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TMPRSS4 is a novel biomarker and correlated with immune infiltration in thyroid carcinoma
Transmembrane protease serine 4 (TMPRSS4) is a cancer-associated protease associated with prognosis in various types of cancer. Mechanistically,...
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Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer
BackgroundTransmembrane serine protease 4 (TMPRSS4) belongs to the family of type II transmembrane serine proteases that are known to be upregulated...
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Effects of transmembrane serine protease 4 on the survival in patients with pancreatic ductal adenocarcinoma undergoing surgery followed by adjuvant chemotherapy
PurposeThe transmembrane serine protease 4 (TMPRSS4) gene is upregulated in various human cancers. However, its biological functions in pancreatic...
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Data-Driven Identification of Targets for Fluorescence-Guided Surgery in Non-Small Cell Lung Cancer
PurposeIntraoperative identification of lung tumors can be challenging. Tumor-targeted fluorescence-guided surgery can provide surgeons with a tool...
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Machine learning reveals diverse cell death patterns in lung adenocarcinoma prognosis and therapy
Cancer cell growth, metastasis, and drug resistance pose significant challenges in the management of lung adenocarcinoma (LUAD). However, there is a...
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Dysregulation of COVID-19 related gene expression in the COPD lung
BackgroundChronic obstructive pulmonary disease (COPD) patients are at increased risk of poor outcome from Coronavirus disease (COVID-19). Early data...
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A comprehensive analysis of different gene classes in pancreatic cancer: SIGLEC15 may be a promising immunotherapeutic target
Background . Pancreatic cancer (PC) is one of the most lethal cancer types with an extremely poor diagnosis and prognosis. This study aimed to...
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A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation
BackgroundCompound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the...
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Robust and consistent biomarker candidates identification by a machine learning approach applied to pancreatic ductal adenocarcinoma metastasis
BackgroundMachine Learning (ML) plays a crucial role in biomedical research. Nevertheless, it still has limitations in data integration and...
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Expression map of entry receptors and infectivity factors for pan-coronaviruses in preimplantation and implantation stage human embryos
PurposeTo predict if develo** human embryos are permissive to multiple coronaviruses.
MethodWe analyzed publicly available single-cell RNA-seq...
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Genetic susceptibility of COVID-19: a systematic review of current evidence
IntroductionWhile COVID-19 pandemic continues to spread worldwide, researchers have linked patterns of traits to poor disease outcomes. Risk factors...
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Schilddrüse und SARS-CoV-2
There are several interactions between a SARS-CoV‑2 infection and the thyroid, bidirectionally in both directions. In severe COVID-19 infection,...
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Bioinformatics Analysis Reveals Novel Differentially Expressed Genes Between Ectopic and Eutopic Endometrium in Women with Endometriosis
BackgroundEndometriosis is one of the chronic and prevalent diseases among women. There is limited knowledge about its pathophysiology at the...
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Matriptase as a potential biomarker and therapeutic target in newly diagnosed type 2 diabetes mellitus
BackgroundType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that affects the processing of carbohydrates, proteins, and lipids. In...
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In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation
ObjectiveTo explore potential natural products against severe acute respiratory syndrome coronavirus (SARS-CoV-2) via the study of structural and...
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COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms
Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is spreading globally...
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Ferroptosis-related genes prognostic signature for pancreatic cancer and immune infiltration: potential biomarkers for predicting overall survival
BackgroundPancreatic adenocarcinoma (PAAD) constitutes a lethal malignancy, notorious for its elevated mortality rates due to the difficulties in...
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SARS-CoV-2 and the next generations: which impact on reproductive tissues?
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is a severe global pandemic, affecting...
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Epitope Analysis of Anti-SARS-CoV-2 Neutralizing Antibodies
Coronavirus disease 2019 is threatening thousands of millions of people around the world. In the absence of specific and highly effective medicines,...
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Design and evaluation of a multiepitope vaccine for pancreatic cancer using immune-dominant epitopes derived from the signature proteome in expression datasets
Pancreatic cancer is a highly aggressive and often lethal malignancy with limited treatment options. Its late-stage diagnosis and resistance to...
