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1. The β-catenin/TCF-4 pathway regulates the expression of OPN in human osteoarthritic chondrocytes

   Background

   Cartilage destruction is the main characteristic of osteoarthritis (OA), and osteopontin (OPN) is elevated in OA articular cartilage;...

   Jian Tian, Shu-Guang Gao, ... Fang-Jie Zhang in Journal of Orthopaedic Surgery and Research

   Article Open access 20 August 2020
   

2. The β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis

   Hepatocellular carcinoma (HCC) metastasis is largely responsible for HCC-associated recurrence and mortality. We aimed to identify metastasis-related...

   Wei-Juan Huang, **ao-Peng Tian, ... Mei Li in Oncogene

   Article Open access 05 May 2020
   

3. Hydrogen sulfide suppresses H₂O₂-induced proliferation and migration of HepG2 cells through Wnt/β-catenin signaling pathway

   Both H ₂ S and H ₂ O ₂ affect many cellular events, such as cell differentiation, cell proliferation and cell death. However, there is some controversy...

   Hongzhi Zhao, Liang Zhao, ... Wei Zhao in Medical Oncology

   Article 28 June 2023
   

4. Resveratrol nanoparticles induce apoptosis in oral cancer stem cells by disrupting the interaction between β-catenin and GLI-1 through p53-independent activation of p21

   Cancer stem cells (CSCs) are mainly responsible for tumorigenesis, chemoresistance, and cancer recurrence. CSCs growth and progression are regulated...

   Subhasmita Bhal, Biswajit Das, ... Chanakya Nath Kundu in Medical Oncology

   Article 04 June 2024
   

5. Fibulin-3 sponges Tiam1 to manipulate MMP-7 activity through β-catenin signaling in oral squamous cell carcinoma

   Oral squamous cell carcinoma (named OSCC) is considered the most frequent malignancy in oral cavity, which has become a rapid increasing problem for...

   Honglei Guo, Yangyang Ji, ... **n Huang in Medical Oncology

   Article 19 July 2022
   

6. Astragalus membranaceus (Huangqi) and Rhizoma curcumae (Ezhu) decoction suppresses colorectal cancer via downregulation of Wnt5/β-Catenin signal

   Background

   The decoction of Astragalus membranaceus (Huangqi) and Rhizoma curcumae (Ezhu) has been reported as a potential antitumor agent for...

   Yong Bian, Gang Wang, ... Yun Yu in Chinese Medicine

   Article Open access 06 January 2022
   

7. RUNX3 inhibits glioma survival and invasion via suppression of the β-catenin/TCF-4 signaling pathway

   Introduction

   Runt-related transcription factor 3 (RUNX3) exerts a tumor suppressor gene associated with gastric and other cancers, including glioma....

   Jikui Sun, Banban Li, ... Weidong Yang in Journal of Neuro-Oncology

   Article 18 June 2018
   

8. Digital counting of tissue cells for molecular analysis: the QuANTUM pipeline

   The estimation of tumor cellular fraction (TCF) is a crucial step in predictive molecular pathology, representing an entry adequacy criterion also in...

   Vincenzo L’Imperio, Giorgio Cazzaniga, ... Fabio Pagni in Virchows Archiv

   Article Open access 26 March 2024
   

9. Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow

   Purpose

   Although pediatric low-grade gliomas (pLGG) are the most common pediatric brain tumors, patient-derived cell lines reflecting pLGG biology in...

   Florian Selt, Ahmed El Damaty, ... Till Milde in Journal of Neuro-Oncology

   Article Open access 24 November 2023
   

10. Safety evaluation of a stepwise tracheostomy decannulation program in pediatric patients

    Purpose

    In the event of failed tracheostomy decannulation, patients might have a tragic course of events. We retrospectively evaluated our stepwise...

    Juma Obayashi, Koji Fukumoto, ... Takafumi Tsukui in Pediatric Surgery International

    Article 02 September 2023
    

11. Closing the Gap: Exploring the Role of Cap Grafts in Tracheocutaneous Fistula Closure

    Exploring the Role of Cap Grafts in tracheocutaneous fistula Closure. A tracheocutaneous fistula (TCF) is an abnormal connection that forms between...

    T. B. Shashidhar, Karthik Balakrishnan, Indresh Chandra in Indian Journal of Otolaryngology and Head & Neck Surgery

    Article 19 March 2024
    

12. Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy

    T cell differentiation is a highly regulated, multi-step process necessary for the progressive establishment of effector functions, immunological...

    Yannick Bulliard, Borje S. Andersson, ... Apostolia M. Tsimberidou in Journal of Hematology & Oncology

    Article Open access 25 October 2023
    

13. TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responses

    Abstract

    Cancer immunotherapy relies on improving T cell effector functions against malignancies, but despite the identification of several key...

    Rebecca Harris, Mahinbanu Mammadli, ... Mobin Karimi in Cancer Immunology, Immunotherapy

    Article Open access 23 December 2022
    

14. ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization

    Background

    Multitarget tyrosine kinase inhibitors (mTKIs) such as Regorafenib and Sorafenib have already been approved for the treatment of many solid...

    **aolin Lu, Ruiqi Liu, ... Yanqiao Zhang in BMC Medicine

    Article Open access 25 September 2023
    

15. Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy

    The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development, tissue homeostasis, and cell...

    Pan Song, Zirui Gao, ... **awei Wei in Journal of Hematology & Oncology

    Article Open access 18 June 2024
    

16. Kaempferol prevents aseptic loosening via enhance the Wnt/β-catenin signaling pathway in vitro and in vivo

    Kaempferol has demonstrated notable positive effects on the osteogenic differentiation of mesenchymal stem cells (MSC) and osteoblasts. A substantial...

    Wenkui Qiu, Zhenghui Li, ... Yanqing Li in European Journal of Medical Research

    Article Open access 09 November 2023
    

17. Occlusive Tight Strap** for Tracheostomy Decannulation; Is it Safe?

    Decannulation following tracheostomy is an important transition. Subcutaneous emphysema (SE) following decannulation has been rarely reported. We,...

    Geetanjali Tolia Chilkoti, Nikita Mary Mundakel, ... Vipin Arora in Indian Journal of Otolaryngology and Head & Neck Surgery

    Article 29 April 2024
    

18. Enhanced anticancer synergy of LOM612 in combination with selinexor: FOXO1 nuclear translocation-mediated inhibition of Wnt/β-catenin signaling pathway in breast cancer

    Background

    The intricate relationship between Forkhead box O1 (FOXO1), a well-established tumor suppressor, and breast cancer (BC) remains partially...

    Shengxi Xu, Yingfang Shi, Sen Li in Cancer Chemotherapy and Pharmacology

    Article 05 December 2023
    

19. T cells in health and disease

    T cells are crucial for immune functions to maintain health and prevent disease. T cell development occurs in a stepwise process in the thymus and...

    Lina Sun, Yanhong Su, ... Baojun Zhang in Signal Transduction and Targeted Therapy

    Article Open access 19 June 2023
    

20. The WNT/β-catenin system in chronic kidney disease-mineral bone disorder syndrome

    Background

    The WNT/β-catenin system is an evolutionarily conserved signaling pathway that plays a crucial role in morphogenesis and cell tissue...

    Lingbo Zhang, Isaac Kumi Adu, ... Jiancheng Wang in International Urology and Nephrology

    Article 24 March 2023