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Polygenic risk scores of lithium response and treatment resistance in major depressive disorder
Treatment response and resistance in major depressive disorder (MDD) are suggested to be heritable. Due to significant challenges in defining...
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Intestinal metabolites predict treatment resistance of patients with depression and anxiety
BackgroundThe impact of the gut microbiota on neuropsychiatric disorders has gained much attention in recent years; however, comprehensive data on...
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A multiparameter liquid biopsy approach allows to track melanoma dynamics and identify early treatment resistance
Melanoma heterogeneity is a hurdle in metastatic disease management. Although the advent of targeted therapy has significantly improved patient...
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Association between HIV and acquisition of rifamycin resistance with first-line TB treatment: a systematic review and meta-analysis
BackgroundMulti-drug or rifamycin-resistant tuberculosis (MDR/RR-TB) is an important public health concern, including in settings with high HIV...
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Genotype-stratified treatment for monogenic insulin resistance: a systematic review
BackgroundMonogenic insulin resistance (IR) includes lipodystrophy and disorders of insulin signalling. We sought to assess the effects of...
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Factors determining resistance to conventional disease-modifying anti-rheumatic drug treatment in oligoarticular juvenile idiopathic arthritis
ObjectiveOur study was designed to investigate the reasons for starting the conventional disease-modifying anti-rheumatic drugs (DMARDs) and the...
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High cure rates of Mycoplasma genitalium following empiric treatment with azithromycin alongside frequent detection of macrolide resistance in Austria
BackgroundMycoplasma genitalium (MG) is an emerging sexually transmitted infection, often harboring resistance-associated mutations to azithromycin...
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A Multicenter, Open-Label, Single-Arm Trial of the Efficacy and Safety of Empagliflozin Treatment for Refractory Diabetes Mellitus with Insulin Resistance (EMPIRE-01)
IntroductionInsulin resistance syndrome and lipoatrophic diabetes are characterized by severe insulin resistance and are often refractory to...
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Development and validation of a prediction model for unsuccessful treatment outcomes in patients with multi-drug resistance tuberculosis
BackgroundThe World Health Organization has reported that the treatment success rate of multi-drug resistance tuberculosis is approximately 57%...
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Increasing multidrug resistance in leech borne infections. Should we adjust antibiotic treatment regime in plastic surgery? A systematic review
BackgroundA growing number of reports of serious wound infections during medical leech therapy over the last decades caused by the leech gut symbiont
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Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance
The tumor microenvironment (TME) represents a milieu enabling cancer cells to develop malignant properties, while concerted interactions between...
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Bedaquiline resistance probability to guide treatment decision making for rifampicin-resistant tuberculosis: insights from a qualitative study
BackgroundBedaquiline (BDQ) is a core drug for rifampicin-resistant tuberculosis (RR-TB) treatment. Accurate prediction of a BDQ-resistant phenotype...
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High prevalence of pre-treatment HIV drug resistance in Papua New Guinea: findings from the first nationally representative pre-treatment HIV drug resistance study
BackgroundDetermining the prevalence of pre-treatment HIV drug resistance (PDR) is important to assess the effectiveness of first-line therapies. To...
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Repurposing of triamterene as a histone deacetylase inhibitor to overcome cisplatin resistance in lung cancer treatment
PurposeCisplatin is the core chemotherapeutic drug used for first-line treatment of advanced non-small cell lung cancer (NSCLC). However, drug...
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Supervised resistance exercise for women with ovarian cancer who have completed first-line treatment: a pragmatic study
ObjectivesIn ovarian cancer (OC), suboptimal muscle morphology (i.e., low muscle mass and density) is associated with poor clinical outcomes, yet...
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Janus kinase inhibitor overcomes resistance to immune checkpoint inhibitor treatment in peritoneal dissemination of gastric cancer in C57BL/6 J mice
BackgroundCancer immunotherapy aims to unleash the immune system’s potential against cancer cells, providing sustained relief for tumors responsive...
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Distinct roles of treatment schemes and BRCA2 on the restoration of homologous recombination DNA repair and PARP inhibitor resistance in ovarian cancer
Poly (ADP-ribose) polymerase inhibitors (PARPis) represent a major advance in ovarian cancer, now as a treatment and as a maintenance therapy in the...
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Antifungal Resistance, Susceptibility Testing and Treatment of Recalcitrant Dermatophytosis Caused by Trichophyton indotineae: A North American Perspective on Management
There is an ongoing epidemic of chronic, relapsing dermatophytoses caused by Trichophyton indotineae that are unresponsive to one or multiple...
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Clinical experience of treatment of immunocompromised individuals with persistent SARS-CoV-2 infection based on drug resistance mutations determined by genomic analysis: a descriptive study
BackgroundThe efficacy of antiviral drugs that neutralize antibody drugs and fight against SARS-COV-2 is reported to be attenuated by genetic...
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Antimicrobials in polymethylmethacrylate: from prevention to prosthetic joint infection treatment: basic principles and risk of resistance
BackgroundExcellent revisions about antibiotic-loaded bone cement (ALBC) have been recently published. In the present article, we review the...
