs heterogeneity and...
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MicroRNAs mediated interaction of tumor microenvironment cells with breast cancer cells during bone metastasis
Breast cancer (BC) bone metastasis is primarily osteolytic and has limited therapeutic options. Metastasized BC cells prime the secondary environment...
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ID2 promotes tumor progression and metastasis in thyroid cancer
BackgroundInhibitor of DNA Binding 2 (ID2) plays a crucial role in tumor cell proliferation, invasion, metastasis, and stemness. Aberrant ID2...
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Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation
The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance of intra-tumoral bacteria, such...
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TREM1+ tumor-associated macrophages secrete CCL7 to promote hepatocellular carcinoma metastasis
PurposeTumor-associated macrophages (TAMs) play a critical role in hepatocellular carcinoma (HCC) progression and metastasis. Systematic...
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Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation
BRAF is frequently mutated in various cancer types and contributes to tumorigenesis and metastasis. As an important switch in RAS signaling pathway,...
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Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils
Breast cancer can metastasize to various organs, including the lungs. The immune microenvironment of the organs to be metastasized plays a crucial...
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Murine regulatory T cells utilize granzyme B to promote tumor metastasis
Regulatory T cells (Tregs) possess a wide range of mechanisms for immune suppression. Among them, Granzyme B (GzmB) and perforin expressed by Tregs...
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Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature
Breast cancer is a significant and deadly threat to women globally. Moreover, Breast cancer metastasis is a complicated process involving multiple...
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Phase separations in oncogenesis, tumor progressions and metastasis: a glance from hallmarks of cancer
Liquid–liquid phase separation (LLPS) is a novel principle for interpreting precise spatiotemporal coordination in living cells through biomolecular...
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Tumor-to-tumor metastasis of colon cancer metastasizing to a pancreatic neuroendocrine tumor associated with von Hippel-Lindau disease: a case report
Von Hippel-Lindau disease (VHL) is frequently associated with pancreatic neuroendocrine tumors (PNETs). Here, we report a case of tumor-to-tumor...
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The m6A reader IGF2BP3 preserves NOTCH3 mRNA stability to sustain Notch3 signaling and promote tumor metastasis in nasopharyngeal carcinoma
Metastasis remains the major cause of treatment failure in patients with nasopharyngeal carcinoma (NPC), in which sustained activation of the Notch...
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The role of innate immune cells as modulators of the tumor microenvironment in the metastasis and treatment of pancreatic cancer
Pancreatic cancer is a highly aggressive disease, which is often diagnosed late. Consequently, metastasis is common among newly diagnosed patients,...
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Neuroendocrine tumor of the minor duodenal papilla with lymph node metastasis: a case report and literature review
Whether pancreatoduodenectomy or papillary resection should be performed to achieve curative treatment for neuroendocrine tumors of the minor...
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Metastasis of breast cancer to bones alters the tumor immune microenvironment
BackgroundBone is one of the most frequent sites for breast cancer metastasis. Breast cancer bone metastasis (BCBM) leads to skeletal morbidities...
