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Therapeutic efficacy of voltage-gated sodium channel inhibitors in epilepsy
Epilepsy is a neurological disease characterized by excessive and abnormal hyper-synchrony of electrical discharges of the brain and a predisposition...
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Targeting BCAA metabolism to potentiate metformin’s therapeutic efficacy in the treatment of diabetes in mice
Aims/hypothesisAn increasing body of evidence has shown that the catabolism of branched-chain amino acids (BCAAs; leucine, isoleucine and valine) is...
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Safety and efficacy of therapeutic hypothermia in neonates with mild hypoxic-ischemic encephalopathy
BackgroundThough there has been an increase in the number of neonates with hypoxic-ischemic encephalopathy (HIE) treated by therapeutic hypothermia...
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Phenotype-specific therapeutic efficacy of ilofotase alfa in patients with sepsis-associated acute kidney injury
BackgroundThere is no effective treatment for sepsis-associated acute kidney injury (SA-AKI). Ilofotase alfa (human recombinant alkaline phosphatase)...
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Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy
Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in human health. An altered microbiome can be...
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A meta-analysis on the therapeutic efficacy of repetitive transcranial magnetic stimulation for cognitive functions in attention-deficit/hyperactivity disorders
BackgroundTherapeutic efficacies of repetitive transcranial magnetic stimulation (rTMS) for improving cognitive functions in patients with...
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Nanobody-based trispecific T cell engager (Nb-TriTE) enhances therapeutic efficacy by overcoming tumor-mediated immunosuppression
BackgroundT cell engagers (TCEs) have been established as an emerging modality for hematologic malignancies, but solid tumors remain refractory....
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Efficacy of RCI001 as a therapeutic candidate of dry eye disease in a modified mixed dry eye model
BackgroundTo evaluate the therapeutic effects of topical RCI001 (RCI) and compare its efficacy with that of 1% prednisolone acetate (PDE) and 5%...
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Preventing mental illness in children that experienced maltreatment the efficacy of REThink online therapeutic game
Exposure to child maltreatment (CM) is considered to predispose children to devastating consequences in terms of mental health. Thus, it is a public...
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The Therapeutic Alliance as Active Inference: The Role of Trust and Self-Efficacy
The therapeutic alliance has a robust association with positive outcome in psychotherapy. It is considered a common factor of change independent of...
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Efficacy of washed microbiota transplantation for therapeutic targets of refractory functional constipation and the influencing factors: a single-center, retrospective, 24-week follow-up study
BackgroundThe efficacy of washed microbiota transplantation (WMT) in terms of refractory functional constipation (FC)-related therapeutic targets and...
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Therapeutic efficacy of gut microbiota-derived polyphenol metabolite Urolithin A
BackgroundDespite rising public awareness and improvements in diagnostic and treatment methods, there are adverse effects brought on by drug...
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Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury
BackgroundPerinatal brain injury is multifactorial and primarily associated with brain prematurity, inflammation, and hypoxia–ischemia. Although...
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Age and mean platelet volume-based nomogram for predicting the therapeutic efficacy of metoprolol in Chinese pediatric patients with vasovagal syncope
BackgroundVasovagal syncope (VVS) is the most common type of orthostatic intolerance in children. We investigated whether platelet-related factors...
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Integrated Safety and Efficacy Analyses of Phase 3 Trials of a Microbiome Therapeutic for Recurrent CDI
IntroductionRecurrent Clostridioides difficile infection (rCDI) often occurs after standard-of-care antibiotics. VOWST oral spores (VOS, previously...
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Therapeutic efficacy of tranexamic acid on traumatic brain injury: a systematic review and meta-analysis
ObjectiveTranexamic acid (TXA) demonstrates therapeutic efficacy in the management of traumatic brain injury (TBI). The objective of this systematic...
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Therapeutic efficacy evaluation of Tuina at points on abdomen and back meridians for infantile colic
ObjectiveTo evaluate the efficacy of Tuina (Chinese therapeutic massage) at points on abdomen and back meridians in the treatment of infantile colic.
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Brain stimulation for patients with multiple sclerosis: an umbrella review of therapeutic efficacy
Multiple sclerosis patients often experience various symptoms that can greatly impact their quality of life. There are various brain stimulation...
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Systematic review of aquatic therapeutic exercise efficacy in breast cancer survivors
PurposeThe aim of this review is to establish the efficacy of aquatic therapeutic exercise in female breast cancer survivors for improving fatigue,...
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The Balance Between the Therapeutic Efficacy and Safety of [177Lu]Lu-NeoB in a Preclinical Prostate Cancer Model
PurposeRadiolabeled NeoB is a promising gastrin-releasing peptide receptor (GRPR)–targeting radiopharmaceutical for theranostics of GRPR-expressing...
