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The role of transforming growth factor-β (TGF-β) in the formation of exhausted CD8 + T cells
CD8 + T cells exert a critical role in eliminating cancers and chronic infections, and can provide long-term protective immunity. However, under the...
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Anlotinib Attenuates Liver Fibrosis by Regulating the Transforming Growth Factor β1/Smad3 Signaling Pathway
BackgroundHepatic stellate cell hyperactivation is a central link in liver fibrosis development, transforming growth factor β 1 (TGF- β 1) is a key...
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Association of serum transforming growth factor β1 with left ventricular hypertrophy in children with primary hypertension
The current study was designed to assess the association of serum transforming growth factor β 1 (TGF-β 1 ) with left ventricular hypertrophy (LVH) in...
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Transforming growth factor-β in myocardial disease
Transforming growth factor-β (TGFβ) isoforms are upregulated and activated in myocardial diseases and have an important role in cardiac repair and...
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Dominant-negative transforming growth factor-β receptor-armoured mesothelin-targeted chimeric antigen receptor T cells slow tumour growth in a mouse model of ovarian cancer
Ovarian cancer is a major cause of death among all gynaecological cancers. Although surgery, chemotherapy and targeted therapy have yielded...
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Cord blood transforming growth factor-β-induced as predictive biomarker of retinopathy of prematurity in preterm infants
PurposeTo determine whether 14 inflammation-, angiogenesis-, and adhesion-related proteins in cord blood (CB), alone or in combination with...
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Peripheral Treg Levels and Transforming Growth Factor-β (TGFβ) in Patients with Psoriatic Arthritis: A Systematic Review Meta-Analysis
IntroductionStudies on the level of regulatory T (T reg ) cells in psoriatic arthritis (PsA) have been controversial, leading to disagreement...
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Upregulated expression of transforming growth factor-β receptor I/II in an endemic Osteoarthropathy in China
BackgroundKashin–Beck disease (KBD) is a chronic, deforming, endemic osteochondropathy that begins in patients as young as 2–3 years of age. The...
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TRPV2 Promotes Cell Migration and Invasion in Gastric Cancer via the Transforming Growth Factor-β Signaling Pathway
BackgroundTransient receptor potential vanilloid 2 (TRPV2) is a highly Ca 2+ -permeable ion channel that is involved in a number of cellular...
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Role of transforming growth factor beta in assessment of severity of hypersensitivity pneumonitis: a single center study
BackgroundHypersensitivity pneumonitis (HP) is a more frequently diagnosed picture of diffuse parenchymal lung disease. It is an inflammation of the...
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The role of transforming growth factor beta in bicuspid aortic valve aortopathy
A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac deformity, which is associated with an increased risk to develop a thoracic...
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Hydrogen peroxide enhances transforming growth factor beta-2 induced epithelial–mesenchymal transition of ARPE-19 cells
BackgroundIn the pathophysiology of the retina, the epithelial–mesenchymal transition and oxidative stress play key roles. To find a relationship...
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The Role of Latent Transforming Growth Factor β Binding Protein 2 (LTBP2) in the Diagnosis and Stage Discrimination of Gastric Cancer
Gastric cancer is a major health problem all over the world. In this study, it is aimed to investigate the effect of Latent Transforming Growth...
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Expression of Epidermal Growth Factor Receptor (EGFR) and β-catenin in Colorectal Carcinoma and its Correlation with Tumor Grade and Stage
Colorectal cancer (CRC) is considered the result of the cumulative effect of multiple mutations within the cell that allow it to escape growth...
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Involvement of Interleukin-1 β/Insulin-Like Growth Factor 1 in Ameliorating Effects of Electroacupuncture on Myocardial Fibrosis Induced by Essential Hypertension
ObjectiveTo investigate the effect of electroacupuncture (EA) at Neiguan (PC 6) on myocardial fibrosis in spontaneously hypertensive rats (SHRs), and...
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Clinical significance of the expression levels of serum transforming growth factor-β and CXC type chemokine ligand 13 in primary Sjogren’s syndrome patients
ObjectiveThe aim of this study was to investigate the expression levels of the serum transforming growth factor-β1 (TGF-β1) CXC type chemokine ligand...
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Transforming Growth Factor-β and the Renin-Angiotensin System in Syndromic Thoracic Aortic Aneurysms: Implications for Treatment
Thoracic aortic aneurysms (TAAs) are permanent pathological dilatations of the thoracic aorta, which can lead to life-threatening complications, such...
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Impact of Melatonin on Full-Term Fetal Brain Development and Transforming Growth Factor-β Level in a Rat Model of Preeclampsia
Preeclampsia (PE) is a leading cause of stroke and cognitive impairment in the offspring. Melatonin is involved in the outcome of normal pregnancy....
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The relationship between transforming growth factor β superfamily members (GDF11 and BMP4) and lumbar spine bone mineral density in postmenopausal Chinese women
PurposeThe relationship between transforming growth factor β superfamily members (GDF11 and BMP4) and bone metabolism remains controversial. The aim...
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Transforming growth factor-induced gene TGFBI is correlated with the prognosis and immune infiltrations of breast cancer
BackgroundTransforming growth factor β (TGFβ) is a critical regulator of lung metastasis of breast cancer and is correlated with the prognosis of...