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A case of treatment-resistant advanced gastric cancer with FGFR2 gene alteration successfully treated with pemigatinib
Comprehensive genome profiling (CGP) is expected to widen the scope of cancer drug options by identifying the genes involved in carcinogenesis....
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Neuropathy severity at the time of oxaliplatin treatment alteration in patients with colon cancer (Alliance A151912)
BackgroundClinical guidelines recommend altering chemotherapy treatment by decreasing, delaying, or discontinuing dosing in patients who are...
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A taste alteration-related scale assesses megestrol to improve chemotherapy-induced anorexia
PurposeWe evaluated the efficacy of megestrol in improving chemotherapy-related anorexia by analyzing the related scales of taste alteration.
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Alteration of Plasma Indoles in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in reproductive-aged women. The occurrence of PCOS was reported to be...
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N-methyl-D-aspartate receptors and thymoquinone induce apoptosis and alteration in mitochondria in colorectal cancer cells
Colon cancer is on the rise in both men and women. In addition to traditional treatment methods, herbal treatments from complementary and alternative...
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Management and Treatment of Non-small Cell Lung Cancer with MET Alteration and Mechanisms of Resistance
MET-driven tumors are a heterogenous group of non-small cell lung cancers (NSCLC) with activating mutations. Pathologic activation of MET can be...
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The interaction between klotho protein and epigenetic alteration in diabetes and treatment options
IntroductionKlotho is a membrane protein predominantly expressed in the kidneys, and its discovery was serendipitously made through gene-targeting...
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Retinal neurovascular alteration in type 2 diabetes with renal impairment in association with systemic arterial stiffness
BackgroundDiabetic retinopathy (DR) patients should be alert for subclinical macroangiopathy. We aimed to investigate the association between retinal...
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Somatic copy number alteration and fragmentation analysis in circulating tumor DNA for cancer screening and treatment monitoring in colorectal cancer patients
BackgroundAnalysis of circulating free DNA (cfDNA) is a promising tool for personalized management of colorectal cancer (CRC) patients. Untargeted...
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Experimental congenital diaphragmatic hernia features an alteration of DNA sensing targets cGAS and STING
BackgroundThe pathogenesis of congenital diaphragmatic hernia (CDH) depends on multiple factors. Activation of the DNA-sensing...
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Sacubitril/valsartan mitigated intermittent hypoxia related intestinal microbiota alteration and aortic injury
ObjectiveTo investigate the influence of sacubitril valsartan sodium (SVS) on chronic intermittent hypoxia (IH) related gut microbiome composition...
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Machine learning on MRI radiomic features: identification of molecular subtype alteration in breast cancer after neoadjuvant therapy
ObjectivesRecent studies have revealed the change of molecular subtypes in breast cancer (BC) after neoadjuvant therapy (NAT). This study aims to...
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Repeated inflammatory dural stimulation-induced cephalic allodynia causes alteration of gut microbial composition in rats
BackgroundGut microbial dysbiosis and gut-brain axis dysfunction have been implicated in the pathophysiology of migraine. However, it is unclear...
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Alteration in Gut Microbiota Composition of Older Adults Is Associated with Obesity and Its Indices: A Systematic Review
BackgroundObesity in the older adults is a health concern that increases the risk of several life-threatening diseases. Previous research has been...
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Alteration of PD-L1 (SP142) status after neoadjuvant chemotherapy and its clinical significance in triple-negative breast cancer
PurposeThe tumor immune microenvironment can change after neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC). We aimed to...
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Impact of radiation dose on patient-reported acute taste alteration in a prospective observational study cohort in head and neck squamous cell cancer (HNSCC)
PurposeTaste alteration (TA) is a frequent acute side effect of radiation treatment in HNSCC patients. Principal aim of our study was to investigate...
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Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome
BackgroundMechanisms underpinning ARDS induced by COVID-19 are mostly immune-mediated, but need to be completely clarified. This study aimed to...
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Alpha-lipoic acid induced apoptosis of PC3 prostate cancer cells through an alteration on mitochondrial membrane depolarization and MMP-9 mRNA expression
Cancer has become an important cause of mortality and morbidity in the world. Over the past decades, biomedical research revealed insights into the...
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Pediatric spinal cord diffuse midline glioma with H3 K27M-alteration with leptomeningeal dissemination: a rare case with intracranial hypertension onset and no spinal cord-related symptom
PurposeSpinal cord diffuse midline glioma (DMG) with H3 K27-alteration is a group of spinal cord high-grade glioma with poor outcome. We present a...
