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Advancing skeletal health and disease research with single-cell RNA sequencing
Orthopedic conditions have emerged as global health concerns, impacting approximately 1.7 billion individuals worldwide. However, the limited...
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Exploring the advances of single-cell RNA sequencing in thyroid cancer: a narrative review
Thyroid cancer, a prevalent form of endocrine malignancy, has witnessed a substantial increase in occurrence in recent decades. To gain a...
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Advances in single-cell RNA sequencing and its applications in cancer research
Cancers are a group of heterogeneous diseases characterized by the acquisition of functional capabilities during the transition from a normal to a...
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Single-cell RNA sequencing in orthopedic research
Although previous RNA sequencing methods have been widely used in orthopedic research and have provided ideas for therapeutic strategies, the...
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Single-cell RNA sequencing and kidney organoid differentiation
Since 2015, Japanese researchers have made great progress in develo** a method to differentiate human pluripotent stem cells (hPSCs) into kidney...
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Nephroblastoma-specific dysregulated gene SNHG15 with prognostic significance: scRNA-Seq with bulk RNA-Seq data and experimental validation
Wilms tumor (WT) is the most common malignancy of the genitourinary system in children. Currently, the Integration of single-cell RNA sequencing...
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Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions
Chronic rhinosinusitis (CRS) is a heterogenic disease characterized by persistent mucosal inflammation of the upper airway. Researches of CRS have...
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Single-cell and bulk RNA sequencing reveal heterogeneity and diagnostic markers in papillary thyroid carcinoma lymph-node metastasis
PurposePapillary thyroid carcinoma (PTC) is characterized by lymph-node metastasis (LNM), which affects recurrence and prognosis. This study analyzed...
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Clustering single-cell RNA sequencing data via iterative smoothing and self-supervised discriminative embedding
Single-cell transcriptome sequencing (scRNA-seq) is a high-throughput technique used to study gene expression at the single-cell level. Clustering...
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Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside
The mechanisms of cardiovascular diseases (CVDs) remain incompletely elucidated. Single-cell RNA sequencing (scRNA-seq) has enabled the profiling of...
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Prognostic model based on B cell marker genes for NSCLC patients under neoadjuvant immunotherapy by integrated analysis of single-cell and bulk RNA-sequencing data
BackgroundNeoadjuvant immunotherapy has evolved as an effective option to treat non-small cell lung cancer (NSCLC). B cells play essential roles in...
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The molecular landscape of neurological disorders: insights from single-cell RNA sequencing in neurology and neurosurgery
Single-cell ribonucleic acid sequencing (scRNA-seq) has emerged as a transformative technology in neurological and neurosurgical research,...
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Single-cell RNA sequencing of anaplastic ependymoma and H3K27M-mutant diffuse midline glioma
BackgroundAnaplastic ependymoma and H3K27M-mutant diffuse midline glioma are two common subtypes of brain tumors with poor long-term prognosis. The...
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Unraveling intratumoral complexity in metastatic dermatofibrosarcoma protuberans through single-cell RNA sequencing analysis
Dermatofibrosarcoma protuberans (DFSP) stands as a rare and locally aggressive soft tissue tumor, characterized by intricated molecular alterations....
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Single-cell RNA sequencing of intestinal immune cells in neonatal necrotizing enterocolitis
PurposeNecrotizing enterocolitis (NEC) causes fatal intestinal necrosis in neonates, but its etiology is unknown. We analyzed the intestinal immune...
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New genetic insights into immunotherapy outcomes in gastric cancer via single-cell RNA sequencing and random forest model
ObjectiveThe high mortality rate of gastric cancer, traditionally managed through surgery, underscores the urgent need for advanced therapeutic...
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The heterogeneity of breast cancer metastasis: a bioinformatics analysis utilizing single-cell RNA sequencing data
PurposeBreast cancer is a common malignancy in women, and its metastasis is a leading cause of cancer-related deaths. Single-cell RNA sequencing...
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Identification of potential diagnostic biomarkers for tenosynovial giant cell tumour by integrating microarray and single-cell RNA sequencing data
PurposeTenosynovial giant cell tumour (TGCT) is a benign hyperplastic and inflammatory disease of the joint synovium or tendon sheaths, which may be...
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CaSee: A lightning transfer-learning model directly used to discriminate cancer/normal cells from scRNA-seq
Single-cell RNA sequencing (scRNA-seq) is one of the most efficient technologies for human tumor research. However, data analysis is still faced with...
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Recent developments in application of single-cell RNA sequencing in the tumour immune microenvironment and cancer therapy
The advent of single-cell RNA sequencing (scRNA-seq) has provided insight into the tumour immune microenvironment (TIME). This review focuses on the...
