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Survival paradox between stage IIB/C and stage IIIA colon cancer: is it time to revise the American Joint Committee on Cancer TNM system?
IntroductionA survival paradox between T4N0 (Stage IIB/IIC) and Stage IIIA colon cancer exists, even after adjusting for adequate lymph node (LN)...
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Novel prediction model combining PET/CT metabolic parameters, inflammation markers, and TNM stage: prospects for personalizing prognosis in nasopharyngeal carcinoma
PurposeThis study aims to develop a novel prediction model and risk stratification system that could accurately predict progression-free survival...
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CINSARC signature outperforms gold-standard TNM staging and consensus molecular subtypes for clinical outcome in stage II–III colorectal carcinoma
The outcome of stage II–III colorectal cancer (CRC) is highly variable and therapeutic choice is currently based on TNM staging with a few additional...
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Prognostic Significance of the Maximum Standardized Uptake Value on the Prognosis of Clinical Stage IA Lung Adenocarcinoma Based on the 8th Edition TNM Classification
BackgroundThere are few reports on the utility of the maximum standardized uptake value (SUVmax) for predicting the prognosis of early-stage lung...
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Combining nutritional status with TNM stage: a physiological update on gastric cancer staging for improving prognostic accuracy in elderly patients
BackgroundThe tumor-node-metastasis (TNM) staging system does not take the patient’s physiological status into consideration, reportedly making it...
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Pee** Beyond TNM Stage: Prognostic Factors Affecting Oncological Outcomes in Surgically Treated Early Oral Cancer
Surgery is the primary modality for the treatment of early oral cancer. The present study aims to evaluate the oncological outcomes, patterns of...
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CT-based radiomics stratification of tumor grade and TNM stage of clear cell renal cell carcinoma
ObjectivesTo evaluate the utility of CT-based radiomics signatures in discriminating low-grade (grades 1–2) clear cell renal cell carcinomas (ccRCC)...
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Validation of the TNM-8 AJCC classification for HPV-positive oropharyngeal cancers in patients undergoing trans-oral robotic surgery
High-risk human papillomaviruses (HPV) are associated with some oropharyngeal squamous cell carcinomas (OPSCC). HPV-OPSCC have better survival...
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Routine contrast-enhanced CT is insufficient for TNM-staging of duodenal adenocarcinoma
PurposeAdequate TNM-staging is important to determine prognosis and treatment planning of duodenal adenocarcinoma. Although current guidelines advise...
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Decoding tumor stage by peritumoral and intratumoral radiomics in resectable esophageal squamous cell carcinoma
PurposeTo evaluate the potential application of radiomics in predicting Tumor-Node-Metastasis (TNM) stage in patients with resectable esophageal...
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Head and neck MRI-based T stage and [18F]FDG PET/CT-based N/M stage improved prognostic stratification in primary nasopharyngeal carcinoma
ObjectivesTo evaluate whether MRI-based T stage (T MRI ), [ 18 F]FDG PET/CT-based N (N PET/CT ), and M stage (M PET/CT ) are superior in NPC patients’...
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Evolution of TNM Classification for Clinical Staging of Oral Cancer: The Past, Present and the Future
PurposeThe AJCC (American Joint Committee on Cancer) Cancer Staging Manual, 1st Edition, was published in 1977 which focused on the TNM...
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Lymph node ratio is a more robust predictor of overall survival than N stage in stage III colorectal adenocarcinoma
BackgroundLymph node ratio (LNR) may offer superior prognostic stratification in colorectal adenocarcinoma compared with N stage. However, candidate...
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Inclusion of Perineural Invasion with AJCC-TNM Staging: Outcomes from a South Asian Cohort of Curatively Treated Gastric Cancer Patients
BackgroundThe incidence of perineural invasion (PNI) in patients with gastric cancer (GC) is high, and patients with PNI positive disease have a poor...
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Nationwide Validation of the 8th American Joint Committee on Cancer TNM Staging System and Five Proposed Modifications for Resected Pancreatic Cancer
BackgroundThe prognostic value of four proposed modifications to the 8th American Joint Committee on Cancer (AJCC) TNM staging system has yet to be...
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Impact of 18F-FDG PET on TNM Staging and Prognosis in Thymic Epithelial Tumors
BackgroundPreoperative fluorine-18-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) of thymic epithelial tumors (TETs) is well known...
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Stage II colon cancer staging using the number of retrieved lymph nodes may be superior to current TNM staging for prognosis stratification: the Japanese study group for postoperative follow-up of colorectal cancer
PurposeThe purpose of the study was to compare staging of stage II colon cancer using the number of retrieved lymph nodes (RN) to current TNM staging...
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The significance of regular chest computed tomography in postoperative surveillance for surgically resected non-small cell lung cancer based on TNM 8th staging system
ObjectivesAlthough several societies recommend regular chest computed tomography (CT) scans for the surveillance of surgically resected non-small...
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Outcome of radical surgery for gallbladder carcinoma according to TNM stage: implications for adjuvant therapeutic strategies
PurposeOutcomes following surgery for advanced gallbladder carcinoma remain unsatisfactory. This study aimed to determine the surgical outcome and...
