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Albuminuria and Serum Tumor Necrosis Factor Receptor Levels in Patients with Type 2 Diabetes on SGLT2 Inhibitors: A Prospective Study
IntroductionLarge-scale clinical trials of sodium-glucose cotransporter 2 inhibitors (SGLT2i) demonstrate proteinuria-reducing effects in diabetic...
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Tumor necrosis factor-alpha blockade suppresses BK polyomavirus replication
PurposeBK Polyomavirus (BKPyV) infection manifests as renal inflammation and can cause kidney damage. Tumor necrosis factor-α (TNF-α) is increased in...
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Systemic inflammation and delirium during critical illness
PurposeThe purpose of this study was to determine associations between markers of inflammation and endogenous anticoagulant activity with delirium...
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Th1 cytokines in pediatric acute lymphoblastic leukemia
Immune milieus play an important role in various types of cancer. The present study focuses on the effect of Th1 cytokines on pediatric acute...
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Tumor biomarkers for diagnosis, prognosis and targeted therapy
Tumor biomarkers, the substances which are produced by tumors or the body’s responses to tumors during tumorigenesis and progression, have been...
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Etanercept-associated episcleritis: a pediatric case report of a paradoxical adverse reaction and review of the literature
Scleritis is an inflammation of the episcleral and scleral tissues, characterized by injection in both superficial and deep episcleral vessels. When...
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Serum progranulin/tumor necrosis factor-α ratio as independent predictor of systolic blood pressure in overweight hypertensive patients: a cross-sectional study
BackgroundVascular inflammation plays a key role in the progression of hypertension. Progranulin (PGRN), an anti-inflammatory growth factor, mediated...
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Advancing Biologic Therapy for Refractory Autoimmune Hepatitis
Biologic agents may satisfy an unmet clinical need for treatment of refractory autoimmune hepatitis. The goals of this review are to present the...
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Advances in tumor microenvironment and underlying molecular mechanisms of bladder cancer: a systematic review
Bladder cancer is one of the most frequent malignant tumors of the urinary system. The prevalence of bladder cancer among men and women is roughly...
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A review article of inflammatory bowel disease treatment and pharmacogenomics
Inflammatory bowel disease (IBD) involves a variety of conditions, particularly Crohn’s disease (CD) and ulcerative colitis (UC). IBD is...
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Etanercept as a TNF-alpha inhibitor depresses experimental retinal neovascularization
PurposeThe formation of retinal neovascularization (RNV) is the primary pathological process underlying retinopathy of prematurity (ROP). Previous...
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Effects of bovine tumor necrosis factor alpha decoy receptors on cell death and inflammatory cytokine kinetics: potential for bovine inflammation therapy
BackgroundRefractory diseases, including bacterial infections, are causing huge economic losses in dairy farming. Despite efforts to prevent and...
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Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair
Maxillofacial bone defects are commonly seen in clinical practice. A clearer understanding of the regulatory network directing maxillofacial bone...
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The second decade of anti-TNF-a therapy in clinical practice: new lessons and future directions in the COVID-19 era
Since the late 1990s, tumor necrosis factor alpha (TNF-α) inhibitors (anti-TNFs) have revolutionized the therapy of immune-mediated inflammatory...
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A Review of the Totality of Evidence for the Development and Approval of ABP 710 (AVSOLA), an Infliximab Biosimilar
ABP 710 (AVSOLA ® ) is a biosimilar to infliximab reference product (RP), a monoclonal antibody targeting tumor necrosis factor alpha (TNFα). It is...
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New Biomarkers in Anaphylaxis (Beyond Tryptase)
Purpose of ReviewThe purpose of this review is to provide a better understanding of anaphylaxis pathophysiology and describe the underlying...
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Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study
BackgroundSoluble tumor necrosis factor receptor (sTNFR)1, sTNFR2, and plasma kidney injury molecule-1 (KIM-1) are associated with kidney events in...
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The TWEAK/Fn14/CD163 axis—implications for metabolic disease
TWEAK (tumor necrosis factor-like weak inducer of apoptosis) is a member of the TNF superfamily that controls a multitude of cellular events...
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Cancer-triggered systemic disease and therapeutic targets
Cancer provokes systemic diseases through three possible mechanisms: 1) Distal metastasis in multiple tissues and organs, which directly causes...
