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An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives
BackgroundIn recent years, 1, 2, 4-triazole and its derivatives have been reported to be pharmacologically significant scaffolds. They possess...
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Triazole analogues as potential pharmacological agents: a brief review
BackgroundA large number of studies have recently reported that, because of their significant biological and pharmacological properties, heterocyclic...
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Targeting Biometals in Alzheimer’s Disease with Metal Chelating Agents Including Coumarin Derivatives
Numerous physiological processes happening in the human body, including cerebral development and function, require the participation of biometal ions...
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Automated radiosynthesis and preclinical evaluation of two new PSMA-617 derivatives radiolabelled via [18F]AlF2+ method
BackgroundIn the last decade the development of new PSMA-ligand based radiopharmaceuticals for the imaging and therapy of prostate cancer has been a...
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In-silico and in-vitro analysis of novel substituted benzimidazolyl derivatives for antimycobacterial potentials targeting enoyl acyl carrier protein reductase (InhA)
BackgroundThe emergence of mutated drug-resistant strains of Mycobacterium tuberculosis has reinvigorated the development of effective chemotherapy...
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Medicinal chemistry aspects and synthetic strategies of coumarin as aromatase inhibitors: an overview
Coumarin is a bicyclic oxygen bearing heterocyclic scaffold formed by fusion of benzene with the pyrone ring. Because of its unique physicochemical...
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Inhibitory effect of O-propargyllawsone in A549 lung adenocarcinoma cells
BackgroundLung cancer is the deadliest type of cancer in the world and the search for compounds that can treat this disease is highly important....
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Recent Progress in Synthesis of 99mTc-labeled Complexes with Nitroimidazoles as SPECT Probes for Targeting Tumor Hypoxia
The majority of solid tumors have hypoxia, or low oxygen levels, which is one of the hallmarks of cancer. Hypoxia was found to relate to cancer...
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Synthesis, biological activity of newly designed sulfonamide based indole derivative as anti-microbial agent
BackgroundIn medicinal chemistry, indole and its derivative play an important role. Indole is gaining a lot of importance in medicinal chemistry due...
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Pyrimidine: a review on anticancer activity with key emphasis on SAR
BackgroundCancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance...
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Design, synthesis and antiproliferative evaluation of novel sulfanilamide-1,2,3-triazole derivatives as tubulin polymerization inhibitors
Microtubule as an important target in the cancer therapy was used to design novel tubulin polymerization inhibitors. Sulfanilamide-1,2,3-triazole...
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Piperidine nucleus in the field of drug discovery
BackgroundPiperidine is an essential heterocyclic system and a pivotal cornerstone in the production of drugs. Piperidine byproducts showed several...
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Investigation of the structure-activity relationship at the N-terminal part of minigastrin analogs
BackgroundOver the last years, several strategies have been reported to improve the metabolic stability of minigastrin analogs. However, currently...
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Genipin’s potential as an anti-cancer agent: from phytochemical origins to clinical prospects
This comprehensive review delves into the multifaceted aspects of genipin, a bioactive compound derived from medicinal plants, focusing on its...
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Endogenous fungal endophthalmitis caused by Cladophialophora devriesii: report of a case and literature review
PurposeTo report a case of endogenous endophthalmitis caused by the dematiaceous fungus Cladophialophora devriesii .
MethodsObservational case report...
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QSAR and molecular docking studies of novel 2,5-distributed-1,3,4-thiadiazole derivatives containing 5-phenyl-2-furan as fungicides against Phythophthora infestans
BackgroundThe 1,3,4-thiadiazoles are among the structural moieties that were found to be of utmost importance in the fields of pharmacy and...
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Therapeutic Innovations Against Opioid Tolerance and Addiction
Purpose of ReviewOpioids have a long history of use for relief of pain dating back thousands of years. Opium derived from the poppy plant is one of...
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Structural modifications toward improved lead-203/lead-212 peptide-based image-guided alpha-particle radiopharmaceutical therapies for neuroendocrine tumors
PurposeThe lead-203 ( 203 Pb)/lead-212 ( 212 Pb) elementally identical radionuclide pair has gained significant interest in the field of image-guided...
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Pharmaceutical significance of Schiff bases: an overview
Schiff bases are a diverse group of organic compounds with great pharmaceutical importance due to the presence of carbon–nitrogen double bonds...
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New analytical LC–MS/MS method for fluconazole and ivermectin estimation in combined pharmaceutical dosage form: development and validation
BackgroundFluconazole, an antifungal drug, prevents fungi growth by inhibiting the formation of a protective covering. Ivermectin has several...
