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Sodium butyrate attenuates aortic lipotoxicity and impaired nitric oxide synthesis in female Wistar rats exposed to high-fructose drink
High fructose (HFr) intake results in dyslipidemia with consequent insulin resistance through metabolic derangements. Inadequate mobilization of...
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Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation
Ketone bodies have beneficial metabolic activities, and the induction of plasma ketone bodies is a health promotion strategy. Dietary supplementation...
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Chronic radiation proctitis refractory to steroid enema was successfully treated by metformin and sodium butyrate: a case report
BackgroundRadiation proctitis (RP) is a significant complication of pelvic radiation. Effective treatments for chronic RP are currently lacking. We...
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Sodium Acetate and Sodium Butyrate Differentially Upregulate Antimicrobial Component Production in Mammary Glands of Lactating Goats
Short-chain fatty acids activate antimicrobial component production in the intestine. However, their effects on mammary glands remain unclear. We...
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Butyrate and tributyrin reduce LPS-induced inflammatory cytokine production from human visceral fat
IntroductionThe current obesity crisis has resulted in many people with excess adipose tissue suffering from chronic inflammation. This inflammation...
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Exploring the combined anti-cancer effects of sodium butyrate and celastrol in glioblastoma cell lines: a novel therapeutic approach
Glioblastoma, a highly aggressive and lethal brain cancer, lacks effective treatment options and has a poor prognosis. In our study, we explored the...
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Mechanism of sodium butyrate, a metabolite of gut microbiota, regulating cardiac fibroblast transdifferentiation via the NLRP3/Caspase-1 pyroptosis pathway
BackgroundCardiac fibroblasts (CFs) are activated after initial injury, and then differentiate into myofibroblasts (MFs), which play a pivotal role...
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Sodium Butyrate Inhibits Oxidative Stress and NF-κB/NLRP3 Activation in Dextran Sulfate Sodium Salt-Induced Colitis in Mice with Involvement of the Nrf2 Signaling Pathway and Mitophagy
BackgroundSodium butyrate (NaB) is a short-chain fatty acid produced by intestinal microbial fermentation of dietary fiber, and has been shown to be...
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Bacterial metabolite butyrate in modulating sorafenib-targeted microRNAs to curtail its resistance in hepatocellular carcinoma
Background and AimThe host dietary fibre is fermented into short-chain fatty acids (SCFA) by intestinal microbiota as bacterial metabolites like...
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Butyrate driven raft disruption trots off enteric pathogen invasion: possible mechanism of colonization resistance
The gut microbiome derived short chain fatty acids perform multitude of functions to maintain gut homeostasis. Here we studied how butyrate stymie...
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Butyrate induces development-dependent necrotizing enterocolitis-like intestinal epithelial injury via necroptosis
BackgroundThe accumulation of short-chain fatty acids (SCFAs) from bacterial fermentation may adversely affect the under-developed gut as observed in...
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Hepatic dysmetabolism in polycystic ovarian syndrome: impact of paraoxonase-1 modulation by butyrate
The complications of endocrine-metabolic disorders among women of reproductive age, inclusively polycystic ovarian syndrome (PCOS), are cascade of...
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Sodium butyrate enhances titanium nail osseointegration in ovariectomized rats by inhibiting the PKCα/NOX4/ROS/NF-κB pathways
BackgroundElevated levels of oxidative stress as a consequence of estrogen deficiency serve as a key driver of the onset of osteoporosis (OP). In...
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Cardiac angiogenesis enhances by activating Mir-126 and related target proteins in type 2 diabetic rats: Rescue combination effect of Sodium butyrate and voluntary exercise therapy
Objectivetype 2 diabetes, metabolic disorder, is one of the main risk factors for cardiovascular disease, leading to angiogenesis injury. The present...
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Butyrate: More Than a Short Chain Fatty Acid
Purpose of ReviewThe mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in...
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The effects of sodium butyrate supplementation on the expression levels of PGC-1α, PPARα, and UCP-1 genes, serum level of GLP-1, metabolic parameters, and anthropometric indices in obese individuals on weight loss diet: a study protocol for a triple-blind, randomized, placebo-controlled clinical trial
BackgroundObesity is a multifaceted disease characterized by an abnormal accumulation of adipose tissue. Growing evidence has proposed...
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Butyrate alleviates adipose mitochondrial dysfunction and inflammation in experimental model of polycystic ovarian syndrome by modulating SIRT1-dependent mechanism
PurposeImpaired adipose tissue (AT) remodeling has been suggested as a pathophysiological driver of endocrinometabolic events in polycystic ovarian...
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Butyrate inhibits the mitochondrial complex Ι to mediate mitochondria-dependent apoptosis of cervical cancer cells
BackgroundCervical cancer (CC) is a common gynecological malignancy with high morbidity worldwide. Butyrate, a short-chain fatty acid produced by...
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A study of impurity profiling via method development and force degradation in hydrocortisone butyrate at low concentration
BackgroundSince long, triamcinolone and fluocinolone, fluorinated derivatives, have been used for treating various types of dermatitis. Rosacea and...
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Impact of buffered sodium butyrate as a partial or total dietary alternative to lincomycin on performance, IGF-1 and TLR4 genes expression, serum indices, intestinal histomorphometry, Clostridia, and litter hygiene of broiler chickens
BackgroundSodium butyrate (SB) is a short-chain fatty acid and a safe antibiotic alternative. During 35 days, this study compared the impact of...
