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Super-resolution neural networks improve the spatiotemporal resolution of adaptive MRI-guided radiation therapy
BackgroundMagnetic resonance imaging (MRI) offers superb non-invasive, soft tissue imaging of the human body. However, extensive data sampling...
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A Review of Clinical Applications for Super-resolution Ultrasound Localization Microscopy
Microvascular structure and hemodynamics are important indicators for the diagnosis and assessment of many diseases and pathologies. The structural...
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Super-resolution ultrasound and microvasculomics: a consensus statement
AbstractThis is a summary of a consensus statement on the introduction of “Ultrasound microvasculomics” produced by The Chinese Artificial...
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Cerebral organoids with chromosome 21 trisomy secrete Alzheimer’s disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy
Understanding the role of small, soluble aggregates of beta-amyloid (Aβ) and tau in Alzheimer’s disease (AD) is of great importance for the rational...
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Imaging of spine synapses using super-resolution microscopy
Neuronal circuits in the neocortex and hippocampus are essential for higher brain functions such as motor learning and spatial memory. In the...
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Rapid microscopic 3D-diffusion tensor imaging fiber-tracking of mouse brain in vivo by super resolution reconstruction: validation on MAP6-KO mouse model
ObjectExploring mouse brains by rapid 3D-Diffusion Tensor Imaging (3D-DTI) of high spatial resolution (HSR) is challenging in vivo . Here we use the...
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Quantitative volumetric analysis of the Golgi apparatus following X-ray irradiation by super-resolution 3D-SIM microscopy
To obtain quantitative volumetric data for the Golgi apparatus after ionizing radiation (IR) using super-resolution three-dimensional structured...
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Principles of microscopy for ophthalmologists
This short review begins with the theories of Airy, Rayleigh and Abbe on microscope resolution. Next, the principal developments in microscopy in the...
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Projective oblique plane structured illumination microscopy
Structured illumination microscopy (SIM) can double the spatial resolution of a fluorescence microscope and video rate live cell imaging in a...
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Clinical application of the HM-1000 image processing for HER2 fluorescence in situ hybridization signal quantification in breast cancer
BackgroundAccurate quantification of human epidermal growth factor receptor 2 ( HER2 ) gene amplification is important for predicting treatment...
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Combined expansion and STED microscopy reveals altered fingerprints of postsynaptic nanostructure across brain regions in ASD-related SHANK3-deficiency
Synaptic dysfunction is a key feature of SHANK-associated disorders such as autism spectrum disorder, schizophrenia, and Phelan-McDermid syndrome....
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Digital in-line holographic microscopy for label-free identification and tracking of biological cells
Digital in-line holographic microscopy (DIHM) is a non-invasive, real-time, label-free technique that captures three-dimensional (3D) positional,...
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Advances in fluorescence microscopy techniques to study kidney function
Fluorescence microscopy, in particular immunofluorescence microscopy, has been used extensively for the assessment of kidney function and pathology...
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Electron microscopy of cardiac 3D nanodynamics: form, function, future
The 3D nanostructure of the heart, its dynamic deformation during cycles of contraction and relaxation, and the effects of this deformation on cell...
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Phagocytosis model of calcium oxalate monohydrate crystals generated using human induced pluripotent stem cell-derived macrophages
Macrophages play a role in nephrolithiasis, offering the possibility of develo** macrophage-mediated preventive therapies. To establish a system...
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Activation of multiple Eph receptors on neuronal membranes correlates with the onset of optic neuropathy
BackgroundOptic neuropathy is a major cause of irreversible blindness, yet the molecular determinants that contribute to neuronal demise have not...
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A hyper-resolving polynomial aperture and its application in microscopy
BackgroundA hyper-resolving aperture composed of a polynomial distribution is suggested. The point spread function (PSF) is computed and compared...
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PFA is superior to glyoxal in preserving oocyte, embryo, and stem cell proteins evidenced by super-resolution microscopical surveys of epitopes
PurposeChemical fixation is a critical step to retaining cellular targets as naturally as possible. Recent developments in microscopy allow...
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Three-dimensional ultrastructure analysis of organelles in injured motor neuron
Morphological analysis of organelles is one of the important clues for understanding the cellular conditions and mechanisms occurring in cells. In...
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Selective vulnerability of tripartite synapses in amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder. Separate lines of evidence suggest that synapses and astrocytes play a...
