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  1. Ablation of Kidney Tumors in Patients with Substantial Kidney Impairment: Current Status

    Purpose of review

    To review the current status of kidney tumor ablation in patients with substantial kidney impairment.

    Recent findings ...
    Toshihiro Iguchi, Yusuke Matsui, ... Takao Hiraki in Current Oncology Reports
    Article 16 April 2024
  2. Substantial but spatially heterogeneous progress in male circumcision for HIV prevention in South Africa

    Background

    Voluntary medical male circumcision (VMMC) reduces the risk of male HIV acquisition by 60%. Programmes to provide VMMCs for HIV prevention...

    Matthew L. Thomas, Khangelani Zuma, ... Jeffrey W. Imai-Eaton in Communications Medicine
    Article Open access 03 January 2024
  3. Knees with anteromedial osteoarthritis show a substantial phenotypic variation prior and following medial unicompartmental knee arthroplasty

    Purpose

    The primary aim of this study was to evaluate the phenotypic variation using the Coronal Plane Alignment of the Knee (CPAK) classification...

    G. V. ten Noever de Brauw, T. Bayoumi, ... H. A. Zuiderbaan in Knee Surgery, Sports Traumatology, Arthroscopy
    Article 17 October 2023
  4. Substantial influence of psychological factors on return to sports after anterior shoulder instability surgery: a systematic review and meta-analysis

    Purpose

    This systematic review and meta-analysis aimed to (1) determine the proportion of patients who underwent anterior shoulder instability surgery...

    Ausberto Velasquez Garcia, Naoya Iida, ... Max Ekdahl in Knee Surgery, Sports Traumatology, Arthroscopy
    Article 22 November 2023
  5. Minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) in patients who have undergone total knee arthroplasty: a systematic review

    Background

    The present systematic review investigated the minimal clinically important difference (MCID), substantial clinical benefit (SCB), and...

    Filippo Migliorini, Nicola Maffulli, ... Ulf Krister Hofmann in Knee Surgery & Related Research
    Article Open access 11 January 2024
  6. Exploring the feasibility of using the ICER Evidence Rating Matrix for Comparative Clinical Effectiveness in assessing treatment benefit and certainty in the clinical evidence on orphan therapies for paediatric indications

    Background

    The evaluation of clinical evidence takes account of health benefit (efficacy and safety) and the degree of certainty in the estimate of...

    Jaro Wex, Monika Szkultecka-Debek, ... Natasa Zibelnik in Orphanet Journal of Rare Diseases
    Article Open access 20 July 2023
  7. Liver fibrosis indices associated with substantial hematoma expansion in Chinese patients with primary intracerebral hemorrhage

    Background

    Whether liver fibrosis is associated with increased risk for substantial hematoma expansion (HE) after intracerebral hemorrhage (ICH) is...

    Huan Wang, Jiongxing Wu, ... Deren Wang in BMC Neurology
    Article Open access 09 December 2021
  8. Low rate of substantial loss of reduction immediately after hardware removal following acromioclavicular joint stabilization using a suspensory fixation system

    Purpose

    To evaluate immediate loss of reduction in patients undergoing hardware removal after arthroscopically assisted acromioclavicular (AC) joint...

    Marco-Christopher Rupp, Pavel M. Kadantsev, ... Daniel P. Berthold in Knee Surgery, Sports Traumatology, Arthroscopy
    Article Open access 22 April 2022
  9. Custom TKA combined with personalised coronal alignment yield improvements that exceed KSS substantial clinical benefits

    Purpose

    The purpose of this study was to report Knee Society Scores (KSS) at 12-month follow-up in a series of 266 knees that received custom TKA. The...

    Salvatore Ratano, Jacobus H. Müller, ... Michel P. Bonnin in Knee Surgery, Sports Traumatology, Arthroscopy
    Article 18 February 2022
  10. Minimal clinically important difference (MCID) and substantial clinical benefit (SCB) of upper extremity PROMIS scores following arthroscopic rotator cuff repairs

    Purpose

    To calculate and determine what factors are associated with achieving the Minimal Clinically Important Difference (MCID) and the Substantial...

    Matthew G. Alben, Dan Gordon, ... Mandeep S. Virk in Knee Surgery, Sports Traumatology, Arthroscopy
    Article 09 January 2023
  11. The “Gateway” hypothesis: evaluation of evidence and alternative explanations

    Background

    Electronic nicotine delivery systems (ENDS) offer a substantial harm reduction opportunity for adults who smoke and are unlikely to quit....

    Arielle Selya in Harm Reduction Journal
    Article Open access 07 June 2024
  12. Real-world evidence for coverage determination of treatments for rare diseases

    Health technology assessment (HTA) decisions for pharmaceuticals are complex and evolving. New rare disease treatments are often approved more...

    Victoria W. Dayer, Michael F. Drummond, ... Sean D. Sullivan in Orphanet Journal of Rare Diseases
    Article Open access 07 February 2024
  13. Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy

    The immune response against cancer is orchestrated by various parameters and site-dependent specificities have been poorly investigated. In our...

    Martin Thelen, Kerstin Wennhold, ... Hans A. Schlößer in npj Precision Oncology
    Article Open access 16 June 2021
  14. Substantial health and economic burden of COVID-19 during the year after acute illness among US adults at high risk of severe COVID-19

    Background

    Post-COVID conditions encompass a range of long-term symptoms after SARS-CoV-2 infection. The potential clinical and economic burden in the...

    Amie Scott, Wajeeha Ansari, ... Jessica E. Atwell in BMC Medicine
    Article Open access 01 February 2024
  15. Minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient acceptable symptomatic state (PASS) of upper extremity PROMIS scores in idiopathic adhesive capsulitis

    Introduction

    The purpose of this study is to calculate the minimal clinically important difference (MCID), substantial clinical benefit (SCB), and...

    Matthew G. Alben, Neil Gambhir, ... Mandeep S. Virk in Clinical Rheumatology
    Article 22 December 2022
  16. Values derived from patient reported outcomes in spine surgery: a systematic review of the minimal clinically important difference, substantial clinical benefit, and patient acceptable symptom state

    Purpose

    While patient reported outcome measures (PROMs) define value in spine surgery, several values such as minimal clinically important difference...

    Tariq Z. Issa, Yunsoo Lee, ... Christopher K. Kepler in European Spine Journal
    Article 29 August 2023
  17. Common misunderstandings of evidence-based medicine

    Currently, most evidence assessments in guidelines or health technology assessments (HTAs) rely on the assumption that a randomized controlled trial...

    Frank Semrau, Pamela Aidelsburger, Carsten Walter Israel in Herzschrittmachertherapie + Elektrophysiologie
    Article Open access 07 August 2023
  18. Living evidence and adaptive policy: perfect partners?

    Background

    While there has been widespread global acceptance of the importance of evidence-informed policy, many opportunities to inform health policy...

    Tari Turner, John N. Lavis, ... Julian Elliott in Health Research Policy and Systems
    Article Open access 18 December 2023
  19. The Evidence for Implantable Sacral Neuromodulation in Pediatric Voiding Dysfunction

    Purpose of Review

    The purpose of this review is to evaluate the evidence regarding the efficacy and safety of implantable sacral neuromodulation (SNM)...

    Mariam Malallah, Anne Cameron, Bryan Sack in Current Bladder Dysfunction Reports
    Article Open access 27 June 2024
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